Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031350 (pharyngitis)
 2,405 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Group C streptococci are flora members of skin, nasopharynx, gastrointestinal and genitourinary systems. They are rare causes of human pharyngitis, arthritis, pneumonia, meningitis and bacteremia. In this report, a 71-years old male patient with Streptococcus equisimilis arthritis/prosthetic joint infection has been presented. The patient was admitted to the emergency service with the complaints of erythema, swelling and tenderness on right knee which had total knee prosthesis. Examination of synovial fluid punction sample yielded abundant amount of leukocytes (> 1000 cells/mm3). Empirical ampicillin-sulbactam (1 g q6h, parenterally) therapy was initiated. Bacteria which have been cultivated from synovial fluid specimen were identified as S. equisimilis. The isolate was found to be susceptible to penicilin, erythromycin and teicoplanin, and resistant to chloramphenicol and tetracycline. Although clinical presentation improved during the first ten days, symptoms recurred after the 10th day and the therapy was switched to teicoplanin. The recurrence was thought to be the result of antibiotic tolerence. The patient was treated successfully with teicoplanin, and no relapse or reinfection was observed during one year of follow-up. To our knowledge this is the first case of S. equisimilis arthritis reported from Turkey and first case of S. equisimilis associated prosthetic joint infection.
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PMID:[Streptococcus equisimilis associated septic arthritis/prosthetic joint infection]. 1882 98

Infection with non-encapsulated types of Haemophilus influenzae bacteria can cause such diseases as sinusitis, pharyngitis, bronchitis or otitis. Of the six capsulated types of Haemophilus influenzae, type b (Hib) is the main cause of invasive diseases in childhood, including meningitis, septicaemia, epiglottitis, pneumonia, arthritis, osteomyelitis. The article presents the data about the virulence of Haemophilus influenzae, its carrier state, invasive Hib infections in the world and in Poland as well as active prevention with usage of Hib vaccinations, with special reference to high risk groups.
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PMID:[Haemophilus influenzae type b--active prevention]. 1941 41

Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory, gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a series of challenges to successful colonization with which streptococci have to contend. Some species exist in equilibrium with their host, neither stimulating nor submitting to immune defenses mounted against them. Most are either opportunistic or true pathogens responsible for diseases such as pharyngitis, tooth decay, necrotizing fasciitis, infective endocarditis, and meningitis. Part of the success of streptococci as colonizers is attributable to the spectrum of proteins expressed on their surfaces. Adhesins enable interactions with salivary, serum, and extracellular matrix components; host cells; and other microbes. This is the essential first step to colonization, the development of complex communities, and possible invasion of host tissues. The majority of streptococcal adhesins are anchored to the cell wall via a C-terminal LPxTz motif. Other proteins may be surface anchored through N-terminal lipid modifications, while the mechanism of cell wall associations for others remains unclear. Collectively, these surface-bound proteins provide Streptococcus species with a "coat of many colors," enabling multiple intimate contacts and interplays between the bacterial cell and the host. In vitro and in vivo studies have demonstrated direct roles for many streptococcal adhesins as colonization or virulence factors, making them attractive targets for therapeutic and preventive strategies against streptococcal infections. There is, therefore, much focus on applying increasingly advanced molecular techniques to determine the precise structures and functions of these proteins, and their regulatory pathways, so that more targeted approaches can be developed.
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PMID:Streptococcus adherence and colonization. 1972 Oct 85

