Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Simultaneous occurrence of cold agglutinin hemolytic anemia and central nervous system disease due to Mycoplasma pneumonia is extremely rare. A patient is described who initially presented with severe hemolysis and diffuse neurologic dysfunction which appeared during the period of roentgenographic resolution of her pneumonia. Spectrum, pathogenesis, and antimicrobial treatment of the neurologic complications are reviewed.
 ...
PMID:Mycoplasma pneumonia presenting as meningoencephalitis and hemolytic anemia. 9 44

The epidemic occurrence of mycoplasmal pneumonia in children was reported. It composed 8% of all cases of pneumonia during 1975 occurring in the area served by the University Pediatric Hospital in Giessen. It should be noted that the cases were distributed throughout the year and that one fourth of the patients were small children. The diversity of the radiologic appearance with primarily interstitial-alveolar lesions in the lungs was explained in more detail. Observations of the course of the disease indicate that the illness can be recurrent; the course can be complicated as a result of immunosuppression through a primary illness which is already present, in this case an acute lymphoblastic leukemia.
 ...
PMID:[Increased occurrence of mycoplasmal pneumonia: radiologic appearance and observation of the development of the disease in children (author's transl)]. 26 71

Clindamycin-2-phosphate (7(S)-chloro-7-deoxylincomycin-2-phosphate) is a new semi-synthetic antibiotic. It is recognized that the drug itself is inactive against bacteria in vitro but it is hydrolyzed rapidly to active clindamycin, drug intramuscular or intravenous administration. Clindamycin-2-phosphate was administrated intravenously to seven patients with infections, except one intramuscularly, 300 approximately 600 mg, every 8 or 12 hours a day, for 2 approximately 12 days. Three patients (1 bacterial pneumonia, 1 chronic bronchitis and 1 urinary tract infection due to E. coli) recovered from their infection; one patient (bacterial infection in bronchiectasis) partially responded; and three patients (1 urinary tract infection due to E. coli, 1 pneumonia due to Mycoplasma pneumoniae and 1 patient with mycoplasmal pneumonia and acute biliary tract infection) failed to respond to the drug. No remarkable side effect was noted except pain at intramuscular injection site in one patient.
 ...
PMID:[Clinical evaluation of clindamycin-2-phosphate in infectious diseases (author's transl)]. 32 Mar 61

We describe a patient with sickle cell hemoglobin C(SC) disease in whom severe pneumonia developed complicated by large bilateral pleural effusions and respiratory failure. Mycoplasma infection was not initially suspected but was subsequently proved serologically. The course of the illness was unusually long. A review of the literature showed occurrence of large pleural effusions to be infrequent for pulmonary infection with Mycoplasma in adults, with only eight such cases previously reported. The possibility of Mycoplasma pneumonia should not be dismissed merely because of the severity of the illness or the presence of pleural effusions.
 ...
PMID:Severe mycoplasma pneumonia with pleural effusions in a patient with sickle cell-hemoglobin C(SC) disease. Case report and review of the literature. 43 75

Pneumonia due to Mycoplasma pneumoniae was monitored in a large prepaid medical-care group in Seattle, Washington, between 1963 and 1975. The disease was diagnosed by isolation of M. pneumoniae and/or significant rises in titer of complement-fixing (antilipid) antibody in paired sera. Infection was endemic without significant seasonal fluctuations. Two epidemics occurred: the first peaked in January 1967, the second late in the summer of 1974. Total rates of pneumonia infection in children increased during M. pneumoniae epidemics, but epidemics of infection with respiratory syncytial virus had a greater effect. Age-specific attack rates for M. pneumoniae pneumonia among children aged five to nine years (about six per 1,000) were about twice the rates for younger children and four times those for adults. Serologic study of healthy schoolchildren showed annual rates of infection that paralleled but greatly exceeded rates of recognized M. pneumoniae pneumonia. Infection rates varied from 2% in endemic years to 35% in epidemic periods. A higher proportion of infections among children aged five to nine years than among adolescents aged 15-19 years resulted in pneumonia.
 ...
PMID:Long-term epidemiology of infections with Mycoplasma pneumoniae. 44 95

