Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0031511 (pheochromocytoma)
 14,622 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma immunoreactive endothelin-1 (ET-1) concentrations were measured in 44 patients with pheochromocytoma, 31 patients with essential hypertension, and 20 healthy control subjects. Plasma ET-1 concentrations in patients with pheochromocytoma were 18.2 +/- 3.2 fmol/mL (mean +/- SEM), which was significantly higher than those of essential hypertension and healthy control subjects (7.3 +/- 0.4, 7.1 +/- 0.4 fmol/mL, respectively, P < .01). Plasma ET-1 concentrations in patients with essential hypertension and control subjects were similar. In patients with pheochromocytoma, hypertensive group had higher ET-1 than normotensive group (23.0 +/- 5.5 v 12.4 +/- 2.2 fmol/mL), but the difference was not significant. In 17 patients with pheochromocytoma, the elevated plasma ET-1 concentrations (17.4 +/- 4.7 fmol/mL) returned to normal levels (7.9 +/- 0.6 fmol/mL, P < .05) after surgical resection of the tumor. ET-1 contents in the 26 tumor tissues (1.40 +/- 0.29 pmol/g) were higher than those in 7 normal adrenal medullas (0.44 +/- 0.12 pmol/g). Systolic, diastolic, and mean blood pressures were better correlated with plasma norepinephrine than ET-1 in patients with pheochromocytoma. These data indicate that pheochromocytoma might produce and secrete excessive amounts of ET-1. The hypertension in patients with pheochromocytoma is mainly catecholamine-dependent, but may be secondarily ET-1-dependent.
 ...
PMID:Elevated immunoreactive endothelin levels in patients with pheochromocytoma. 798 62

The erythrocyte Na+/Li(+)-countertransport activity was studied in patients with essential hypertension (n = 59), chronic glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 35) and pheochromocytoma (n = 3). The erythrocyte Na+/Li(+)-countertransport (SLC) activity was on average higher (p < 0.02) in the patients with essential hypertension as compared to those with secondary hypertension, although a clear distinction between both groups was not possible. After surgical treatment of the patients with atherosclerotic renal artery stenosis, fibromuscular dysplasia or pheochromocytoma, no change in erythrocyte SLC activity was observed. However, blood pressure was significantly reduced.
 ...
PMID:Red blood cell sodium-lithium countertransport in patients with essential and renal hypertension. 800 44

We studied 5-mg metoclopramide provocation in six pheochromocytomatous patients with different tumor locations, varying secretory patterns and large tumor sizes (> 12 g or equivalently) and in 14 patients with essential hypertension as part of diagnostic work-up, usually after screening with vanillylmandelic acid assay by the colorimetric method. Antihypertensive medication continued in three and five patients, respectively. Despite similar basal blood pressures patients with pheochromocytomas developed more prominent pressor responses in five of six patients than the nonpheochromocytomatous patients (P < 0.01), most (10) of the latter with negligible pressor responses. Basal plasma catecholamines were higher in each of the pheochromocytomatous patients of different secretory patterns. Further rises after provocation were seen in all pheochromocytomatous patients except one with early pressor response, and also in one nonpheochromocytomatous patient. All tests were well tolerated. Thus, we concluded that the metoclopramide test based upon joint pressor response and plasma catecholamine response can be safely used in the diagnosis of pheochromocytoma. A less stringent protocol including a short drug-off preparatory period may be a warranted compromise between feasibility and diagnostic accuracy.
 ...
PMID:Diagnostic use of metoclopramide in hypertension caused by pheochromocytoma. 811 9

