Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031511 (pheochromocytoma)
 14,622 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A hypertensive young woman was referred for renal artery angioplasty with the radiographic finding of a right renal artery stenosis and elevated right renal vein plasma renin activity. A repeat preangioplasty arteriogram, obtained six weeks after the institution of antihypertensive therapy that included a vasodilator, demonstrated a diminished right renal artery stenosis and showed a right adrenal pheochromocytoma that was removed surgically. After surgery both the right renal artery caliber and the blood pressure returned to normal. Knowledge of this unusual association between pheochromocytoma and renovascular hypertension could prevent ineffective and unnecessary renal artery angioplasty and/or surgery.
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PMID:Transient renal artery stenosis produced by a pheochromocytoma. 711 22

An unusual case of pheochromocytoma associated with multifocal medial fibromuscular dysplasia of the left subclavian (ruptured), celiac, and bilateral renal arteries is described. Additionally, the coronary arteries, left renal arcuate vessels, and peripancreatic and intracolonic muscular arteries revealed intimal fibroplasia. Thirty-three cases of pheochromocytoma associated with renal artery stenosis have been reported, including four instances radiologically attributed to fibromuscular dysplasia. Renal artery fibromuscular dysplasia associated with pheochromocytoma has not been histologically documented, and extrarenal fibromuscular dysplasia with simultaneous pheochromocytoma has not been previously described. Current etiologic concepts of fibromuscular dysplasia and possible pathogenetic mechanisms for its occurrence with pheochromocytoma are discussed.
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PMID:Pheochromocytoma associated with arterial fibromuscular dysplasia. 723 61

A rare case of intrarenal pheochromocytoma associated with a renal artery stenosis is reported. The association between pheochromocytoma and renal artery stenosis is discussed.
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PMID:Intrarenal pheochromocytoma and renal artery stenosis. 731 23

We present a new case of pheochromocytoma and renal artery stenosis making remark about the haemodynamic role of the last and the effects tha presence of the tumor may have on blood flow changes through the stenosis. Finally, the suggestion is made that in these cases where two causal factors are found, both surgical treatments should be carried out in the same operating time.
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PMID:Pheochromocytoma and renal artery stenosis. 746 11

Liddle's syndrome, a rare cause of hypokalemic hypertension, is characterized by a renal tubular sodium channel defect resulting in excessive sodium absorption and concomitant potassium wasting. In this disorder, although the clinical manifestations resemble primary aldosteronism, serum and urine aldosterone are suppressed. The syndrome is transmitted in an autosomal dominant pattern. It has been reported previously in white and oriental populations but not in the black individuals. We identified four patients (two of whom are black) in our nephrology clinic, with severe hypokalemic hypertension not correctly diagnosed for several years. All patients underwent an extensive work-up for secondary hypertension because of persistent severe hypertension (average blood pressure, 210/130 mm Hg) despite high-dose multi-drug therapy. Primary aldosteronism was excluded because of low serum aldosterone. Cushing's syndrome, pheochromocytoma, renal artery stenosis, and enzymatic deficiencies of cortisol synthesis (11 beta-hydroxylase, 17 alpha-hydroxylase, 5 beta-reductase, and 11 beta-hydroxysteroid dehydrogenase) were ruled out with extensive endocrine and radiologic studies. Once the diagnosis of Liddle's syndrome was suspected, all patients were treated with either triamterene or ameloride, with resolution of hypokalemia and correction of hypertension occurring within 5 to 7 days. Our findings suggest that Liddle's syndrome can occur in the black population. Although the actual incidence of this syndrome remains unknown, it may be significantly more common than we are led to believe since it is inherited in a Mendelian pattern. Whether there is a subset of low-renin, salt-sensitive black hypertensive patients who have the same or similar sodium channel defect remains to be elucidated.
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PMID:Liddle's syndrome, an underrecognized entity: a report of four cases, including the first report in black individuals. 777 90

The two unusual clinical cases described here illustrate the importance of correct application of clinical methodology. Two patients, a 55-year-old man and a 50-year-old woman, presented with severe hypertension due to the coexistence of renal artery stenosis and pheochromocytoma. Their symptoms were indicative of renovascular hypertension which was verified by the finding of extremely elevated plasma renin activity and angiographic detection of critical renal artery stenosis. Further consideration of specific clinical findings led to the suspicion of coexisting pathologies: the detection of elevated plasma catecholamine levels and abdominal computed tomography and iodobenzylguanidine imaging confirmed the presence of pheochromocytoma. The first patient repeatedly refused surgical treatment and died after 9 months; the second patient recovered after undergoing combined nephrectomy and tumor removal. These cases underscore the importance of a carefully planned sequence of studies in patients presenting with uncommon or equivocal clinical manifestations, particularly when conclusive diagnosis is essential to successful treatment.
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PMID:[Coexistence of renovascular hypertension and pheochromocytoma. Description of 2 clinical cases]. 791 63

The erythrocyte Na+/Li(+)-countertransport activity was studied in patients with essential hypertension (n = 59), chronic glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 35) and pheochromocytoma (n = 3). The erythrocyte Na+/Li(+)-countertransport (SLC) activity was on average higher (p < 0.02) in the patients with essential hypertension as compared to those with secondary hypertension, although a clear distinction between both groups was not possible. After surgical treatment of the patients with atherosclerotic renal artery stenosis, fibromuscular dysplasia or pheochromocytoma, no change in erythrocyte SLC activity was observed. However, blood pressure was significantly reduced.
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PMID:Red blood cell sodium-lithium countertransport in patients with essential and renal hypertension. 800 44

The three most common causes--renal artery stenosis, pheochromocytoma, and primary aldosteronism--are reviewed, including uncomplicated screening procedures to select candidates for a more intensive workup. The first two conditions are usually corrected by angioplasty or surgery, whereas aldosteronism may require both surgical and medical therapy or medication alone.
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PMID:Secondary hypertension: workup and correction. 814 18

"Diagnostica" is a Bayesian statistical tool designed to collect and store the patient's data, suggest a diagnosis, and explain the decision in terms of density distributions. The program is written in C language on MacIntosh support. It is described using the case study of differential diagnosis between essential and secondary hypertensions (i.e., fibrodysplastic renal artery stenosis, atheromatous renal artery stenosis, Conn's syndrome, nephropathy and pheochromocytoma). Seventeen experimental parameters were taken into consideration, all of them available during the first medical examination. The density distributions of all items were established from the ARTEMIS experimental database. Both a priori probabilities of different types of hypertension and loss coefficients are taken into account in the calculations. Diagnostica can be used in a "make diagnosis" mode or in an "edition" mode. In the first case it can serve a physician in everyday practice; in the second it becomes a tool for medical research.
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PMID:Diagnostica--a Bayesian decision-aid system--applied to hypertension diagnosis. 833 26

With the aim to analyze the association of Type I Neurofibromatosis with secondary arterial hypertension, a retrospective study has been performed on 36 patients, diagnosed of pheochromocytoma (n = 12) and/or renal artery stenosis (n = 25), finding in 6 of them diagnostic criteria of Type I neurofibromatosis, of these 4 showed pheochromocytoma, 1 renal artery stenosis and 1 pheochromocytoma plus renal artery stenosis. CAT and angiography were the best diagnostic imaging methods to confirm clinic and biological suspicion of adrenal tumor of renal artery stenosis. It is recommended the systematized study of patients with NF-1 together with their relatives who phenotypically show some illness stigma, or with arterial hypertension resistant to conventional treatment.
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PMID:[Secondary arterial hypertension in type I neurofibromatosis (NF-1). Findings in 6 patients]. 848 62


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