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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Silicosis, which acquired great significance during the period of increase in mining and construction, continues to be a pathology with a high morbidity and mortality within pneumoconiosis. Exposure to silica produces pathological, clinical and radiological alterations that together with compatible personal antecedents suggests its diagnosis in a simple way. The associated complications as well as its differential diagnosis from other types of pneumopathy mean that a review of this entity is needed.
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PMID:[Silicosis]. 1591 75

Government regulation of dangerous trades and the compensation of those injured by their work remains a matter of considerable debate among medical historians. Trade unions have frequently been criticized for pursuing financial awards for their members rather than demanding improvements in health and safety at the workplace. This article examines the neglected subject of silicosis injuries in Britain from the time when the first legislation was passed for compensation of those suffering from the harmful affects of silica dust in 1918 to the outbreak of war in 1939, when a major new study was under way which would transform the scientific understanding and the legal compensation of those who were diagnosed as being ill with pneumoconiosis. It is argued that in framing legislation from compensation, politicians and their civil servants sought to retain the legal framework created in 1897-1906 and developed a model of industrial insurance which depended to a large extent on a co-operative relationship with leading employers. Medical scientists identified silica as a uniquely hazardous agent in workers' lung disease, which emphasizing the specialist knowledge required for its diagnosis. One remarkable feature of the selective compensation schemes devised after 1918 was the reliance on geological rather than pathological evidence to prove compensation rights as well as strict employment limits on those eligible to claim. only the campaigning of labour organizations and persistent evidence of lung disease among anthracite coal miners led to a significant relaxation of compensation rules in 1934 and the fresh scientific investigation which transformed the medical understanding of respiratory illness among industrial workers.
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PMID:Coming up for air: experts, employers, and workers in campaigns to compensate silicosis sufferers in Britain, 1918-1939. 1598 83

This study is aimed to evaluate the incidence of silicosis and the relation of it with personal and work-related factors among workers exposed to silica in ceramic factory. Workers were evaluated by respiratory symptoms, physical examination, pulmonary function and radiological findings. Occupational and Enviromental Pulmonary Disease Evaluation Questionnaire of the Turkish Thoracic Society Enviromental and Occupational Pulmonary Diseases Working Group was used. 365 of 626 workers had exposure to silica and the rest 261 were concerned as control group. There was no difference between mean age, duration of work and smoking pack year among the groups (p> 0.05). Cough and sputum rates were higher in silicosis group FEV1 and FVC values were lower in silica group but this was not statistically significant. When the two subgroups of silica group (the workers in high dust concentration and the ones in low concentration) were compared, the high concentrated group had significantly more sputum but the other symptoms and pulmonary functional parameters were not different significantly. 24 workers had parenchymal densities adjusted with pneumoconiosis. The workers with the pneumoconistic finding, had a higher mean age and longer duration of work. As a conclusion, ceramic industry has risk for silicosis. And the risk increase by time and age.
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PMID:[Evaluation of silicosis in ceramic workers]. 1610 Jun 51

Surgical strategy for patients for lung cancer with coronary disease remains controversial. We performed concomitant off-pump coronary artery bypass grafting (off-pump CABG: OPCAB) and left lower lobectomy with ND 2a lymph nodes dissection for lung cancer with pneumoconiosis. After CABG, due to fixed adhesion of peribronchial lymph node, left lower lobectomy was hard to carry out. Postoperative management was done with much difficulty for massive sputum and pneumonia caused by chronic inflammatory lung disease. As a result, postoperative course has been uneventful for 2 years after operation. In the concomitant OPCAB and lung resection with chronic inflammatory lung disease, whether the synchronous or 2 periods operation was appropriate was still unknown. We think that careful pre- and intraoperative assessment for this disease is important.
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PMID:[Concomitant off-pump coronary artery bypass and left lower lobectomy for lung cancer with pneumoconiosis]. 1628 52

It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (IL18 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1 /C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was assessed according to job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-yr change in CT score and CWP incidence and prevalence. CT score in 1990 was a good predictor of radiographic grade in 1999 and, therefore, an appropriate subclinical quantitative trait. The IL18 -137C allele was associated with lower CT score in 1990 and 1994 (1.24 versus 1.69 and 1.57 versus 2.46, respectively), slower progression of CT score between 1990 and 1994 and lower pneumoconiosis prevalence in 1999 relative to the G allele (0.33 versus 0.77 and 8.2 versus 19.6%, respectively). Smoking- or dust-adjustment, and stratification on IL18R1 genotype and adjustment for haplotype effects did not change the conclusions. In conclusion, the results of the present study suggest a role for IL18 in reducing the development of this fibrosing lung disease.
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PMID:IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. 1697 11

