Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although animal models of infection are associated with certain limitations in interpretation, properly performed studies provide important information for evaluating the efficacy of new antimicrobial agents in the treatment of human disease. The antibacterial efficacy of the newer quinolones, particularly ciprofloxacin, has undergone extensive evaluation in several animal models. Efficacy has been demonstrated in animal models of pneumonia, endocarditis, meningitis, skin and soft-tissue infections, septic arthritis, burn wound sepsis, empyema, intra-abdominal abscess, osteomyelitis, prostatitis, sinusitis, urinary tract infection, chronic gastroenteritis, granuloma pouch infection, and Pseudomonas septicemia. More recent studies have evaluated the efficacy of ciprofloxacin in animal models of tuberculosis and syphilis, as well as in infections caused by the intracellular pathogens Salmonella typhimurium, Legionella pneumophila, and Listeria monocytogenes.
 ...
PMID:An update on the efficacy of ciprofloxacin in animal models of infection. 258 79

A 23-year-old woman gravely ill with Pseudomonas septicemia secondary to presumed drug-induced bone marrow aplasia received marrow transplantation from two male HL-A identical sibling donors. She had a successful engraftment with excellent but temporary clinical improvement. Subsequently she succumbed to graft-versus-host disease manifested by Pseudomonas and Candida albicans septicemia, cytomegalovirus pneumonitis, three phases of dermatitis, nausea, vomiting, dysphagia, diarrhea, fever, edema and bone pain, with gradual but complete graft suppression by the 74th day after the transplantation. A second marrow transplant on the 70th day was unsuccessful.
 ...
PMID:Bone marrow transplantation in a patient with drug-induced aplastic anemia. 440 93

Septicaemia due to Pseudomonas pseudomallei was found in five patients; it complicated pneumonia in three. Four patients were old and had diabetes mellitus; the fifth patient, though young, was immunocompromised by steroid therapy. The clinical features were indistinguishable from those of other Gram-negative septicaemia. Four of the patients died. This was the first report of septicaemic melioidosis in Hong Kong where the disease might be endemic. Soil sampling and serological survey gave further supporting evidence. Early treatment using a bactericidal anti-Pseudomonal cephalosporin, such as ceftazidime, was suggested for this life-threatening infection.
 ...
PMID:First report of septicaemic melioidosis in Hong Kong. 648 53

A review is given of the role of the various host defences in man against Pseudomonas aeruginosa and the mechanisms by which these are compromised in certain patient categories especially susceptible to serious Pseudomonas infections. The defects of host defences are usually complex and multiple, affecting various sites in the local and the systemic defences. Certain defects are emphasized, e.g. abnormalities of first line defences (skin, mucous membranes), and both quantitative and qualitative defects in polymorphonuclear granulocytes. However, it is also suggested that compromised functions of other components of antimicrobial defences may play a role in Pseudomonas infections, e.g. functional abnormalities in the systems of B cells. T cells and mononuclear phagocytes. Recent data suggesting mechanisms by which P. aeruginosa can exert suppressive effects on host defences, are mentioned, and the possibility of immunopathogenesis in Pseudomonas infections is discussed, particularly processes involving the complement system. Some important clinical features of Pseudomonas infections are described. The clinical peculiarities of bacterial infections in the severely neutropenic patient are emphasized, and exemplified with a brief description of Pseudomonas pneumonia. Finally, Pseudomonas septicaemia is mentioned with a brief discussion of certain important prognostic factors. It is concluded that a better understanding of the complex defense mechanisms against P. aeruginosa and therapeutic regimens by which they can be manipulated, is imperative to achieve any significant advances in the prevention and treatment of these infections.
 ...
PMID:Infections with Pseudomonas aeruginosa in the compromised host. 679 60

A 29-yr-old male developed Cushing's syndrome with severe hypokalaemia, alkalosis and hypernatraemia. He died with Pseudomonas septicaemia and Nocardia pneumonia. At autopsy he was found to have a carcinoid tumour of the thymus which was not suspected before death, and marked bilateral hyperplasia of the adrenal cortex.
 ...
PMID:Carcinoid tumour of the thymus with Cushing's syndrome. 743 24