Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The staining of viral antigens present in formalin-fixed, paraffin-embedded tissues by fluorescent antibodies is markedly enhanced by trypsin digestion. When the trypsin digestion method was used to detect viral antigens present in hamster brain following experimental infection with measles virus, the results were comparable to those obtained with acetone-fixed, freshly frozen tissues that had been sectioned with a cryostat. Measles antigens were readily identified in brain cells from a patient with subacute sclerosing panencephalitis and in lung and liver tissue from a patient with acute giant cell pneumonia, following preparation of the tissues for routine histologic examination. Viral antigens were detected in brain tissue that had been taken from patients with herpes simplex encephalitis and stored in paraffin for up to 15 years. Cells containing antigen could be precisely identified without loss of histologic detail by restaining the same tissue sections with hematoxylin and eosin.
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PMID:Enhancement of fluorescent antibody staining of viral antigens in formalin-fixed tissues by trypsin digestion. 23 Oct 70

The authors reviewed all measles cases admitted to the pediatric ward of Goroka Base Hospital in 1989, and also interviewed a sample of measles patients attending the pediatric outpatient department. Measles accounted for 11% of all pediatric admissions and 32% of deaths. The case fatality rate for measles was 17%. Children with nosocomial infections and those of low birthweight were more likely to die. The most common complications of measles were pneumonia and diarrhea, pneumonia being the most common cause of death. 12 cases of subacute sclerosing panencephalitis were admitted during the year (0.5% of pediatric admissions). Measles was underreported because it was frequently omitted from the discharge diagnosis, the emphasis being placed on complications. The majority of children with measles admitted to the ward and seen as outpatients had not been vaccinated. Nosocomial infections could have been reduced if all pediatric admissions ages 6-35 months had been vaccinated on admission. The authors strongly endorse the policy of vaccinating children in Papua New Guinea against measles from the age of 6 months.
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PMID:A review of measles admissions and deaths in the paediatric ward of Goroka Base Hospital during 1989. 205 4

The role of measles virus in persistent infections has been reviewed. Measles, normally a benign disease of children can give rise directly to complications (encephalitis, pneumonia) or after a period of months or years lead to a slow neurological infection (subacute sclerosing panencephalitis). The models, both "in vitro" and "in vivo", which have been developed to study the factors involved in measles virus persistence, are compared and related to the parameters observed in the human disease. The evidence that measles virus is associated with other long term diseases (multiple sclerosis, Paget'b bone disease) is discussed.
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PMID:Measles virus and chronic infections. 702 50

In the summer of 1990 an epizootic infection caused by a morbillivirus (DMV) killed several thousand striped dolphins (Stenella coeruleoalba) in the Mediterranean Sea. In 1991 and 1992 the epizootic reached Italian and Greek waters. The infection by DMV in the acute period of the epizootic caused encephalitis, pneumonia and depletion of lymph nodes. After 1990, the systemic infection apparently disappeared from the Catalonian coast, giving way to cases of chronic infection of the CNS. Dolphins that died between 1991 and May 1994 were necropsied, and investigated for lesions due to DMV, and for the presence of morbillivirus antigen in tissues. Encephalitis occurred in 6 dolphins in which DMV antigen was demonstrated in the CNS and which were without lesions or antigen in other, non-nervous tissues. Inflammatory lesions, gliosis, and DMV antigen decreased in density and amount from cerebral grey matter, through the thalamic areas to the medulla oblongata. The cerebellum was usually spared. Lesions consisted of non-suppurative encephalitis, with diffuse gliosis and glial nodules and neuronophagia, and loss of neurons. Perivascular cuffing of lymphocytes and plasma cells was present in the cerebral cortex and the white matter beneath the cortex. Multinucleate syncytia were not detected in any of the dolphins. The haemagglutinin of DMV was detected mainly in neurons in the cerebral cortical areas. There was no clear relationship between the presence and amount of DMV antigen and the density or chronicity of lesions. Viral inclusions were seen in haematoxylin and eosin stained sections in 3/6 dolphins, principally in the nucleus and the cytoplasm of neurons. In the immunoperoxidase stained sections, dense granular deposits of chromogen, similar to viral inclusions, were evident in all 6 dolphins. The change in the distribution of lesions and of DMV antigen, from systemic to localized in the CNS, and the clustering of systemic DMV infections in the first four months of the epizootic, giving rise to sporadic occurrence of local CNS infection in the subsequent four years, as well as the chronic nature of the CNS lesions, which closely resembles subacute sclerosing panencephalitis, strongly support the existence of a chronic morbillivirus infection in the striped dolphin, as a delayed consequence of the 1990 epizootic.
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PMID:Evidence for chronic morbillivirus infection in the Mediterranean striped dolphin (Stenella coeruleoalba). 858 17

