Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031154 (peritonitis)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of A3 adenosine receptors (ARs) in sepsis and inflammation is controversial. In this study, we determined the effects of A3AR modulation on mortality and hepatic and renal dysfunction in a murine model of sepsis. To induce sepsis, congenic A3AR knockout mice (A3AR KO) and wild-type control (A3AR WT) mice were subjected to cecal ligation and double puncture (CLP). A3AR KO mice had significantly worse 7-day survival compared with A3AR WT mice. A3AR KO mice also demonstrated significantly higher elevations in plasma creatinine, alanine aminotransferase, aspartate aminotransferase, keratinocyte-derived chemokine, and TNF-alpha 24 h after induction of sepsis compared with A3AR WT mice. Renal cortices from septic A3AR KO mice exhibited increased mRNA encoding proinflammatory cytokines and enhanced nuclear translocation of NF-kB compared with samples from A3AR WT mice. A3AR WT mice treated with N6-(3-iodobenzyl)ADO-5'N-methyluronamide (IB-MECA; a selective A3AR agonist) or 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS-1191; a selective A3AR antagonist) had improved or worsened 7-day survival after induction of sepsis, respectively. Moreover, A3AR WT mice treated with IB-MECA or MRS-1191 showed acutely improved or worsened, respectively, renal and hepatic function following CLP. IB-MECA significantly reduced mortality in mice lacking the A1AR or A2aAR but not the A3AR, demonstrating specificity of IB-MECA in activating A3ARs and mediating protection against sepsis-induced mortality. We conclude that endogenous or exogenous A3AR activation confers significant protection from murine septic peritonitis primarily by attenuating the hyperacute inflammatory response in sepsis.
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PMID:A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis. 1677 64

The aim of the study was to present difficulties and problems of dialytic treatment in children with spina bifida (SB). Between 2000 and 2005 five girls with SB and neurogenic bladder were treated with renal replacement therapy (15% of all children with end stage kidney disease dialyzed at our centre). Four patients (pts) had hydrocephalus requiring ventriculoperitoneal shunt, they were wheelchair-bound due to lower limbs paralysis and mentally retarded. Only 1 girl had been supervised by nephrologist from the very beginning. Dialysis was started at the age of 3-17 yr and the first mode was automatic peritoneal dialysis (ADO) in 3 and hemodialysis (HD) in 2. During the treatment ADO was switched onto HD in 2 pts for sclerosing encapsulating peritonitis (1) and tunnel infection with spontaneous Tenckhoff catheter evacuation (1). Permanent central venous catheters served as vascular access in 3 cases, in 2 there were difficulties with creation of arteriovenous fistula. No neurological complications were noticed in pts with ventriculo-peritoneal shunt and ADO. Total period of renal replacement therapy was 9-99 mo. Only 2 pts were qualified to transplantation. Two pts died after 16 mo of dialysis, 2 were transplanted and 1 is still being treated with HD. All families were dysfunctional. In 4 cases insufficient parental support caused many disturbances during predialytic and dialytic period. We concluded that in Poland pediatric pts with SB create specific group with the number of problems and complications higher than in other children on dialysis.
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PMID:[A child with myelomeningocele as a dialytic patient]. 1689 23