Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many types of dust, including cigarette smoke, cause an impairment of lung function. This lung function impairment does not affect working capacity provided the dust is not fibrogenetic. Quartz, normally present in coal mine dust in concentrations between 2 and 10% is claimed to be responsible for coal workers' pneumoconiosis (CWP) by some writers. However the evidence is conflicting and firm conclusions cannot be drawn at present. From the clinical point of view CWP is characterized by an increased airway resistance. All correlations between airway resistance, arterial oxygen and carbon dioxide pressure and intrathoracic gas volumes (IGV) in patients having CWP and obstructive airway disease are similar to those in non-dust exposed patients with obstructive ariway disease. Patients with CWP, at equivalent values of airway resistance have smaller mean values of IGV. The relationship between arterial oxygen pressure and pulmonary arterial pressure is the same in patients with CWP and obstructive airway disease as in patients with chronic obstructive airway disease but without CWP. The effect of therapy in CWP with obstructive airway disease corresponds very well to that seen in patients without CWP.
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PMID:Chronic obstructive airway disease in pneumoconiosis in comparison to chronic obstructive airway disease in non-dust exposed workers. 121 48

Restriction fragment length polymorphism (RFLP) in the alpha 1-antitrypsin gene region was studied in relation to chronic obstructive airway disease (COAD) and pneumoconiosis. Genomic DNA of 122 studied subjects was digested with Hind III restriction endonuclease and hybridized with the alpha 1-antitrypsin gene probe. In eight patients with COAD an unusual 10-kb restriction fragment was found hybridizing with the probe. Three of 70 patients were homozygotes for this variant allele and 5 were heterozygotes, showing the presence of two fragments, 2.7 kb and 10 kb. The presence of 10-kb restriction fragment seems to be related to the early development of COAD in studied subjects and therefore might be used as a genetic marker of the disease.
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PMID:Alpha 1-antitrypsin gene polymorphism related to respiratory system disease. 288 93

We report a 65 year old female patient who had presented with dry cough and shortness of breath for the last 5 years and had also received anti-tubercular therapy but without any benefit. Evaluation revealed the presence of obstructive airway disease with nodular opacities in bilateral lungs. Histopathological examination including electron microscopy was suggestive of domestically acquired pneumoconiosis.A diagnosis of Gujjar lung was made based on history of exposure to wood smoke, characteristic histological and radiological features. Anti-tubercular therapy was stopped and bronchodilators were initiated along with removal from source of exposure to which she showed significant improvement. We also did a systematic review of literature pertaining to Gujjar lung.
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PMID:Gujjar Lung: An Unusual Case Report and Systematic Review of Literature. 3192 Feb 64