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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred ninety three patients with mediastinal and pulmonary sarcoidosis were assayed one or more than one time for seric angiotensin converting enzyme (SACE) using the method of Cushman and Cheung (substrate hippuryl-histidyl-leucin). Seventy one normal subjects and 163 patients with various broncho-pulmonary diseases excluding sarcoidosis were used as control. SACE is elevated in 67.2 p. 100 of the patients with sarcoidosis and reflects the intra and extrathoracic extend of the granuloma. Elevated levels of SACE in pneumoconiosis diminishes the diagnostic value of this test (as well as the presence of a normal SACE level in some sarcoid patients). There is no correlation between SACE and the percentage of lymphocytes in bronchoalveolar lavage fluid. SACE returns to normal in cases with spontaneous radiological improvement, and reaches more elevated levels in cases with worsening. An initial low level of SACE is usually a sign of a future good evolution. An initial high level is an argument for starting on steroid treatment. Repeated dosages of SACE are useful for monitoring the steroid posology at the end of the treatment and for deciding to stop it. Persistence of low levels allows to stop the treatment. Re-elevation of SACE may correspond to a radiological and clinical relapse or to an isolated and resolvent rebound.
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PMID:[Diagnostic, prognostic and developmental value of serum angiotensin converting enzyme in sarcoidosis]. 632 38

A chronic pulmonary granulomatous reaction was associated with an almost identical clinical picture in two patients exposed to talc. In both patients lung biopsy showed the deposition of talc particles and a heavy granulomatous reaction. At the time of diagnosis the Kveim test result was negative in both patients, urinary calcium excretion was normal, and there were no extrapulmonary manifestations and no response to steroid treatment. These findings point against sarcoidosis. The serum angiotensin-converting enzyme level, however, was raised in both patients. It was concluded that the patient who was exposed to talc in the rubber industry had a true talc pneumoconiosis. The other patient, who was exposed to cosmetic talcum powder, suffered from chronic sarcoidosis with talc deposition in the lungs, since an enlarged axillar lymph node containing granulomatous inflammation was discovered after two years' follow up. These cases show that it may be extremely difficult to differentiate between chronic sarcoidosis and talc pneumoconiosis even after careful clinical and histological analysis.
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PMID:Pulmonary granulomatous reaction: talc pneumoconiosis or chronic sarcoidosis? 669 39

Peripheral calcification of lymph nodes, "eggshell calcification," commonly occurs in patients with silicosis and coal-worker's pneumoconiosis. Sarcoidosis, postirradiation Hodgkin disease, blastomycosis, and scleroderma are other reported causes. Two not previously described causes, amyloidosis and histoplasmosis, are presented, and disorders that simulate eggshell calcification are listed. The explanation for the eggshell pattern of calcification is not known.
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PMID:Eggshell calcification of lymph nodes: an update. 677 37

The relation of expense to benefit of mass radiography (RRU) can no longer be referred to the tuberculosis discovery rate. Far more frequently other thoracic diseases are detected, e.g. tumors, cardiovascular diseases, pneumoconiosis, sarcoidosis, etc. The prerequisite and therefore the immediate objective is the limitation to the defined and detectable group of risks so as to increase the detection rate. In combination with other prophylactic investigations the benefit of RRU can still be increased -- it provides a valuable insight into the epidemiology of different social diseases.
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PMID:[Mass radiography. The "pros and cons" of a classic method of preventive medicine (author's transl)]. 678 Aug 19

1119 pulmonary biopsies (two thirds open) have been performed in 108 patients with signs of diffuse interstitial disease of the lung. The results showed 29 cases of fibrosing alveolitis, 4 of granulomatous alveolitis, 8 of diffuse interstitial fibrosis, 12 of eosinophilic granuloma, 12 of pneumoconiosis, 16 of sarcoidosis, and 38 with other pulmonary lesions. Biopsy via thoracotomy is the best diagnostic technique, with a 97.4% yield; with transparietal biopsies the yield is 81% and with transbronchial biopsies 60%. Histology permits exact diagnosis in all pneumopathies except fibrosing alveolitis. In this case the pathologist guides the clinician's investigations towards a search for an allergic etiology.
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PMID:[Pulmonary biopsy in interstitial pneumopathies]. 697 83

Two cases of nepheline rock dust pneumoconiosis are presented. Radiologically, this is seen as a diffuse increase in interstitial lung markings, lymphadenopathy, air-space disease, and atelectasis secondary to extrinsic compression by enlarged hilar lymph nodes. Major differential diagnoses include carcinoma of the lung, sarcoidosis, and interstitial lung disease caused by other inorganic dusts. Nepheline rock dust pneumoconiosis should be considered when the above radiological changes are observed and an occupational exposure to inorganic dust is documented.
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PMID:Nepheline rock dust pneumoconiosis. A report of 2 cases. 705 44

