Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 5 1/2 year old boy with I-cell disease (mucolipidosis II) had bilateral corneal haziness, early cortical cataracts and bilateral prominence of his eyes associated with shallow bony orbits. He died of pneumonia at age 5 1/2 years. Light and electron microscopic examination of the ocular and orbital tissues revealed an accumulation of acid mucopolysaccharide positive, hyaluronidase resistant material in fibroblasts and histiocytes which had partially replaced Bowman's membrane and the anterior stromal cells of the cornea. Similar material, as well as glycolipid-like substance, was found in the conjunctiva and in the retrobulbar soft tissues.
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PMID:Ocular involvement in I-cell disease (mucolipidosis II). Light and electron microscopic findings. 108 52

In June 1991, the Alaska Section of Vital Statistics reported that nine deaths of Alaskan Native infants occurred in seven villages in southwestern Alaska from January 1990 through June 1991. In comparison, seven Alaskan Native infant deaths occurred in these villages during 1986-1989. Two of the deaths during 1990-1991 had been attributed to acute viral myocarditis (International Classification of Diseases, Ninth Revision [ICD-9], code 422.9) and three to viral or unspecified pneumonitis (ICD-9 codes 480.9 and 486), while from 1985 through 1989, one infant death in these villages had been attributed to either of these causes. An examination of the clinical histories of these nine infants by the Alaska Division of Public Health (ADPH) suggested some of the diagnoses might be inaccurate. This report summarizes an investigation by the ADPH to assess the accuracy of the immediate cause of death recorded on the death certificates for the nine infants.
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PMID:Misclassification of infant deaths--Alaska, 1990-1991. 164 Sep 26

A case of I-cell disease is reported. The patient suffered from several episodes of pneumonia, and died of pneumonia at 12 months of age. Tissue specimens obtained at autopsy were stained with colloidal iron to demonstrate acid mucopolysaccharides. Characteristic foamy changes were observed in organs such as the heart, kidneys, liver, spleen and brain. An interesting finding in this case was that not only the interstitial cells but the alveolar epithelium in the lung showed the same foamy changes. The major causes of death of patients with I-cell disease are congestive heart failure and recurrent respiratory infections. However, there have been few reports on the histological changes in the lungs, and none have described the changes in the alveolar epithelium. Further cases must be investigated to examine the pathological relation between the histological changes in the lungs and the cause of death, because recurrent respiratory infections are the major contributor to death in patients with I-cell disease.
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PMID:A case of I-cell disease. 170 8

National hospital admission frequencies were analysed for asthma (ICD-9 code 493), acute bronchi(oli)tis (ICD-code 466), pneumonia and influenza (ICD-code 480-487), and chronic obstructive pulmonary disease (ICD-code 490-492 and 496) for 1980-1989 by sex and according to age (0-4 years, 5-9 years, and 10-14 years). Rates per million of the childhood population per year were calculated and time trend analyses performed by least squares regression. In the age group 0-4 years the admission rates for the respiratory diseases were highest and a general tendency towards increasing rates was present, and significant trends were found for asthma and acute bronchi(oli)tis. In the age groups 5-9 years and 10-14 years the admissions rates were considerably lower and fluctuated with no trends to point to except for a significant increasing trend for acute bronchitis in girls aged 5-9 years and a significant decreasing trend for asthma in boys aged 10-14 years. From the presented data it can be concluded that in childhood the health issue with respect to the respiratory diseases concerns the very young in particular.
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PMID:[Frequency of hospitalization for respiratory disorders in 0-14-year-old children]. 177 49

We grouped New Jersey residents according to age, sex, race, and residence-specific cumulative incidence of AIDS since the onset of the AIDS epidemic: less than 15, 15-99, 100-499, and greater than or equal to 500 cases per 100,000 people, respectively. We determined mortality from bacterial and viral pneumonias (International Classification of Diseases [ICD] 480.0-486.9) from underlying cause of death files. Between 1980 and 1986, pneumonia mortality increased from 15.1 deaths per 100,000 per year (95% confidence interval [CI] 10.4, 19.7) to 25.0 deaths per 100,000 per year (95% CI 19.2, 30.8), an increase of 10.0 deaths per 100,000 per year (95% CI 2.6, 17.3), among those 25-44 years of age in the highest cumulative incidence group for AIDS. Increases in other population subgroups were approximately proportional to each subgroup's AIDS cumulative incidence. In particular, pneumonia mortality did not increase among those 25-44 years of age in groups with low cumulative incidence of AIDS. Deficiency of cell-mediated immunity, a diagnosis commonly applied in AIDS cases, was listed as a secondary diagnosis in 14% of the pneumonia deaths of persons 25-44 years of age in 1986 and in none of those in 1980.
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PMID:Cumulative AIDS incidence and altered pneumonia mortality. 179 57

