Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031350 (
pharyngitis
)
2,405
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neoplastic natural killer (NK) cells overexpress
Fas ligand
(
FasL
), which may cause damage of Fas-bearing tissues. We report a patient with NK cell leukaemia who developed liver injury after
pharyngitis
. The NK leukaemic cells expressed functional
FasL
. In addition to soluble
FasL
, serum levels of interleukin-6 and interferon-gamma were increased dramatically when liver injury was aggravated. Moreover, hepatocytes expressed Fas and apoptotic hepatocytes were detected in the portal areas. These findings are consistent with the notion that inflammatory cytokines enhance the sensitivity to
FasL
and trigger apoptosis of hepatocytes in NK cell malignancies.
...
PMID:Fas ligand-induced apoptosis of hepatocytes in natural killer cell leukaemia. 1046 61