The chest roentgenogram is frequently used to judge severity and course of sarcoidosis. The only widely used method for staging, suggested by Siltzbach, does not provide for such judgments. Therefore, we devised a scheme for objective description of type and quantity of opacities based on the ILO/UC Classification for the Pneumoconioses. We added a "reticulonodular" category (x y z) to the present "rounded (p q r) and "linear-irregular" (s t u) categories. We retained the 11 point scale for profusion (severity) and added notations to describe ground glass (alveolar) patterns, size of nodes, and hilar retractions. Among 211 patients, x y z (35%) and p q r (33%) opacities predominated while s t u opacities (19%) were unusual. Radiographic severity correlated best with vital capacity (rs = -0.49) and the diffusing capacity (rs = -0.32). With the Siltzbach classification these correlations were not as good (rs = -0.27 and -0.19). Siltzbach Stage III (fibrosis) was a distinct group with poor function and frequent airway obstruction. There was no correlation between radiographic appearance and pathologic severity because the latter grading, on a scale from 0 to 10, never exceeded 3. Sequential studies in 64 patients showed that, when individuals are used as their own controls, overall profusion correlated highly with physiologic changes over time.
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PMID:A radiographic classification for sarcoidosis: physiologic correlation. 707 45

Solutions of 99mTc-diethylenetriaminepenta-acetate (99mTc-DTPA) and 99mTcO-4 were aerosolized and inhaled by subjects seated against a scintillation camera. Initial clearance rates of these radionuclides were determined over 6 posterior lung regions. Clearance of 99mTcO-4 (molecular weight, 163 dalton exceeded that of 99mTc-DTPA (molecular weight, 492 daltons) by an average factor of 3.3. Upper-lobe clearance of both radionuclides was greater than lower-lobe clearance in the normal subjects, but this gradient was abolished when the subjects exhaled against 7 cm of positive end-expiratory pressure. Twenty-one patients with clinical and roentgenographic evidence of interstitial lung disease (ILD) and diminished CO diffusion rates were studied with 99mTc-DTPA. Clearance of 99mTc-DTPA was increased in each of 5 patients with idiopathic pulmonary fibrosis, 4 of 8 with sarcoid, 2 of 5 with pneumoconiosis, and 2 of 3 patients with other forms of ILD. In contrast, the clearance of 99mTcO-4 was decreased in 4 patients with pulmonary alveolar proteinosis. Furthermore, no increase in 99mTc-DTPA clearance was found in 5 patients with chronic obstructive pulmonary disease. These studies suggest that the initial clearance of these aerosolized hydrophilic radionuclides is accomplished in part by diffusion through the epithelium of alveoli and respiratory bronchioles. Whereas radionuclide clearance is impaired by the presence of precipitated protein in these structures in pulmonary alveolar proteinosis, clearance is accelerated in ILD. This may indicate increased epithelial permeability in ILD related to injury and increased retractile forces.
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PMID:Accelerated clearance of small solutes from the lungs in interstitial lung disease. 735 93

Cryptogenic fibrosing alveolitis in Moravia and Silesia (4 million inhabitants) was evaluated using standard epidemiological and clinical parameters. During 1981-1990 the incidence of cryptogenic fibrosing alveolitis ranged from 0.74 to 1.28/100,000. The trend of incidence was increasing slightly. The prevalence rose from 6.5 to 12.1/100,000. The male/female ratio was 1:1.2; 54% of patients were less than 40 years old. Biopsy (mostly open lung biopsy) supported the diagnosis in 38% of cases. During 1981-1990 years 379 new cases were detected, 488 cases altogether were registered up to 1990. The death rate calculated by incidence and prevalence was 13% and 10% resp. The mean regional incidences varied from 0.34 to 2.69/100,000, regional prevalences varied from 4.1 to 27.6/100,000. No correlation with the regional incidences of sarcoidosis and tuberculosis was found. No significant differences in coal mining areas with a high occurrence of pneumoconiosis or in areas with developed agriculture were detected. Significantly higher values were found in the regions of the four major diagnostic centres: a mean incidence of 1.58/100,000 and a mean prevalence of 20.8/100,000 (p < 0.05). The results suggest that the level of diagnostic possibilities and efforts dominates over ecological and environmental factors in the detecting of cryptogenic fibrosing alveolitis.
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PMID:Epidemiology of cryptogenic fibrosing alveolitis in Moravia and Silesia. 777 6

Standard epidemiological and clinical features of sarcoidosis were evaluated in 24 regional centres from Moravia and Silesia (4 million inhabitants). During 1981-1990 the incidence ranged from 3.3 to 4.4/100,000 with slight decrease after 1985, when unselected chest X-ray screening was restricted. The prevalence (however disputable in sarcoidosis) increased from 41.3 to 63.1/100,000. Sex ratio male/female was 1: 2.35; only 39% of patients were younger than 40 years. Biopsy supported the diagnosis in 60% of cases. Tuberculin negativity was found in 64%. X-ray types were presented as follows: 0-2%, I-71%, II-22%, III-5%. Regional incidences varied from 0.9 to 11.7/100,000. Lower values were found in mining areas and high pneumoconiosis incidence. The course of the disease was benign with only sporadic extrapulmonary complications or pulmonary fibrosis. The results indicate that improved knowledge of sarcoidosis has brought epidemiological equilibrium to the evaluated area.
Sarcoidosis 1994 Sep
PMID:Epidemiological study on sarcoidosis in Moravia and Silesia. 780 93


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