Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032285 (pneumonia)
 54,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of Chilaiditi's syndrome are reported. Case 1: A 56-year-old woman was admitted with dysphagia. She had been suffering from progressive systemic sclerosis for 16 years. Three years before the admission, dysphagia developed and dilatation and hypomotility of the esophagus were observed. Chest and abdominal x-ray films on admission showed severe dilatation of the intestine, pneumatosis cystoides intestinalis, abdominal free air, and Chilaiditi's syndrome. Chilaiditi's syndrome and other signs disappeared after conservative treatment. She died four months later due to cor pulmonale. Case 2: An 87-year-old man was admitted with constipation and left lower abdominal pain. Physical examination showed ascites. Chest and abdominal x-ray examination showed Chilaiditi's syndrome. Cytological examination of ascites revealed adenocarcinoma cells. Diagnosis of peritonitis carcinomatosa due to cancer of pancreatic tail was made. Chilaiditi's syndrome disappeared after removal of ascites. Case 3: A 71-year-old bedridden man who had urinary incontinence developed meterorism. Repeated chest x-ray examinations constantly showed Chilaiditi's syndrome. He died of pneumonia two years later. The pathogenesis of Chilaiditi's syndrome was discussed and the literature was reviewed.
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PMID:[Three cases of Chilaiditi's syndrome--hepatodiaphragmatic interposition of the colon]. 143 56

Preexisting lung disease was examined as a risk factor for lung cancer in a population-based, case-control study of nonsmoking women in Missouri conducted between June 1, 1986, and April 1, 1991. A history of lung disease was reported by approximately 41% of 618 cases and 35% of 1,402 controls (odds ratio (OR) = 1.2; 95% confidence interval (Cl) 1.0-1.5. The risk was more pronounced when next-of-kin interviews were excluded (OR = 1.5). Previous lung disease was significantly related both to adenocarcinoma (OR = 1.4), which accounted for 62% of the cancers, and to all other cell types of lung cancer combined (OR = 1.8). Despite having discontinued smoking for more than 15 years, long-term ex-smokers were at a 2.2-fold risk of lung cancer compared with lifetime nonsmokers. Among lifetime nonsmokers, significant risks were noted for asthma (OR = 2.7) and pneumonia (OR = 1.5). Emphysema (OR = 2.6) and tuberculosis (OR = 2.0) were also significantly related to lung cancer, but only among former smokers. Chronic bronchitis was linked to elevated risks of nonadenocarcinomas only (OR = 2.3). Pleurisy was not reported more frequently by cases than by controls. Approximately 16% of all lung cancers among nonsmoking women could be attributed to previous lung diseases, most notably asthma, pneumonia, emphysema, and tuberculosis.
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PMID:Preexisting lung disease and lung cancer among nonsmoking women. 144 29

We report on a 67-year-old man with Felty's syndrome (FS) complicated by recurrent pneumonia and an infected wound, which was not healing in spite of maximal antibiotic and local therapy. Encouraged by previous experience, we treated him with granulocyte-macrophage colony-stimulating factor (GM-CSF). His total leukocyte count rose, but the patient's pneumonia deteriorated. In addition, a previously known chronic obstructive lung disease (COLD) was exacerbated acutely. These complications finally led to his death. Postmortem examination revealed widespread pneumonia with invasive aspergillosis and a peripheral adenocarcinoma in his left lung.
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PMID:Treatment of neutropenia in Felty's syndrome with granulocyte-macrophage colony-stimulating factor--hematological response accompanied by pulmonary complications with lethal outcome. 145 82

One of six patients in a 1960 paper on "Cerebellar syndrome in myxoedema" was subsequently found to have adenocarcinoma. General post-mortem revealed carcinomatosis and basal pneumonia. Neuropathological examination revealed the changes of multiple system atrophy. The relationship between hypothyroidism, carcinoma, and cerebellar, pontine and striatonigral degeneration is discussed.
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PMID:Cerebellar syndrome in myxoedema revisited: a published case with carcinomatosis and multiple system atrophy at necropsy. 164 Feb 41

The importance of smoking and other factors for lung cancer in women was investigated in a case-control study of women who had previously received a multiphasic health checkup at Northern California Kaiser Hospitals. Smoking and medical histories for 217 cases and matched controls were obtained from the multiphasic questionnaire. Odds ratios (ORs) and confidence intervals (CIs) associated with cigarette smoking were 35.1 (95% CI 4.8-256) for squamous and small cell and large cell carcinomas combined and 2.5 (95% CI 1.3-5.1) for adenocarcinoma. After adjusting for smoking, risk was increased in women with a family history of lung cancer (OR 1.9, 95% CI 0.7-5.6) and family history of any cancer (OR 1.8, 95% CI 1.0-3.2). A significant interaction existed between smoking and family history. Women with a history of bronchitis, pneumonia, or emphysema were at increased risk, whereas women with a history of asthma or hay fever experienced a significantly lower risk for lung cancer.
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PMID:Lung cancer in women: the importance of smoking, family history of cancer, and medical history of respiratory disease. 165 3

