Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sera of healthy and sick persons were tested for the presence of secretory IgA (SIgA) and free secretory component (SC) SIgA was present in the blood of healthy persons in low concentrations (1.07 mg/100 mg), and free SC was absent. Infectious and somatic diseases, in which damage of the epithelial covering of the gastrointestinal and respriatory tracts was possible, were accompanied by increased blood SIgA content. There was also noted a distinct relationship between the blood SIgA concentration and the severity of infectious diseases and pneumonia supervention. In these cases the SIgA level proved to rise.
 ...
PMID:[Secretory immunoglobulin A in the blood sera of healthy and ill persons]. 91 27

Relative to a particular level of female mortality, male mortality is lower than expected, currently and historically, in Northwestern Europe, Southeastern Europe, and Tropical Latin America; it is higher than expected in Western-Central Europe and in the Far East. The geographical pattern of differentials is attributable primarily to variation in the masculinity of mortality from cardiovascular diseases, neoplasms, and influenza/pneumonia/bronchitis. Over time, male mortality has increased relative to a particular level of female mortality, and these same causes of death are principally responsible. In the 1960's, high masculinity of mortality was associated independently with low proportions in primary activities, high proportions hiring in large cities, and with high discrimination against females in school enrollment combined with poor nutritional standards. The former two variables once again operate primarily through cardiovascular disease, neoplasms, and the respiratory diseases, whereas the discrimination-nutrition interaction appears to operate through infectious diseases. Variations in levels of economic modernization are capable of accounting for a substantial portion of the regional differences, although certain constitutional factors such as physiotype are also plausibly implicated, and they are also congruent with trends in sex mortality differentials.
 ...
PMID:[Causes of death responsible for international and intertemporal variation in sex mortality differentials]. 93 40

Six cases of miliary pneumonia are reported, in which the marked increase in antibody titers showed that Mycoplasma pneumoniae was the probable cause. The clinical picture of these patients showed an acute and severe onset, with the appearance of diffuse alveolitis. The outcome of the disease depended on the time of initiation of treatment in relationship to the onset of symptoms. One case was seen to progress to fibrosing alveolitis with persistent impairment of diffusion. This observation suggests the possibility that some cases of pulmonary fibrosis of unknown aetiology may be due to previous mycoplasmal infection.
Infection 1976
PMID:Miliary mycoplasmal pneumonia: a report of six cases. 95 95

The in vitro transformation of lymphocytes stimulated by a Mycoplasma pneumoniae preparation was measured by the uptake of 14C-thymidine. The lymphocytes from five patients with M.pneumoniae pneumonia showed a high degree of responsiveness when they were compared to the lymphocytes taken from eleven healthy control subjects who lacked M.pneumoniae antibodies. Another four patients with an acute affection of the central nervous system and serological evidence of an actual or recent M.pneumoniae infection had a lymphocyte response within the same range as that of the controls. The transformation of lymphocytes was studied at intervals for seven months after the onset of the illness in one of the patients with pneumonia. These studies showed an increasing response to a small dose of mycoplasma antigen. Lymphocyte transformation induced by other microbial antigens was studied in three pneumonia patients during and after convalescence. The first responses were low and increased more steeply than the response to M.pneumoniae. The later responses to the mycoplasmal and to the other microbial antigens increased in parallel. The usefulness of incorporating other microbial antigens in the evaluation of the patient's immune response to a relevant antigen in this type of experiment is discussed.
Infection 1976
PMID:Lymphocyte transformation studies in Mycoplasma pneumoniae infections. 95 97

A comparative study was undertaken in order to ascertain the effects of a Mycoplasma pneumoniae infection on pulmonary function. It appears that the literature has many articles devoted to the clinical symptomatology of this type of infection but there is very little information available on the abnormalities which occur in the lungs with this infection. The patients who were used as a comparative model had lung lesions which gave a similar radiographic appearance. The significant finding was that an obstructive syndrome with increased airway resistance was noted in the M.pneumoniae pneumonia patients.
Infection 1976
PMID:The results of pulmonary function tests in patients infected with Mycoplasma pneumoniae. 95 6

Nine children between the ages of seven to 12 were studied. All of these children had an acute unilateral pneumonia caused by Mycoplasma pneumoniae. Regional pulmonary function studies were performed with the aid of an Xe133 radio-spirometry. It was shown with this technique that the ventilation of the infected part was more reduced than the perfusion during the acute stage. Fourteen to 22 days after the onset of the disease three children had normal chest X-rays but abnormalities of the pulmonary function tests. In one child this abnormal function persisted at the third follow-up some months later. By the use of regional pulmonary function studies subtle abnormalities can be observed which would normally be overlooked when examining the pulmonary function of both lungs.
Infection 1976
PMID:Pulmonary function in children with Mycoplasma pneumoniae pneumonia. 95 7

