Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031350 (pharyngitis)
 2,405 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the cohort retrospective study was to analyze and evaluate the influence of certain factors (age, profession, smoking) on the characteristics and the incidence rate of the upper respiratory tract diseases (URTDs) in the occupational contact with ammonium. Subjects were 180 men, divided into 3 professional groups. The average shift concentrations of ammonium were measured in the permanent work places and individually by personal passive dosemeters. The URTDs were classified into 15 groups according to localization and the stage of the inflammatory process. The relationships "time-response" and "dose (concentration)-response" were determined. The factor "cumulative exposure" was used in order to evaluate the actual noxious effect of NH3 on the mucose of the upper respiratory tract (URT). There was a statistically reliable difference found in the incidence rate of atrophic rhinitis, hypertrophic pharyngitis and laryngitis, and neoplasms of the URT in the workers with the highest cumulative exposure. For this group relative risk was 4.00, 2.22, 3.20 and 4.00, respectively, with 95% Cl. The "cumulative exposure" factor gives the best proofs for the toxic effect of ammonium and a possibility for assessment of the relative risk.
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PMID:Risk assessment of the occupational contact with ammonium. 1076 20

Chemical burns are associated with significant morbidity, especially anhydrous ammonia burns. Anhydrous ammonia is a colorless, pungent gas that is stored and transported under pressure in liquid form. A 28 year-old patient suffered 45% total body surface area of second and third degree burns as well as inhalational injury from an anhydrous ammonia explosion. Along with fluid resuscitation, the patient's body was scrubbed every 6 h with sterile water for the first 48 h to decrease the skin pH from 10 to 6-8. He subsequently underwent a total of seven wound debridements; initially with allograft and then autograft. On post burn day 45, he was discharged. The injuries associated with anhydrous ammonia burns are specific to the effects of ammonium hydroxide. Severity of symptoms and tissue damage produced is directly related to the concentration of hydroxyl ions. Liquefactive necrosis results in superficial to full-thickness tissue loss. The affinity of anhydrous ammonia and its byproducts for mucous membranes can result in hemoptysis, pharyngitis, pulmonary edema, and bronchiectasis. Ocular sequelae include iritis, glaucoma, cataracts, and retinal atrophy. The desirability of treating anhydrous ammonia burns immediately cannot be overemphasized. Clothing must be removed quickly, and irrigation with water initiated at the scene and continued for the first 24 h. Resuscitative measures should be started as well as early debridement of nonviable skin. Patients with significant facial or pharyngeal burns should be intubated, and the eyes irrigated until a conjunctivae sac pH below 8.5 is achieved. Although health care professionals need to be prepared to treat chemical burns, educating the public, especially those workers in the agricultural and industrial setting, should be the first line of prevention.
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PMID:Anhydrous ammonia burns case report and review of the literature. 1081 76