The implied aetiological association of measles virus with Crohn's disease would be supported by detection of an immune response to infected cells in affected tissues. This study sought to detect and characterise in situ immune responses to measles virus in both acutely and persistently infected tissues, and in particular, Crohn's granulomata. Tissue sections from patients with Crohn's disease (n = 17), tuberculosis (n = 9), acute intestinal ischaemia (n = 5), acute measles pneumonitis (n = 2), acute measles appendicitis (n = 1), subacute sclerosing panencephalitis (SSPE; n = 1), and measles inclusion body encephalitis (MIBE; n = 1), were examined. Single and double immunohistochemical labelling was performed to identify both cytotoxic lymphocytes (CD8, TIA, perforin, Leu 7, CD45RO, CD45RA) and macrophages (KP1). The relationship of these cells to measles infected cells was examined by double immunolabelling with antimeasles virus nucleoprotein antibody. In both acute measles appendicitis and SSPE, CD8+/TIA cytotoxic lymphocytes (CTL) targeted infected cells. In the cases of Crohn's disease (13/17), MIBE, fatal pneumonitis, and one tuberculous granuloma, that were positive for measles virus, infected cells appeared to be targeted by macrophages rather than CTL. CTL in both tuberculous and Crohn's granulomata were similar in their peripheral distribution, number, and phenotype. The data suggest that measles-specific CTL responses may be attenuated in Crohn's disease compared with acute measles appendicitis and SSPE, and secondly, that an abnormal macrophage response to persistent measles virus infection of the intestine may result in granulomatous inflammation.
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PMID:In situ immune responses in Crohn's disease: a comparison with acute and persistent measles virus infection. 902 38

In an autopsy study the distribution of measles virus (MV) in the central nervous system (CNS) of 18 measles-infected children (13 HIV seropositive, 5 HIV seronegative), in Abidjan, Ivory Coast was examined using immunocytochemistry and in situ hybridization. Of these children 17 died from measles giant cell pneumonia. In 3 of the 13 HIV-seropositive patients MV antigens and genomic RNA was detected in the CNS. One of these positive patients had an MV encephalitis with abundant virus throughout most of the CNS. MV was not detected in the CNS of any of the 5 HIV-seronegative patients. These findings, albeit in a small number of cases, would suggest there may be an increased susceptibility to infection of the CNS with MV in HIV-positive children. In this respect entry and growth of MV in the CNS in HIV-seropositive individuals may be similar to the occurrence of measles inclusion body encephalitis in immunocompromised individuals. Furthermore, comparison of the HIV-MV encephalitis patient with two patients with subacute sclerosing panencephalitis (SSPE) demonstrated a paucity of virus in neuronal processes in the HIV-MV encephalitis. Unlike in SSPE, MV maturation by budding through the plasma membrane may occur, thereby minimizing build up of and intracellular movement of incomplete virus.
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PMID:Distribution of measles virus in the central nervous system of HIV-seropositive children. 984 94

Measles is a highly contagious disease characterized by a prodromal illness of fever, coryza, cough, and conjunctivitis followed by the appearance of a generalized maculopapular rash. Despite the availability of an effective and safe live attenuated vaccine, measles remains a cause of continuing outbreaks in Japan. Measles often accompanies diverse complications, including pneumonitis, otitis media, and central nervous system involvement. Neurological complications of measles includes ADEM, MIBE, and SSPE. MIBE and SSPE have unfavorable prognosis, which are caused by persistent infection of particular mutants of measles virus (MV) in brain. In SSPE patients, measles antibody titer increase in cerebrospinal fluid and serum. Primary vaccine failure and secondary vaccine failure may be a major cause of outbreaks in Japan, therefore, promotion of vaccination should be emphasized. 2 doses vaccination methods began in Japan in 2006, and supplementary vaccination program at 12 and 18 years old begins from 2008. Protection level of antibody titer varies according to the antibody measurement methods. NT provides the best correlate for protection from infection, however, needs complicated procedure. PA is chosen for the surveillance method in Japan, and 1:128 or over seems protection level. To protect health-care associated infection of MV, all health care worker under 35 years old should be vaccinated if not have adequate immunity.
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PMID:[Pathophysiology and laboratory findings in measles]. 1831 31