From 1955 to April 1989, 70 patients underwent bilobectomy for the treatment of primary lung carcinoma. Thirteen patients (18.6%) underwent right upper and middle lobectomy (UML), while 57 patients (81.4%) underwent right middle and lower lobectomy (MML). Indications for bilobectomy were cancer invasion into intermediate bronchus (34%), tumor extending to neighbouring lobe across a fissure (29%), interlobar lymph nodes metastasis with or without invasion to intermediate bronchus (24%), vascular invasion (5%), and others (7%). Squamous cell carcinoma was present in 31 patients, adenocarcinoma in 28, large cell carcinoma in 5, small cell carcinoma in 4 and others in 2. About 60 percent of the patients had Stage III or IV diseases. Postoperative complications occurred in 27 patients (38.6%) and 3 died within 30 days after operation (operative mortality rate. 4.3%). Pneumonia, empyema, atelectasis and arrhythmia were prominent postoperative complications. There were no statistically different postoperative complication rates between those with UML and those of MLL. Five-year survival rate of the patients with bilobectomy for lung cancer was 25.7%, which was between those with single lobectomy (36.9%) and those with pneumonectomy (5.6%). However, there was no statistical difference in 5-year survival rate among operative procedures in each stage.
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PMID:[An analysis of 70 patients with bilobectomy for bronchogenic carcinoma]. 165 64

As local treatments other than surgery, radiation therapy, bronchial artery infusion and intrabronchial injection of anti-cancer drugs have generally been administered to inoperative lung cancer cases. Together with these local therapies, we experienced six cases of intramediastinal injection. Indication of this therapy has been fundamentally limited to the inoperative cases in which patient performance status has deteriorated. Histologically, three cases were squamous cell carcinoma and three cases were adenocarcinoma. Injection therapy was effective in four cases where we noted alleviation of atelectasis and obstructive pneumonia brought on by the tumor, and a tendency of the tumor and swelling lymph nodes to be reduced. No side effects nor complications were evidenced. This therapy is characterized by a wider injection area in which intrabronchial injection is incapable of reaching the upper mediastinum, the bifurcation and the upper side of the hilus. The results suggest that this therapy should be used alone or together with other local therapies and prior to operation.
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PMID:[Clinical experience of intramediastinal injection therapy via mediastinoscope for lung cancer]. 192 Oct 2

We report temporal bone pathology in a 25-year-old man with bilateral temporal bone adenocarcinoma which was caused by metastasis from a primary lesion in the pancreas. The initial symptoms began with vertigo and headache and the patient noticed left hearing loss in the left ear on the following day. A few days later, he noticed hearing loss in the right ear, and bilateral hearing was totally lost within two weeks of the onset. In addition to severe bilateral sensorineural hearing loss, left IInd, bilateral Vth and VIIIth cranial nerve paralysis occurred. Brain CT showed multiple metastatic lesions in the brain. The patient's general condition rapidly deteriorated, and he died of acute pneumonia on the 42nd day after onset. At autopsy it was revealed adenocarcinoma of the tail and body of the pancreas and its metastasis to the brain and meninges. Pathological study of the temporal bone showed infiltration of carcinomatous cells along the VIIth and VIIIth nerves in the bilateral internal auditory canals.
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PMID:[A case of bilateral sudden hearing loss and vertigo caused by bilateral temporal bone metastasis from pancreatic carcinoma--comparison of clinical findings and temporal bone pathological findings]. 201 18

The authors report a case of a patient aged 83 who presented with a lipid pneumonia and a primary broncho-pulmonary adenocarcinoma of the left lower lobe. The diagnosis of the lipid pneumonia was confirmed following broncho-alveolar lavage and the autopsy confirms the neoplastic origin of the mass lesion at the left base. The authors report 16 similar cases in the literature between 1943 and 1989.
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PMID:[Lipid pneumopathy and bronchopulmonary adenocarcinoma. Apropos of a case]. 203 43

To evaluate the sensitivity of computed tomography (CT) in detecting multicentric primary bronchogenic adenocarcinoma manifesting as a pulmonary nodule, the authors reviewed CT scans and pathologic specimens of 158 consecutive patients who underwent resection of a pulmonary nodule. Two independent observers assessed the scans without knowledge of the pathologic findings. Lung specimens were fixed in inflation and sectioned transversely, analogous to the plane of the CT scans. In 88 patients the nodule represented adenocarcinoma. Multicentric adenocarcinoma was present in 19 of these patients (22%). The sensitivity of CT in correctly detecting the presence and location of two or more lesions was 0.63 and 0.68 for two observers, with a specificity of 0.86 for both. The CT appearance of multicentric disease varied from well-defined nodules to ill-defined hazy opacities simulating pneumonitis. The data indicate that (a) multicentric adenocarcinomas are more common than generally reported in the literature and (b) meticulous evaluation of CT images enables detection of multicentricity in a high percentage of cases.
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PMID:Multicentric adenocarcinoma of the lung: CT-pathologic correlation. 216 69


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