The discussion of communicable disease mortality highlights the problems of utilizing leading cause of death reporting, where the definition and characteristics of a short list influence the relative of all structural components, and thus the sequence of ranking. Leading cause structure is truncated and definitions and frequencies of nonleading causes are usually not made available. However, cause specific is all inclusive and can be easily visualized. Mortality analyses need to become more public health oriented and explanatory, to assist in the evaluation of the health status of the population, and be useful in delineating priorities and resource allocation. The importance of the issue is that developing countries appear to be similar to developed countries in their leading causes of death; communicable diseases are obscured as a leading cause. The broadness of the cause group gives a better chance of qualifying as a leading cause, i.e., diseases of the heart, cerebrovascular disease, malignant neoplasms, and accidents. Another problem is the use of a short list of causes when there has been a shift in the mortality pattern. When leading cause analysis is combined with infectious disease surveillance, infectious diseases are listed singly along with broad categories such as diseases of the heart. There is no one single best cause list of mortality. A given causal category may not qualify for all countries as a leading cause. Cause groups should be need determined. In consideration of these problems, a progressive structural approach and a new ICD--9 was recommended by PAHO in 1988. 6 principles were identified: hierarchy, comparability, expandability, consistency, suitability for identification of leading causes of death, and responsiveness to public health needs. The new short list is comprised of 61 all-inclusive categories in 6 broad cause groups (communicable diseases, neoplasms, diseases of the circulatory system, certain conditions originating in the neonatal period, external causes of injury and poisoning, and all other diseases, as well as symptoms, signs, and ill-defined conditions (SSI). The provision for SSI means data can be limited to defined causes only and if SSI becomes too large, a reappraisal is in order. This 6-group causal structure has been helpful in epidemiologic mortality patterns in the Americas, where communicable diseases (including influenza and pneumonia) rank in t he 5 leading causes of death. This was possible because of the modification of the communicable disease list to include all infectious and parasitic diseases, meningitis, and acute respiratory infections.
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PMID:Communicable disease mortality: now you see it, now you don't. 180 90

National mortality and hospitalization data from the Netherlands were analysed for asthma (International Classification of Diseases) (ICD 493), acute bronchi(oli)tis (ICD 466), pneumonia and influenza (ICD 480-487), and other chronic obstructive pulmonary diseases (ICD 490 + 491 + 492 + 496) in children aged 0-14 yrs for 1980-1987. No trends were seen in the mortality in age groups 0-4 yrs and 5-14 yrs, which actually concerned small numbers. In general a tendency towards increasing hospital admission rates for respiratory diseases was observed in both sexes in age groups 0-4 yrs and 5-9 yrs but not in age group 10-14 yrs, and significant increases were found for asthma in males and females aged 0-4 yrs and in males aged 5-9 yrs, and for acute bronchitis in females aged 5-9 yrs. Hospital admission rates in the Netherlands for asthma appeared to be low compared to other countries. The average length of stay, however, for both asthma and the other respiratory diseases was substantial though declining. Clinical information is required on possible causal factors of the apparent need for hospitalization for reactive airway disorders in young children, and on the management of asthma in particular.
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PMID:Mortality and morbidity from respiratory diseases in childhood in The Netherlands, 1980-1987. 185 71