Measles is a highly contagious human disease caused by measles virus (MeV) and remains the leading cause of death in children, particularly in developing countries. Wild-type MeV preferentially infects lymphocytes by using signaling lymphocytic activation molecule (SLAM), whose expression is restricted to hematopoietic cells, as a receptor. MeV also infects other epithelial and neuronal cells that do not express SLAM and causes pneumonia and diarrhea and, sometimes, serious symptoms such as measles encephalitis and subacute sclerosing panencephalitis. The discrepancy between the tissue tropism of MeV and the distribution of SLAM-positive cells suggests that there are unknown receptors other than SLAM for MeV. Here we identified CD147/EMMPRIN (extracellular matrix metalloproteinase inducer), a transmembrane glycoprotein, which acts as a receptor for MeV on epithelial cells. Furthermore, we found the incorporation of cyclophilin B (CypB), a cellular ligand for CD147, in MeV virions, and showed that inhibition of CypB incorporation significantly attenuated SLAM-independent infection on epithelial cells, while it had no effect on SLAM-dependent infection. To date, MeV infection was considered to be triggered by binding of its hemagglutinin (H) protein and cellular receptors. Our present study, however, indicates that MeV infection also occurs via CD147 and virion-associated CypB, independently of MeV H. Since CD147 is expressed in a variety of cells, including epithelial and neuronal cells, this molecule possibly functions as an entry receptor for MeV in SLAM-negative cells. This is the first report among members of the Mononegavirales that CD147 is used as a virus entry receptor via incorporated CypB in the virions.
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PMID:CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells. 2014 91

Measles is an infectious disease in humans caused by the measles virus (MeV). Before the introduction of an effective measles vaccine, virtually everyone experienced measles during childhood. Symptoms of measles include fever and maculopapular skin rash accompanied by cough, coryza and/or conjunctivitis. MeV causes immunosuppression, and severe sequelae of measles include pneumonia, gastroenteritis, blindness, measles inclusion body encephalitis and subacute sclerosing panencephalitis. Case confirmation depends on clinical presentation and results of laboratory tests, including the detection of anti-MeV IgM antibodies and/or viral RNA. All current measles vaccines contain a live attenuated strain of MeV, and great progress has been made to increase global vaccination coverage to drive down the incidence of measles. However, endemic transmission continues in many parts of the world. Measles remains a considerable cause of childhood mortality worldwide, with estimates that >100,000 fatal cases occur each year. Case fatality ratio estimates vary from <0.01% in industrialized countries to >5% in developing countries. All six WHO regions have set goals to eliminate endemic transmission of MeV by achieving and maintaining high levels of vaccination coverage accompanied by a sensitive surveillance system. Because of the availability of a highly effective and relatively inexpensive vaccine, the monotypic nature of the virus and the lack of an animal reservoir, measles is considered a candidate for eradication.
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PMID:Measles. 2741 84

Clearance of measles virus is complex. Infectious virus is cleared by the adaptive immune response manifested by the characteristic maculopapular rash. CD8+ T cells are major effectors of infectious virus clearance, a process that may fail in individuals with compromised cellular immune responses leading to progressive giant cell pneumonia and/or measles inclusion body encephalitis. In contrast to the usual rapid clearance of infectious virus, clearance of viral RNA is slow with persistence in lymphoid tissue for many months. Persistence of MeV RNA may contribute to the late development of the slowly progressive disease subacute sclerosing panencephalitis in children infected at a young age and to measles-associated immune suppression but also to maturation of the immune response and development of life-long immunity.
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PMID:Measles virus persistence and its consequences. 3238 98


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