Mining production has accounted for around 50% of the gross industrial product in Mongolia since 1998. Dust-induced chronic bronchitis and pneumoconiosis currently account for the largest relative share (67.8%) of occupational diseases in Mongolia, and cases are increasing annually. In 1967-2004, medically diagnosed cases of occupational diseases in Mongolia numbered 7,600. Of these, 5,154 were confirmed cases of dust-induced chronic bronchitis and pneumoconiosis. Lung diseases and other mining-sector health risks pose major challenges for Mongolia. Gold and coal mines, both formal and informal, contribute significantly to economic growth, but the prevalence of occupational lung diseases is high and access to health care is limited. Rapid implementation of an effective national program of silicosis elimination and pneumoconiosis reduction is critical to ensure the health and safety of workers in this important sector of the Mongolian economy.
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PMID:Occupational lung diseases and the mining industry in Mongolia. 1771 77

Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP), which is a chronic inflammatory and fibrotic lung disease. Recently, chronic inflammation has been accepted as a crucial factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and formation of free radicals. Interaction of reactive oxygen species (ROS) with DNA augments the likelihood of DNA structural and transcriptional errors. The purpose of this study was to investigate the genotoxic risk in pneumoconiotic patients and in those with occupational exposure to coal dust. Therefore, sister chromatid exchange (SCE) and micronucleus (MN) tests were performed in Turkish CWP patients, coal workers, and an unexposed control group. Both SCE and MN frequencies in CWP patients were found significantly higher than in coal worker and unexposed groups. There were no differences between SCE and MN frequencies of coal worker and unexposed groups. On the other hand, no correlation between SCE frequency, duration of exposure, and age was observed in all three groups. There was also no effect of smoking on the frequencies of SCE and MN in the groups. Based on these results, it might be suggested that development of CWP leads to a significant induction of cytogenetic damage in peripheral lymphocytes of CWP patients. This is the first report on CWP patients with elevated cytogenetic endpoints. Further, a larger follow-up study is warranted.
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PMID:Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey. 1828 20

Pulmonary disease due to talc, a group of hydrous magnesium silicates, is almost exclusively encountered secondary to occupational exposure or intravenous drug abuse. Talcosis or talc pneumoconiosis is one of the rarer forms of silicate-induced lung disease. It is seen in workers exposed during its production, and occasionally, in users of cosmetic talc and in intravenous drug addicts. Very often, the history of exposure is not recognised by the patient, and it is only the finding of granulomatous cellular interstitial lesions containing birefringent crystals which indicates considerable talc exposure. We report a 38-year-old woman who was initially diagnosed with sarcoidosis, until a bronchoscopic biopsy revealed the presence of numerous foreign body giant cells and birefringent particles forming non-caseating granulomas. There was no history of occupational exposure to talc or intravenous drug abuse. The patient responded to oral corticosteroid treatment. Talcosis is generally considered to be relatively benign.
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PMID:Talc granulomatosis mimicking sarcoidosis. 1869 49

An association between Mycobacterium malmoense and underlying lung disease has been described. The purpose of this study was to further explore this relationship and in particular to identify any relationship between Coal Workers' Pneumoconiosis (CWP) and M. malmoense infection. Patient charts were reviewed of all patients who had a positive sputum or bronchoalveolar lavage for M. malmoense from 1999 to 2006 in a large district general hospital in South Yorkshire, UK. We also performed a literature review in search of this association; one case report was found. Four patients had positive sputum cultures for M. malmoense but only three of these fulfilled the ATS 1997 criteria for diagnosis of disease. Of these three patients, all had clinical and radiologic evidence of CWP. This study strengthens the evidence of a link between nontuberculous mycobacteria and underlying lung disease but more importantly highlights an association between M. malmoense and CWP which has been rarely reported and is poorly understood.
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PMID:An association between Mycobacterium malmoense and coal workers' pneumoconiosis. 1875 57

Estimating the burden of exposure-related diffuse lung disease in terms of health effects and economic burden remains challenging. Labor statistics are inadequate to define the scope of the problem, and few studies have analyzed the prevalence of exposure-related illnesses and the subsequent health care cost. Well-defined exposures, such as those associated with coal mines, asbestos mines, and stonecutting, have led to more accurate assessment of prevalence and cost. As governmental regulation of workplace exposure has increased, the prevalence of diseases such as silicosis and coal workers' pneumoconiosis has diminished. However, the health and economic effects of diseases with long latency periods, such as asbestosis and mesothelioma, continue to increase in the short term. Newer exposures, such as those related to air pollution, nylon flock, and the World Trade Center collapse, have added to these costs. As a result, estimates of cost for occupational diseases, including respiratory illnesses, exceed $26 billion annually, and the true economic burden is likely much higher.
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PMID:The burden of exposure-related diffuse lung disease. 1922 57


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