Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0032273 (
pneumoconiosis
)
1,578
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Silicosis is a kind of
pneumoconiosis
caused by inhalation of silica dust, which is characterized by lung fibrosis. The biologically active form of transforming growth factor-beta1 (TGF-beta1) plays a key role in the development of lung fibrosis.
CD36
is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1. The antagonistic effect of the synthetic peptide was analyzed by the administration of
CD36
(93-110) synthetic peptide to the silicosis model of mice. The hydroxyproline content of the silica +
CD36
(93-110) synthetic peptide group was significantly lower than that of the other experimental groups [silica and silica +
CD36
(208-225) synthetic peptide groups] (p < .05). Inflammation, fibrotic degree and distribution of collagen fibers in silicotic nodules of the silica +
CD36
(93-110) synthetic peptide group were less than those of the other experimental groups. The expressions of collagen I and III of the silica +
CD36
(93-110) synthetic peptide group were significantly lower than those of the other experimental groups (p < .05).
CD36
(93-110) synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the silicosis model of mice, resulting in the decreased severity of silica-induced lung fibrosis.
...
PMID:A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice. 2005 42