The causes of mortality and frequency of diseases were tabulated in 304 autopsies performed at Hopital Mama Yemo, Kinshasa, between July 1973 and December 1974. 78 of these autopsies were performed on subjects who died at Hopital Mama Yemo, 36 encompassed subjects from other hospitals, and 190 were of medicolegal cases in which the cause of death was not apparent from external examination. Men comprised 63.5% of autopsied cases. The mean age was 30.19 +or- 1.31 for men and 19.84 +or- 1.76 for women. 16.8% of deaths were due to homicide, 6.3% to suicide, and 8.9% to accidents, yielding an overall prevalence for trauma of 32%. Cancer accounted for only 3% of deaths, and cardiovascular diseases 8.2%. Bacterial infections (predominantly streptococcal disease, lobar pneumonia, and pulmonary tuberculosis) represented the largest single cause of death (17.4%). Parasitic infections comprised a further 6.3% of mortality and viral infections 7.2%, giving infectious diseases a combined frequency of 30.9%. Metabolic diseases were responsible for an additional 11.8% of deaths. Obstetric causes were identified in 3.9% of fatalities, and 95% of these cases represented hemorrhagic and septic complications of illegal abortion. Neonatal deaths (4.3%) were largely due to pneumonitis from aspirated amniotic fluid. A final 5.9% of deaths were unexplained. Also analyzed were cases of sudden death occurring outside the hospitals. 31.3% of these deaths were attributed to cardiovascular diseases and 46.3% to infection (including 2.5% due to septic abortion). Finally, the frequency of major diseases in this series was tabulated. Malaria was most frequently found (41.8%), followed by intravascular erythrocytic sickling (18.3%) and hypertension (16%). 12% of females in this series (20% of those dying traumatically) showed evidence of pelvic inflammatory disease. This series is considered to overestimate the frequency of trauma because of the large number of medicolegal cases that fall in this category. This selection for trauma further led to an oversampling of adult men. Nonetheless, it represents the 1st and best qualitative estimate of disease mortality and prevalence in Zaire. The trends in mortality and morbidity identified through this study provide a basis for planning health care and health education.
 ...
PMID:Autopsy analysis of disease frequency in Kinshasa, Republic of Zaire. 96 86

Complement fixation (CF) and passive hemagglutination (PHA) tests (the latter with a M. pneumoniae antigen coupled by glutaraldehyde onto red blood cells) were performed in 263 patients with various infectious diseases (mostly in the 1st and 2nd week after onset) and non-infectious ones. CF reaction proved to be inappropriate for the early etiological diagnosis of mycoplasma infections, since the high titers were distributed undifferentially among the various patient groups and many sera (38%) showed anticomplementary activity. A PHA titer of at least 1/128 (preferably of 1/512) points to the presence of a M. pneumoniae infection, especially if clinical, radiological and laboratory data suggest a nonbacterial or mixed pneumonia. The diagnosis is often early enough to orientate the etiological therapy towards macrolides and tetracyclines. The PHA reaction recommended is specific, sensitive, reproducible and easy to perform.
 ...
PMID:Passive hemagglutination and complement fixation reactions in the early diagnosis of Mycoplasma pneumoniae infections. 100 81

A study was carried out to determine whether the preexisting decline in mortality rates from infectious diseases accelerated after the introduction of antibiotic and chemotherapeutic drugs. Linear regression curves showed that in Sweden mortality rates declined faster in septicemia, syphilis, and non-memingococcal meningitis after the introduction of these drugs. By contrast, for the ten other infectious diseases studied, (scarlet fever, erysipelas, acute rheumatic fever, puerperal sepsis, meningococcal infection, bronchitis, pneumonia, tuberculosis, typhoid fever, and acute gastroenteritis) no such accelerated decline in mortality could be detected. The findings suggest that antibiotic and chemotherapeutic drugs have not had the dramatic effect of the mortality of infectious diseases popularly attributed to them.
 ...
PMID:The effect of antibiotics on mortality from infectious diseases in Sweden and Finland. 100 14

Prostaglandin concentrations of cerebrospinal fluid (CSF) of 38 febrile patients (from infants up to adults) were compared with those of 19 afebrile adult control persons. CSF samples were extracted and the prostaglandins groups of the extract separated by column chromatography. Concentrations of prostaglandins of the E and F series were estimated by radioimmunoassay. In CSF of all feverish patients with meningitis, pneumonia, or pyelonephritis about 2-fold higher concentrations of prostaglandin E (PGE) were found that in those of the afebrile control persons. In contrast, concentrations of prostaglandin F (PGF) in adults and infants remained largely unchanged during fever; Solely, in 4 of the 8 babies examined, concentrations of PGF were also increased besides those of PGE. Repeated estimations of prostaglandin concentrations in CSF from the same patients showed, that concentrations of PGE, which had been elevated during fever, normalized after defervescence. The height of fever and the concentrations of PGE in CSF tended to correlate in a dose related manner. In correspondence with the results of animal experiments prostaglandins of the E series seem to act as mediators of fever during infectious diseases also in man.
 ...
PMID:Prostaglandins as possible mediators of fever genesis in man. 101 27


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>