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Query: UMLS:C0032273 (pneumoconiosis)
 1,578 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-two cases (20.13%) of primary lung cancer from 159 coal miner autopsies of Beijing coal mining area are reported in this study. The ratio of peripheral type to central type of lung cancer is 1.9:1; among them the adenocarcinoma is the most frequent (56.25%). Pathological examination shows that the diffuse interstitial type is the most common lung cancer. The occurrence of adenocarcinoma and the degree of lung fibrosis is related. The average number of ferruginous bodies is 190.2 +/- 8.06 in adenocarcinoma, 165.4 +/- 2.60 in squamous carcinoma, the difference is statistically significant (P < 0.05). The amount of trace elements-Fe, Al, Al/Si and Zn/Cu in lung with cancer is less than that without cancer. This article also discusses the relationship between coal mine pneumoconiosis with lung cancer of the formation of ferruginous bodies in the lung tissue of coal miner autopsies, which resembles the lung cancer combined with asbestosis. We also discussed the carcinogenesis of trace element in lung.
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PMID:[Study on the incidence of coal mine pneumoconiosis and lung cancer in Beijing coal mining district]. 129 8

Pathological studies on lung carcinoma associated with pneumoconiosis were made in order to clarify the etiological significance of pneumoconiosis in carcinoma of the lung. Between 1960 and 1986, the author evaluated approximately 450 autopsies of pneumoconiosis. Of these, 150 were consecutive autopsies in our over laboratory and the remaining 300 were kindly provided by other hospitals. Carcinoma of the lung was seen in 48 of the autopsies. Pathological studies determine histologic type, cancer site, and severity of pneumoconiosis were performed in the 48 cases. The severity of pneumoconiosis was determined by the extent of progressive massive fibrosis (PMF). Simple pneumoconiosis was classified as mild, pneumoconiosis with PMF smaller than segmental region as moderate and pneumoconiosis with PMF larger than lung segment as severe. Carcinoma of the lung was seen in 25 of our own consecutive autopsies, an incidence of 17.9%. The incidence of lung carcinoma was high among cases of mild pneumoconiosis and low among cases of severe pneumoconiosis. Overall, the predominant cancer was squamous cell carcinoma (54.2%) followed by small-cell carcinoma (22.9%) and adenocarcinoma (14.6%). There was a clear trend that most of the squamous cell carcinomas were found in the larger airways, whereas the adenocarcinoma was found only in the peripheral lung tissues. In cases of mild pneumoconiosis, the majority of tumors arose in the right, upper and larger airways. On the other hand, in cases of moderate and severe pneumoconiosis, more tumors arose in the left, lower and peripheral lung areas.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A pathological study of carcinoma of the lung and pneumoconiosis]. 255 27

In September, 1980, a 57-year-old male, was admitted to hospital for precise examinations to determine if he had Recklinghausen's disease, pneumoconiosis, and a duodenal ulcer. Endoscopy revealed a redness and a shallow depression of the posterior wall of the antrum, and a biopsy of a specimen led to the diagnosis of early gastric cancer, Stage II c. After the examination, the patient did not return to our department again. In May, 1987, however, the man was readmitted to our hospital, suffering from pains in the right back. X-ray and endoscopic findings revealed a gastric cancer with a center depression and a peripheral elevation (II a + II c). Histological findings showed the gastric cancer to be a moderately differentiated tubular adenocarcinoma, with a submucosal invasion that was also seen. This case, uncovered 80 months earlier, represents a rare instance in which an early gastric cancer, accompanied by Recklinghausen's disease, expanded slowly.
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PMID:[A case of early gastric cancer accompanied by Recklinghausen's disease]. 314 57

One hundred and fifty five male cases of asbestosis certified by the London Pneumoconiosis Medical Panel during 1968-74 were followed up during 1978-9, 4-11 (mean 7.5) years after certification. Fifty nine patients had died, 23 (39%) from lung cancer, 6 (10%) from mesothelioma, and 11 (19%) from other respiratory causes. The number of observed deaths was 2.25 times greater than expected and 7.4 times greater than expected for lung cancer. Adenocarcinoma was the commonest histological type but other cell types were also increased. Finger clubbing (p less than 0.01) and percentage of predicted FEV1 (p less than 0.01) were of value in predicting death, but increasing profusion of small opacities greater than 1/0 (ILO/U-C international classification of radiographs of pneumoconiosis, 1971), duration of exposure to asbestos, time from first exposure to asbestos, and percentage of predicted vital capacity and transfer factor did not predict death.
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PMID:Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel. 343 33

A case of titanium dioxide pneumoconiosis accompanied by lung cancer is reported. The patient was a fifty-three-year-old male, who was engaged in packing titanium dioxide for about thirteen years. At autopsy, a papillary adenocarcinoma was located in the right lung. Titanium was diffusely deposited in the lung and was engulfed by macrophages in the interstitium and alveolar spaces. Slight fibrosis of the interstitium around bronchioles and vessels was noticed as an effect of titanium deposition.
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PMID:Titanium dioxide deposition and adenocarcinoma of the lung. 373 12