Of the three studies which have been reported in this paper, the most thorough and therefore the most instructive was that made upon the Rockefeller Institute group of 24 individuals. The ten carriers discovered in this group were found to fall into three categories; namely, chronic, intermittent and transient carriers. It is, perhaps, a matter for surprise, in view of the weight of evidence in the literature, that half of the carriers should appear in the chronic group, being constantly affected for periods over 2 years and continuing to carry throughout this period what was, to all tests, the same strain of microorganism. It has been shown that no claim of relief from the carrier condition can be based on three consecutive negative swabs at weekly intervals since apparent spontaneous "cures," as evidenced by negative swabs, may last for 4(1/2) months and finally be terminated by the reappearance of the same strain as that carried before. The effect of coryza and pharyngitis on the persistence and degree of the meningococcal infection has been studied and, while the results are scanty, indications have been found that coryza, unassociated with any increase in numbers of the nasopharyngeal pathogens or streptococci, causes no change in the number of meningococci present in the throat. On the other hand, a streptococcal pharyngitis or any infection in which other throat pathogens increase greatly in number is usually associated with a marked diminution or actual disappearance, whether temporary or permanent, of the meningococci from the nasopharynx. This is in accordance with the work of Colebrook and Gordon. Of the 26 carrier strains which were isolated in these three groups of individuals, only eight could be identified with Gordon's four types which are isolated from the majority of cases of meningitis. It is considered as certain, however, that the other 18 strains are to be regarded as true meningococci. Not only do they show the same cultural characteristics and fermentative reactions as the typical strains, but serological tests, especially that of absorption, have revealed that they are allied to the two main types, I-III and II, and can be regarded as belonging to the broad serological Groups I and II which include these typical Gordon types. Moreover, atypical Type II* strains, identical with those isolated from the nasopharynx of carriers, have recently been found to be the cause of two cases of frank cerebrospinal fever. Only five of the 26 strains belong to Group I while the other 21 are members of Group II. This is interesting in view of the work of Scott who found that Group II strains predominate in carriers during interepidemic periods like the present. In periods of epidemics the carrier strains from both contacts and noncontacts in the epidemic zone are more often of Group I and even more constantly tend to be of the typical Gordon types rather than atypical forms. As has been pointed out in an earlier paper (35), the viability of these carrier strains when planted in defibrinated rabbit blood is low as compared to the typical and freshly isolated meningitis strains. The exact significance of this fact is not known. It has not been possible up to the present to do comparative virulence tests between spinal fluid and nasopharyngeal strains owing to the absence of a sufficiently susceptible animal.
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PMID:STUDIES ON MENINGOCOCCUS INFECTION : VI. THE CARRIER PROBLEM. 1987 Feb 66

The investigation of this isolated epidemic of meningococcus meningitis at a C.C.C. camp gave an opportunity to examine the carrier state in contacts carrying what were presumably virulent epidemic strains of organisms. With the aid of Miller's technique for the enhancement of the demonstrable virulence of meningococci for mice, it proved possible to test the virulence of the carrier strains from Camp Rusk. These results were consistent despite the interval of from 3 to 4 weeks which intervened between the isolation of the strains and the virulence titrations. Type I strains were found to have a high virulence, while the virulence of Type II strains was moderately high but definitely less than that of the Type I, and atypical strains and strains of N. catarrhalis isolated from carriers showed a very low virulence. The question of the precise nature of the carrier state was investigated. No evidence has been obtained yet as to the existence of a relationship between pharyngitis, coryza or upper respiratory disease and the presence and degree of the carrier state. This is unlike the situation with regard to pneumococcus carriers. On the other hand, it has proved possible to demonstrate reactions within the body to the meningococci in the nasopharynx, consisting of the formation of agglutinins and protective antibodies in the blood serum. 32.3 per cent of Type I and 60 per cent of Type II carrier sera showed moderate or good agglutinins for homologous organisms and 80 per cent of Type I and 40 per cent of Type II sera showed moderate or good protective antibodies against virulent homologous strains. No idea could be obtained as to the relationship of the presence or absence and the degree of serological reaction and the duration of the carrier state.
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PMID:STUDIES ON MENINGOCOCCUS INFECTION : VII. THE STUDY OF AN ISOLATED EPIDEMIC. 1987 Mar 78

Eighty cases of echovirus 18 infection among young children during an outbreak in 2006 in Taiwan were enrolled. Twenty percent of the patients had a comorbid condition. Twenty-five cases (31%) were complicated by aseptic meningitis. The most frequent diagnoses in children without meningitis were pharyngitis/tonsillitis (35%) and vesicular viral exanthem (33%). The case-fatality rate among the children with meningitis was 4%. Echovirus 18 was isolated from the cerebrospinal fluid of 68% of the children.
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PMID:Echovirus 18 meningitis in southern Taiwan. 2088 53