It was reported recently that the endogenous digitalis-like factor ouabain may mainly originate from the adrenal gland. To ascertain the pathophysiological significance of endogenous ouabain and to examine if it originates in the adrenal gland, we determined plasma immunoreactive ouabain levels in patients with various cardiovascular and endocrine diseases. Plasma immunoreactive ouabain levels were also determined in the adrenal venous blood by adrenal venous sampling. Plasma immunoreactive ouabain levels were significantly increased in patients with essential hypertension, primary aldosteronism, Cushing's syndrome, pheochromocytoma, acromegaly, and chronic renal failure. Plasma immunoreactive ouabain levels were decreased in patients with primary aldosteronism after unilateral adrenalectomy, acromegaly after pituitary adenomectomy, and chronic renal failure after hemodialysis. Plasma immunoreactive ouabain levels in patients after bilateral adrenalectomy were similar to those in healthy subjects. There was no significant step-up of immunoreactive ouabain levels in the adrenal vein from the peripheral vein in three patients, whereas one patient with hypertension and right adrenal tumor but without any known adrenal hormone excess showed higher plasma immunoreactive ouabain levels in the right adrenal vein than those in the peripheral vein. These results suggest an important pathophysiological significance of endogenous ouabain in various cardiovascular and endocrine diseases. It is unlikely that the adrenal gland is a major source of plasma ouabain, although a possible excess production of ouabain by the adrenal tumor remains to be elucidated.
 ...
PMID:Does plasma immunoreactive ouabain originate from the adrenal gland? 828 39

Endocrine Hypertension, is, in a narrow sense, defined as adrenal hypertension, including mainly pheochromocytoma, Cushing's syndrome, a syndrome of primary aldosteronism and it's related mineralocorticoid excess disorders. In memory of a great contribution to hypertensiology by the late Prof. Murakami, who was the first author to write on pheochromocytoma in Japan, this paper is dedicated to reviewing the current status of adrenal hypertension in Japan from the epidemiological viewpoint, putting emphasis upon the clinical characteristics of aged patients with adrenal hypertension. Secondly, some topics in the research field of each adrenal hypertension are briefly introduced. Thirdly, our recent data are presented, showing 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) mRNA expression in resistance vessels and decreased 11 beta-HSD activities in vessels in SHR which supports the hypothesis that there might exist a subtype identified as partial impairment of 11 beta-HSD in patients with essential hypertension.
 ...
PMID:[Endocrine hypertension]. 833 19

A case of a 43-year-old woman with severe sustained hypertension resistant to many antihypertensive drugs, frequent hypertensive crisis and symptoms suggestive of pheochromocytoma (symptomatic triad) is presented. Three of the four determinations of the urinary catecholamines metabolites have been normal as it was the only determination of plasmatic catecholamines. Abdominal sonography and CT scan detected a left adrenal mass, that have been histologically confirmed, after surgery, to be a pheochromocytoma. After adrenalectomy, the patient symptoms disappeared but she maintained mild hypertension easily controlled with drugs. The finding of normal plasmatic and urinary catecholamines values in a patient with sustained hypertension may suggest that we are handling with a case of essential hypertension and a superimposed pheochromocytoma with paroxysmal secretion. Some considerations are made essentially about specificity and sensitivity of diagnostic tests.
 ...
PMID:[Pheochromocytoma--apropos a clinical case]. 835 84

131I-MIBG scintigraphy was performed on 18 patients with pheochromocytoma and 25 patients with essential hypertension. In comparison of grade of 131I-MIBG accumulation in various organs the heart accumulation of pheochromocytoma group was significantly lower than that of essential hypertension group. And between the positive and false negative accumulation group of pheochromocytoma reverse relationship was observed between the heart and tumor. The results of 131I-MIBG scintigraphy for pheochromocytoma included 78% sensitivity, 100% specificity, and 90% accuracy. False negative accumulation of tumors were shown at 6 lesions in 4 cases. On the bases of CT and operative findings, false negative accumulation was observed not only in very small tumors, but also in large cystic tumors with a small amount of tumor tissue or totally hemorrhagic necrosis within the tumor.
 ...
PMID:[Diagnosis of pheochromocytoma using 131I-MIBG scintigraphy]. 847 92

