Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alveolar macrophages (AM) represent a lung border system bringing about the protection of the organ from the environmental hazards, regulating cell and humoral response in the lungs, and eliminating endogenous toxic substances. However, in some situations AM are involved in the pathologic processes and even may serve as an initiating factor in the development of lung pathology. They realize their pathogenic effect in the bronchial asthma, acute respiratory distress-syndrome, pneumoconiosis releasing various biologically active compounds which take part in the formation of bronchial hyperreactivity, chemotaxis disturbances, haemostasis pathology. Particularly interesting is the possibility of lung tissue damage by AM when they interact with endotoxin-positive granulocytes.
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PMID:[Alveolar macrophages in lung physiology and pathology]. 187 89

The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avoiding extensive tissue damage. Nucleotide-binding oligomerization domain-like receptors (NLRs) represent a group of key sensors for microbes and damage in the lung. As such they are important players in various infectious as well as acute and chronic sterile inflammatory diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD), acute lung injury/acute respiratory distress syndrome, pneumoconiosis, and asthma. Activation of most known NLRs leads to the production and release of pro-inflammatory cytokines, and/or to the induction of cell death. We will review NLR functions in the lung during infection and sterile inflammation.
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PMID:NOD-Like Receptors in Lung Diseases. 2431

Methamphetamine is a substance of abuse that is most commonly smoked. Both regular and non-regular use can cause toxic injury to the lung parenchyma, the signs and symptoms of which are non-specific. Clinical scenarios include non-cardiac pulmonary oedema, acute respiratory distress syndrome, alveolar haemorrhage, pneumonia and pneumoconiosis. As radiological imaging is often non-specific, a positive history of methamphetamine use is the only way to reach a definite diagnosis. The use of methamphetamine is now increasing in Europe, so it is important as physicians to be aware of this differential diagnosis in patients in respiratory distress with risk factors for illicit drug use.
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PMID:Methamphetamine-Induced Lung Injury. 3129 88