Mycoplasmal pneumonia, tularemic pneumonia, Q fever pneumonia, psittacosis, and Legionnaires' disease are the most frequently encountered treatable atypical pneumonias. Mycoplasmal pneumonia, the most common, is often accompanied by nonexudative pharyngitis, conjunctivitis, or otitis. The nonproductive cough is characteristic. Tularemic pneumonia is characterized by substernal chest pain, bloody pleural effusion, and bilateral hilar adenopathy. Although the clinical presentation is mild, roentgenographic findings are impressive. Q fever pneumonia resembles psittacosis but is less serious; it may be accompanied by subacute bacterial endocarditis, hepatitis, or both. Psittacosis is characterized by prominent headache, bloody sputum, and relative bradycardia. Tetracycline is the drug of choice for either. In Legionnaires' disease, pneumonia is accompanied by prominent extrapulmonary symptoms. The most important diagnostic clues include diarrhea and mental confusion. Relative bradycardia and laboratory abnormalities are also helpful. Erythromycin is the drug of choice unless doubt exists as to the diagnosis.
 ...
PMID:The atypical pneumonias: a diagnostic and therapeutic approach. 47 55

A total of 53 clinical specimens from both healthy and diseased Rocky Mountain bighorn sheep (Ovis canadensis) were examined for Chlamydia. An agent consistently lethal for chicken embryos was recovered from a nasal swab taken from a normal ewe. This agent, designated BHS-15, possesses antigens which fix complement in the presence of anti-chlamydial serum, is susceptible to chlortetracycline, and is resistant to sodium sulfadiazine and streptomycin. Attempts to culture the isolate in quality control media, including blood agar, thioglycolate broth, and PPLO broth and agar were unsuccessful. A recommendation is made for classification of agent BHS-15 as a member of the species Chlamydia psittaci. The possible relationship of the isolate to the pneumonia complex in bighorn sheep is discussed.
 ...
PMID:Isolation of a chlamydial agent from Rocky Mountain bighorn sheep. 52 18

Tracheobronchial clearance was studied in 17 non-smokers who had suffered from a serologically verified Mycoplasma pneumoniae pneumonia 5-15 months earlier. The subjects inhaled 6 micron teflon particles tagged with 99mTc. The retention of the particles in the lungs was measured for 2 h. The retention after 2 h in this group was significantly higher than in a control group of healthy non-smokers. The results suggest that some impairment persists 5-15 months after the infection or that persons with slow clearance contract a mycoplasma pneumonia more easily than do those with fast clearance.
 ...
PMID:Tracheobronchial clearance 5-15 months after infection with Mycoplasma pneumoniae. 63 74

A controlled, double-blind study was performed to compare the efficacy of two macrolide antibiotics, erythromycin and josamycin, in the therapy of Mycoplasma pneumoniae pneumonia. Marine Corps recruit volunteers received one of the two antibiotics in a dosage of 2 g daily for 7 days. Twelve of 21 men treated with josamycin and 9 of 25 men treated with erythromycin had confirmed M. pneumoniae pneumonia. The josamycin-treated group remained hospitalized for 5.4 +/- 1.2 days compared to 5.1 +/- 2.0 days for the erythromycin-treated group (0.60 > P > 0.50). Fever days were similar for the josamycin-treated (1.4 +/- 0.4) and erythromycin-treated (1.2 +/- 0.3) groups (P = 0.95). There was no difference in resolution of signs and symptoms of illness in the two study populations. Thus, josamycin is as efficacious as erythromycin in the therapy of M. pneumoniae pneumonia.
 ...
PMID:Comparison of josamycin and erythromycin in the therapy of Mycoplasma pneumoniae pneumonia. 79 75

Pneumonia in children tests the clinician's diagnostic and therapeutic acumen. Bacterial infection can occur at any age, while aspiration pneumonia is most common in the newborn, viral pneumonia is most prevalent in infants and preschoolers, and mycoplasmal pneumonia is most often encountered in school-aged children and young adults. Careful follow-up of outpatients will indicate whether the choice of therapy is adequate and should detect progressive disease requiring more specific diagnostic and therapeutic measures.
 ...
PMID:Pneumonia in children. 83 94


1 2 3 4 5 6 7 8 9 10 Next >>