Dopamine (DA) is the most abundant catecholamines in human plasma and exists mostly in the sulfo-conjugated form (DA sulfate), a biologically inactive metabolite. The paucity of unconjugated DA (PDA) in plasma throws doubt on its physiological significance. However, PDA, when measured with a highly sensitive radioenzymatic method, showed quite different features from norepinephrine and epinephrine in some types of clinical hypertension, lower in essential hypertension and higher in primary aldosteronism and pheochromocytoma. There was a weak but significant correlation between the values of PDA and DA sulfate measured in the same specimens, but DA sulfate was more susceptible to impaired renal function. Upright posture, high salt diets and an intravenous injection of metoclopramide (MCP, 10 mg), a DA receptor antagonist, induced a slight but significant increase in PDA in normal and hypertensive subjects. An intravenous dexamethasone (2 mg) caused a gradual increase in PDA over 150 min after medication, which was completely blocked by concomitant administration of alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor. The responses of PDA to both high salt diets and MCP were blunted in salt-sensitive patients with uncomplicated essential hypertension. The results suggest that DA is not only a precursor of norepinephrine biosynthesis but also plays an inherent role as an active neurotransmitter in the peripheral sympathoadrenal system, and that PDA is a sensitive marker of peripheral dopaminergic activity, which may operate to modulate the cardiovascular and endocrine functions and participate in the pathogenesis of some types of hypertension.
 ...
PMID:Plasma free dopamine: physiological variability and pathophysiological significance. 852 77

Adrenomedullin is a novel hypotensive peptide recently discovered in human pheochromocytoma. In the present study, we measured the plasma immunoreactive adrenomedullin of healthy subjects and patients with various diseases. Immunoreactive adrenomedullin was found to circulate in blood of the healthy subjects at a considerable concentration (3.3 +/- 0.3 fmol/ml). Plasma adrenomedullin was significantly increased in the patients with congestive heart failure (5.4 +/- 0.3 fmol/ml), essential hypertension (5.3 +/- 0.4 fmol/ml) and renal disease (4.9 +/- 0.4 fmol/ml). In healthy volunteers physical exercise significantly increased the plasma adrenomedullin concentration. The increase of adrenomedullin was inversely related to systolic blood pressure. These findings indicate that adrenomedullin participates in the circulation control in both physiological and diseased conditions. Although the exact origin of circulating adrenomedullin is still unknown, it is thought to be released rapidly by acute exercise, thereby regulating the cardiovascular system by its vasodilating activity.
 ...
PMID:Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects. 856 10

The aim of the study was to evaluate possible changes of plasma endothelin-1 levels (ET-1) in patients with hypertension secondary to primary aldosteronism and pheochromocytoma. We enrolled in the study: 12 patients affected by aldosterone-producing adenoma (5 M and 7 W; mean age 42.1 +/- 17.2 years); 8 patients with pheochromocytoma (5 M, 3 W; mean age 36.2 +/- 17.1 years); 15 patients with essential hypertension (9 M, 6 W; mean age 48.5 +/- 10 years). We also enrolled a normal control group (8 M, 12 W; mean age 34.2 +/- 11 years). The mean plasma ET-1 concentrations in patients with pheochromocytoma were significantly higher (23.9 +/- 5.2 pg/ml) than those in normal subjects (7.3 +/- 1.9 pg/ml), in patients with primary aldosteronism (12.1 +/- 3.8 pg/ml) and in patients with essential hypertension (9.2 +/- 3 pg/ml); p < 0.001, respectively. The present investigation demonstrates that in human adrenal hypertension patients with pheochromocytoma have increased circulating ET-1 levels respect to patients with aldosterone-producing adenoma.
 ...
PMID:Plasma endothelin-1 levels in patients with aldosterone-producing adenoma and pheochromocytoma. 888 76


<< Previous 1 2 3 4 5 6 7 8 9 10