Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coal workers' pneumoconiosis impairment evaluations for 374 miners, predominantly from eastern Kentucky, were conducted by our department between January 1, 1989, and June 30, 1992. During a review of the cases, potentially significant findings not directly related to any detected pneumoconiosis were recorded. Sixty-five (17.4%) of the men had blood pressure > or = 150 mm Hg systolic or > or = 90 mm Hg diastolic during one measurement. Of 89 workers who had a previous diagnosis of hypertension and were being treated, 40 (44.9%) had an elevated blood pressure measurement. Twelve cases of incidental, previously undetected chest radiograph findings warranted follow-up; 9 of these were isolated pulmonary nodules. In addition, three patients were immediately referred for evaluation and treatment of conditions newly diagnosed during the examination--one for unstable angina pectoris, one for congestive heart failure, and one for recent cerebrovascular accident. These cases illustrate that physicians doing impairment evaluations, even if they are not the patient's treating physician, have the opportunity and responsibility to intervene and reduce morbidity and mortality.
 ...
PMID:Unexpected opportunities: incidental findings detected during impairment evaluations for coal workers' pneumoconiosis. 911 33

In order to investigate the general rules concerning attack, development and death of pneumoconiosis for providing scientific evidences for preventing, 1003 death cases of pneumoconiosis from Xuzhou coal mine factory were analyzed. Results showed that: (1) The death causes was in the sequence of pneumoconiosis, lung tuberculosis, chronic cor pulmonale, pulmonary carcinoma, etc., and changed into pneumoconiosis, chronic cor pulmonale, pulmonary carcinoma, cerebrovascular accident, etc. since 1990s. Lung tuberculosis would no longer be the main death cause of pneumoconiosis; (2) The accumulative death percentage of the death cases about pneumoconiosis was correlated to the length of dust exposure. The accumulative death percentage increased rapidly in a beeline within 5 to 20 years; (3) The length of service of episode and mean life of digging or mining workers were significantly shorter than that of others (P < 0.01); (4) The mean life and the course of diseases became more and more longer than ever since 1970s. Therefore, it can be concluded that the key for preventing and controlling pneumoconiosis was to decrease the concentration of dust in workplace and to limit the length of service of dust exposure.
 ...
PMID:[Analyses of 1003 death cases of pneumoconiosis from Xuzhou coal mines]. 1291 73

Although past studies have confirmed that chronic dust exposure is a risk factor for cardiovascular disease, the relationship between it and cerebrovascular disease is still unclear. We aimed to determine whether pneumoconiosis is related to increased incidence of ischemic stroke in the following 5 to 11 years. We selected 1238 patients with pneumoconiosis from Taiwan's National Health Insurance database as our study cohort. After matching for age, sex and the date of ambulatory care visit, another 4952 patients without pneumoconiosis were selected as the comparison cohort. Each patient was individually followed up until the end of 2010 to track the incidence of stroke, and Cox proportional hazard regression analysis was performed to compute the relative hazard ratio of stroke. Our results showed 19.6% of pneumoconiosis patients and 15.8% of non-pneumoconiosis patients developed stroke. After statistically adjusting for age, sex, and medical comorbidities, the hazard of developing stroke was 1.36 times greater for those with pneumoconiosis compared to those without. Even in those with pneumoconiosis excluding chronic obstructive pulmonary disease, the hazard of developing stroke was still 1.31 times greater than those without pneumoconiosis. Our study revealed that pneumoconiosis patients are at a higher risk of ischemic stroke, and primary prevention of stroke is particularly important in this group of patients.
 ...
PMID:Increased risk of ischemic stroke in patients with pneumoconiosis. 2549 6

We evaluated right ventricular function in patients with pneumoconiosis using real-time three-dimensional echocardiography (RT3DE). A total of 80 consecutive patients were prospectively recruited, 44 of whom were diagnosed with pneumoconiosis, and the remaining 36 age- and gender-matched healthy volunteers served as the control group. All patients underwent both 2D and 3DE. The tricuspid regurgitation pressure (TRPG), right ventricular anterior wall thickness and range of motion, right ventricular posterior wall thickness and range of motion, right ventricular end-diastolic volume, right ventricular end-systolic volume, and right ventricular ejection fraction (RVEF) were measured. The RVEF of healthy volunteers ranged from 50 to 78%, while the RVEF of pneumoconiosis patients ranged from 29 to 73%. TRPG influenced RVEF by 77.3% (P = 0.006) and showed a negative correlation (r = -0.643, P < 0.01). Volume-time curves (VTC) of patients with pneumoconiosis showed more troughs (low stroke volumes) than the VTCs of normal subjects. Evaluation of right ventricular function in patients with pneumoconiosis using RT3DE can provide additional clinical information.
...
PMID:Using volume-time curves with real-time three-dimensional echocardiography to analyze right ventricular function in patients with pneumoconiosis. 2550 Nov 78

Pneumoconiosis is a parenchymal lung disease that develops through the inhalation of inorganic dust at work. Cerebrovascular and cardiovascular events are leading causes of mortality and adult disability worldwide. This retrospective cohort study investigated the association between pneumoconiosis, and cerebrovascular and cardiovascular events by using a nationwide population-based database in Taiwan. The data analyzed in this study was retrieved from the Taiwan National Health Insurance Research Database. We selected 6940 patients with pneumoconiosis from the database as our study cohort. Another 27,760 patients without pneumoconiosis were selected and matched with those with pneumoconiosis according to age and sex as the comparison cohort. We used univariate and multivariate Cox proportional-hazard regression analyses to determine the association between pneumoconiosis and the risk of cerebrovascular and cardiovascular events after adjusting for medical comorbidities. After adjustment for age, sex, and comorbidities, the patients with pneumoconiosis exhibited a significantly higher incidence of ischemic stroke (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.05-1.24) than did those without pneumoconiosis. The incidence of hemorrhagic stroke was higher, but not significant, in the pneumoconiosis patients (HR 1.20, 95% CI 0.99-1.46). No statistically significant differences were observed between the pneumoconiosis and nonpneumoconiosis groups in acute coronary syndrome (HR 1.10, 95% CI 0.95-1.26). The findings of this study reveal an association between pneumoconiosis and a higher risk of cerebrovascular events after adjustment for comorbidities. Healthcare providers should control the related risk factors for primary prevention of stroke in pneumoconiosis patients.
 ...
PMID:Risk of Cerebrovascular Events in Pneumoconiosis Patients: A Population-based Study, 1996-2011. 2694 4