The prolonged use of the antibiotics over the years has transformed many organisms resistant to multiple drugs. This has made the field of drug discovery of vital importance in curing various infections and diseases. The drugs act by binding to a specific target protein of prime importance for the cell's survival. Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes are the few gram positive organisms that have developed resistance to drugs. It causes pneumonia, meningitis, pharyngitis, otitis media, sinusitis, bacteremia, pericarditis, and arthritis infections. The present study was carried out to identify potential drug targets and inhibitors for beta subunit of DNA polymerase III in these three Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. And finally 3D structure of DNA polymerase III subunit beta was modeled. The ligand library was generated from various databases to find the most suitable ligands. All the ligands were docked using Molegro Virtual Docker and the lead molecules were investigated for ADME and toxicity.
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PMID:Subtractive genomics approach to identify putative drug targets and identification of drug-like molecules for beta subunit of DNA polymerase III in Streptococcus species. 2241 82

Yersinia pestis is a highly pathogenic gram-negative bacterium and the causative agent of human plague. In the last 1500 years and during three dreaded pandemics, millions of people became victims of Justinian's plague, the Black Death, or modern plague. Today, Y. pestis is endemic in natural foci of Asian, African and American countries. Due to its broad dissemination in mammal species and fleas, eradication of the pathogen will not be possible in the near future. In fact, plague is currently classified as a "re-emerging disease". Infection may occur after the bite of an infected flea, but also after oral ingestion or inhalation of the pathogen. The clinical presentations comprise the bubonic and pneumonic form, septicemia, rarely pharyngitis, and meningitis. Most human cases can successfully be treated with antibiotics. However, the high transmission rate and lethality of pneumonic plague require international and mandatory case notification and quarantine of patients. Rapid diagnosis, therapy and barrier nursing are not only crucial for the individual patient but also for the prevention of further spread of the pathogen or of epidemics. Therefore, WHO emergency schedules demand the isolation of cases, identification and surveillance of contacts as well as control of zoonotic reservoir animals and vectors. These sanctions and effective antibiotic treatment usually allow a rapid containment of outbreaks. However, multiple antibiotic resistant strains of Y. pestis have been isolated from patients in the past. So far, no outbreaks with such strains have been reported.
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PMID:[Human plague and pneumonic plague : pathogenicity, epidemiology, clinical presentations and therapy]. 2596 43

Streptococci cause a variety of diseases, such as dental caries, pharyngitis, meningitis, pneumonia, bacteremia, endocarditis, erysipelas, and necrotizing fasciitis. The natural niche of this genus of bacteria ranges from the mouth and nasopharynx to the skin, indicating that the bacteria will inevitably be subjected to environmental changes during invasion into the host, where it is exposed to the host immune system. Thus, the Streptococcus-host interaction determines whether bacteria are cleared by the host's defenses or whether they survive after invasion to cause serious diseases. If this interaction was to be deciphered, it could aid in the development of novel preventive and therapeutic agents. Streptococcus species possess many virulent factors, such as peroxidases and heat-shock proteins (HSPs), which play key roles in protecting the bacteria from hostile host environments. This review will discuss insights into the mechanism(s) by which streptococci adapt to host environments. Additionally, we will address how streptococcal infections trigger host stress responses; however, the mechanism by which bacterial components modulate host stress responses remains largely unknown.
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PMID:Stress responses in Streptococcus species and their effects on the host. 2650 57

Yersiniosis is an acute or chronic, zoonotic disease caused by infection of Gram-negative rods Yersinia enterocolitica. It can be transmitted by the consumption of originally contaminated food products (pork, unpasteurized milk) or secondarily contaminated with animal or vegetable products. The clinical picture of infection may have a variable course is related to the age and physical condition of the patient, or pathogenic properties of microorganisms. Infection caused by Y. enterocolitica can occur in different clinical forms: food poisoning, colitis, mesentric lymphadenitis, erythema nodosum, arthritis, pharyngitis, pneumonia, meningitis, sepsis. The aim of this study was to present a rare case of infection with Y. enterocolitica mesenteric lymph nodes coexistent with appendicitis.
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PMID:Mesenteric lymphadenitis caused by Yersinia enterocolitica. 2655 44


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