Generally, it is reported that the smallest tumor that can be detected with the 67Ga scintigram is limited to a diameter of approximately 3.0 cm. To surmount that limitation we have attempted to detect small lung cancer by means of quantitative external counting of 67Ga uptake rather than the qualitative scintigram. Seventy-two hours after 67Ga injection, the uptake counts of tumor (T) and a corresponding normal region in the opposite lung (N) were measured with scintillation camera. The 67Ga uptake ratio ((T-N)/N) could then be calculated. The 67Ga uptake ratio of 6 pulmonary adenocarcinomas was measured to be 0.05-0.22. In contrast, the 67Ga uptake ratio of benign lesions such as tuberculoma, pulmonary infarct, cyst, pneumoconiosis, mucoid impaction, hamartoma and chronic inflammatory lesion with calcification resulted in negative values (-0.01--0.77). From these results, it was possible to differentiated small adenocarcinoma of the lung tumor from these benign diseases. However, the 67Ga uptake ratios of 4 cases of active tuberculosis, 5 chronic inflammatory lesions and 1 granuloma were 0.01-0.41. The cases with more than 0.30 of 67Ga uptake ratios all represented active inflammatory lesions. However, there were some cases of inflammatory lesions where the values overlapped with adenocarcinoma.
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PMID:[Detection of small pulmonary carcinoma by 67Ga uptake ratio]. 657 9

A 60-year-old man has been followed up for pneumoconiosis for 7 years. He was admitted to our hospital because of melena. He was undergone a colonofiberscopy and was diagnosed as rectal cancer. We performed anterior resection of the rectum (Stage I). About 5 months after the first operation, abnormal shadows of the both lungs were growing in size. Bronchoscopic examination revealed adenocarcinoma, we performed left upper lobectomy (Stage I) and this case was judged a synchronous double cancer.
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PMID:[Experience with surgery for synchronous double cancer of rectum and lung detected after long-term follow-up for pneumoconiosis]. 895 94

Mutations of suppressor gene p53 was studied in 36 cases of silica related lung cancer and 6 cases of welding fume related lung cancer with immunohistochemical and PCR-SSCP methods. Cancer tissues were embedded in paraffin and stored for 13.4 years in average. Results revealed that there was abnormal mobility shift of electrophoresis in 18 cases with 20 point mutations of 42 specimens tested, accounted for 42.9%, and 50% (10/20) of the mutations were clustered in exon 8. This finding differed from mutational spectrum of gene in non-occupational lung cancer, in which mutation frequency of exon 8 ranged from 17.5% to 23.5%. Gene mutation frequency in varied pathological categories of pneumoconiosis related lung cancer also differed from that in common lung cancer. In the latter, the highest one was in small cell lung cancer (70%) and the lowest in adenocarcinoma (33%), but in the former, the highest in adenocarcinoma (53.9%) and the lowest in small cell lung cancer (30.8%). Immunohistochemical observations also showed a very high prevalence of p53 gene mutation expression (46.9%). Sequencing, which was determined in two cases of this study, revealed that two point mutations all occurred in non-hotspot codon 144 of p53 gene. Difference in gene mutation spectrum suggests that there exist specific carcinogens and carcinogenesis in silica and welding fume related lung cancer.
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PMID:[A preliminary study on p53 gene in lung cancer tissues of workers exposed to silica and welding fumes]. 981 93

A 70-year-old man who had worked in a stonepit for about fifty years was admitted to our hospital for detailed examination of the signs of pneumoconiosis (3/3, q) and a nodular shadow in the right upper lung field. Under a clinical diagnosis of lung cancer complicated with pneumoconiosis, right upper lobectomy with a right S6 resection was performed. Pathological examination revealed moderately differentiated adenocarcinoma of the right S2, well-differentiated adenocarcinoma of the right S6, and a squamous cell carcinoma of the right S1 which was not detected by chest CT. In addition to the difficulty of diagnosing lung cancer in a patient with severe pneumoconiosis, treatment for lung cancer may be limited by the poor pulmonary function that results from pneumoconiosis. Although the labor administration's decision that lung cancer patients with concomitant pneumoconiosis deserve compensation can be evaluated as a good one, the study of the relationship between pneumoconiosis and lung cancer needs further study through follow-up examination of pneumoconiosis cases.
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PMID:[A case of severe pneumoconiosis with synchronous triple lung cancer]. 1293 79

A 79-year-old man, who had an occupational history of handling rushes (which were treated with pigmented earth containing 25% silica) for 30 years and a past history, eight years earlier, of primary pulmonary adenocarcinoma in the left lower lung (T2N2M0), was admitted to our hospital for the investigation of two nodular shadows in the right upper S3 which showed a double lesion detected on chest CT. A histological diagnosis of pulmonary adenocarcinoma was obtained by bronchoscopic examination, and so he was transferred to the Department of Thoracic Surgery and video-assisted thoracoscopic surgery (VATS) was performed. Subsequently, the large part of the tumor, in the central region, was diagnosed as a pulmonary adenocarcinoma, and the smaller part of the tumor, in the peripheral region, was found to consist of an adhesion of small nodules composed of pneumoconiosis due to the rushes. Multiple small nodules consisting of rush pneumoconiosis were histologically recognized surrounding this smaller part of the tumor. Although, at admission, we first suspected the presence of multicentric, metastatic lung cancer and an inflammatory tumor, the patient's occupational history also proved to be important, and we could not decide on the appropriate diagnosis before VATS because multiple small nodules consisting of rush pneumoconiosis overlapped the tumor.
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PMID:[A case of pulmonary adenocarcinoma coexistent with Igusa pneumoconiosis in one segment of the lung]. 1522 44


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