The current approach in cardioverter-defibrillator implantation requires placement of epicardial leads which may lead to pericardial and/or pleural effusion and pneumonia during the perioperative period. Although ICD implantation is less invasive than other surgical techniques for the treatment of rhythm disturbances, the perioperative mortality must be considered. Minimizing the operative procedure could lead to a reduction in perioperative mortality. Therefore, we investigated an approach without the need for thoracotomy using a transvenous/subcutaneous lead system. In nine patients with prior cardiac surgery, defibrillator implantation was performed by a transvenous/subcutaneous approach. There was no perioperative mortality. In all patients, a sufficient defibrillation threshold was achieved. The defibrillation pulses were delivered as two sequential pulses between a right ventricular electrode (cathode) and a coronary sinus or superior caval vein electrode (anode 1) and a subcutaneous patch electrode (anode 2). Intubation of the coronary sinus was necessary in 4 patients in order to obtain satisfactory defibrillation thresholds. These data demonstrate that a transvenous/subcutaneous approach is feasible in patients with prior cardiac surgery obviating the need for thoracotomy. Sensing function of the RV-electrode, intubation of the coronary sinus and the intraoperative use of an epicutaneous patch electrode are current problems of this new technique.
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PMID:Implantable cardioverter/defibrillators (ICD): a new lead-system using transvenous-subcutaneous approach in patients with prior cardiac surgery. 149 34

We investigated the feasibility of using hospital discharge diagnoses of ICD codes 506, 507, and 508, respiratory diseases from external sources, to identify occupational sentinel health events [SHE(O)]. Two hundred sixty-nine records were reviewed and 66 (25%) were incidents where the work-relatedness of the respiratory diseases was documented in the medical records. Twenty-six percent of the 269 records contained no exposure information. Sixty-four of the 66 occupational cases were from ICD codes 506.0-506.9, with the largest number classified as ICD codes 506.0 (bronchitis and pneumonitis due to fumes and vapors) and 506.3 (other acute and subacute respiratory conditions due to fumes and vapors). We conclude that surveillance of ICD codes in the 506 series, where 39% of the cases were secondary to occupational exposures, is a valuable component of a surveillance system for preventable occupational lung disease.
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PMID:Acute occupational respiratory diseases in hospital discharge data. 205 78

This study examined the differences in mortality rate among the three ethnic groups aged 35 to 69: 1) Japanese living in Kawasaki city, 2) Koreans living in Kawasaki city, 3) Koreans living in Korea. Three different measures were used for analysis: 1) mortality rate by sex and age, 2) Mantel-Haenszel Rate Ratio (MHRR), 3) Standardized Proportional Mortality Ratio (SPMR). Major findings were as follows: 1) In terms of mortality rate by sex and age, Koreans in both Kawasaki and Korea showed higher mortality rates than Japanese in Kawasaki for both sexes and for all of the age categories. Koreans living in Kawasaki and Koreans living in Korea showed nearly identical levels of mortality rate for both sexes and for all of the age categories. 2) Calculation of MHRR utilizing a mortality rate for Japanese living in Kawasaki as 1 yielded the following: For all causes of death, MHRR of Korean males living in Kawasaki aged 35 to 59 was 2.59, and 2.37 for ages 60 to 69. For females MHRR for those age groups were 1.91 and 2.06 respectively. All of these MHRRs were statistically significantly high (p less than 0.05). 3) Among the causes for the high MHRR for Korean males living in Kawasaki aged 35 to 59 compared in Japanese living in Kawasaki were the following: all Malignant neoplasms (ICD 9, 140-208), Malignant neoplasm of liver (155), Hypertensive disease (401-405), Ischemic heart disease (410-414), Pneumonia (480-486), Liver Cirrhosis (571). For males aged 60 to 69, causes were Tuberculosis (010-018), all Malignant neoplasms, Malignant neoplasm of liver, Ischemic heart disease, Disease of the pulmonary circulation and other forms of heart disease (415-429), Cerebrovascular disease (430-438), and Liver Cirrhosis. In the case of females, Tuberculosis, Disease of the pulmonary circulation and other forms of heart disease, Malignant neoplasm of trachea, bronchus and lung were causes for high MHRR for Koreans in Kawasaki aged 35 to 59. All Malignant neoplasms, Malignant neoplasm of liver, Malignant neoplasm of trachea, bronchus and lung, Accidental causes of death except motor vehicle accidents (E800-807, E826-848, E850-949) were causes for females aged 60 to 69. 4) The mortality rates for ages 35 to 69 for both sexes are similar for both Koreans living in Kawasaki and in Korea.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[A mortality study of middle-aged and elderly Koreans in Kawasaki City in comparison with Koreans in Korea and Japanese in Kawasaki City]. 213 81


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