Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activity of neutrophilic elastase and the level of its major inhibitor--an alpha 1-inhibitor of proteinases were studied to evaluate the protease-antiprotease system in the bronchoalveolar lavage fluid (BALF) of patients with chronic dust-induced bronchitis (CDB) and pneumoconiosis (PC). It was found that CDB, as compared with PC, was characterized by a higher elastase activity in the BALF (70%) and that there were a larger number of patients with elastase activity (40%), which correlated with the detection rate of emphysema. Free elastase activity and relative proteinase alpha 1-inhibitor deficiency suggest that the BALF protease-antiprotease system is impaired in patients with CDB and PC, which is more pronounced in patients with CDB.
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PMID:[Impaired balance of the lung proteolytic system in patients with pneumoconiosis and chronic dust-induced bronchitis]. 1452

One of objective methods of early and differential diagnosis of occupational pulmonary diseases in miners (pneumoconiosis, silicotuberculosis, dust bronchitis) is bronchoscopy with a cytologic examination of bronchoalveolar lavage fluid (BAF). BAF-examination was carried out in a total of 88 patients with incipient and advanced forms of dust bronchitis, pneumoconiosis and silicotuberculosis. A direct relationship has been revealed between a decline in local cell-bound immunity caused by a dust-inducted affection mononuclear phagocytes and advancing of stages of dust-related diseases.
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PMID:[Bronchoalveolar lavage in the diagnosis of occupational pulmonary diseases in miners]. 1461 22

Unfavorable hygienic factors, like nickel-containing dust, toxic gases, resinous sublimates, heat and hard physical labor are inherent in the modern production of nickel. A variety of occupational peculiarities results in a higher morbidity of workers. Diseases of the respiratory organs, digestive system, skin and of the subcutaneous cellular tissue are in the lead. Besides, bronchitis, pneumoconiosis, exogenous fibrosing alveolitis as well as neoplasms in the respiratory organs and stomach equally belong to occupational diseases. Preventive schemes of the general occupational and oncological morbidity of workers must rest on a comprehensive set of measures with the introduction of new technological innovations and of raw materials into all nickel-production stages being of primary importance.
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PMID:[Labor hygiene in the fire production of nickel]. 1510 74

Exposures to fibers and particles can be associated with several different lung injuries including bronchitis, bronchiolitis, pneumonitis, pleuritis, pulmonary alveolar proteinosis, pneumoconiosis, mesotheliomas, and lung cancers. The mechanism of biological effect exerted by fibers and particles has not been exactly defined. Exposures to all fibers and particles introduce a solid-liquid interface into the lower respiratory tract. These surfaces all have some concentration of oxygen-containing functional groups that demonstrate a capacity to coordinate iron. Radical generation is catalyzed by this metal resulting in a cascade of cell signaling, transcription factor activation, and mediator release. We propose that the ferruginous body (i.e., a fiber or particle with a coating of both protein and iron) provides direct evidence of a participation of iron in the biological effect of both fibers and particles. It is recommended that an identification of ferruginous bodies in the lung be regarded as support for a metal-catalyzed oxidative stress in the mechanism of cell and tissue injury.
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PMID:Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. 1551 7

The authors demonstrated efficiency of aerosol therapy using "Dovolenskaya" mineral water in treating patients with occupational pulmonary diseases. Results are improved bronchial drainage, normal pro- and antioxidant status, lower inflammatory activity in patients with pneumoconiosis and occupational dust bronchitis.
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PMID:[Efficiency of aerosol therapy in rehabilitation programs for patients with occupational broncho-pulmonary diseases]. 1765 70

The article covers contemporary data on structure of occupational pulmonary diseases, vital and disputable clinical and diagnostic topics on major entities: pneumoconiosis, occupational bronchitis and occupational bronchial asthma. The most prospective research trends are outlined.
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PMID:[Topical problems of occupational pulmonary diseases and prospective research trends]. 1780 16

Results of complex study determining levels of IL-1-4-6 and TNO in bronchoalveolar lavage and blood serum helped to justify nososlogic independence of dust bronchitis and its pathogenetic commonnes with pneumoconiosis--that confirms combining them into a group of dust respiratory diseases.
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PMID:[On pathogenetic unity of pneumoconiosis and dust bronchitis]. 1780 17

The analysis covered contemporary approaches to rehabilitation of patients having occupational respiratory diseases (pneumoconiosis, chronic dust bronchitis and their combination). The authors evaluate efficiency of therapeutic and rehabilitation measures.
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PMID:[Efficiency of rehabilitation for workers having occupational respiratory diseases and engaged into non-mining materials industry]. 1967 Apr 88

Analysis covered 1348 case histories of workers exposed to industrial dust in Urals region. The analysis applied mathematical processing of survival theory and correlation analysis. The authors studied influence of various factors: dust concentration, connective tissue dysplasia, smoking habits--on duration for diseases caused by dust to appear. Findings are that occupational diseases develop reliably faster with higher ambient dust concentrations and with connective tissue dysplasia syndrome. Smoking habits do not alter duration of pneumoconiosis development, but reliably increases development of occupational dust bronchitis.
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PMID:[Mathematic analysis of risk factors influence on occupational respiratory diseases development]. 2040 63

Ozone dynamics depend on meteorological characteristics such as wind, radiation, sunshine, air temperature and precipitation. The aim of this study was to determine ozone trajectories along the northern coast of Portugal during the summer months of 2005, when there was a spate of forest fires in the region, evaluating their impact on respiratory and cardiovascular health in the greater metropolitan area of Porto. We investigated the following diseases, as coded in the ninth revision of the International Classification of Diseases: hypertensive disease (codes 401-405); ischemic heart disease (codes 410-414); other cardiac diseases, including heart failure (codes 426-428); chronic obstructive pulmonary disease and allied conditions, including bronchitis and asthma (codes 490-496); and pneumoconiosis and other lung diseases due to external agents (codes 500-507). We evaluated ozone data from air quality monitoring stations in the study area, together with data collected through HYbrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model analysis of air mass circulation and synoptic-scale zonal wind from National Centers for Environmental Prediction data. High ozone levels in rural areas were attributed to the dispersion of pollutants induced by local circulation, as well as by mesoscale and synoptic scale processes. The fires of 2005 increased the levels of pollutants resulting from the direct emission of gases and particles into the atmosphere, especially when there were incoming frontal systems. For the meteorological case studies analyzed, peaks in ozone concentration were positively associated with higher rates of hospital admissions for cardiovascular diseases, although there were no significant associations between ozone peaks and admissions for respiratory diseases.
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PMID:Long-range ozone transport and its impact on respiratory and cardiovascular health in the north of Portugal. 2059 1


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