Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031154 (peritonitis)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The peritoneal surface of the lesion was observed after treatment by scanning electron microscopy (SEM) to evaluate the anticancer effect of Cisplatinum (CDDP). CDDP (0.1 mg/day bolus) was injected intraperitoneally to the DDN mice in which 3 X 10(7) MM2 tumor cells were inoculated the day before treatment. The anticancer effect was examined from 2nd to 7th consecutive day after tumor cells implantation, and the following results were obtained. 1) MM2 tumor cells were covered by powder-like material consisted with CDDP and were destroyed. 2) Mesothelial cells were also degenerated by powder-like material of CDDP. 3) In CDDP group, only a little intraperitoneal effusion and adhesion were observed. 4) These results suggested that CDDP exerted anti-tumor cell effects on peritonitis carcinomatosa.
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PMID:[Scanning electron microscopic observation of mouse ascitic carcinoma cells after intraperitoneal chemotherapy with cisplatinum]. 280 75

The peritoneal surface of the lesion was observed after treatment by scanning electron microscopy to evaluate the anticancer effect of FT-207. FT-207 (1.0 mg/day) was injected intraperitoneally to the DDN mice in which 3 X 10(7) MM2 tumor cells were inoculated the day before treatment. The anticancer effect was examined from 2nd to 7th consecutive day after tumor cell implantation, and the following results were obtained. 1) In the early phase after injection of FT-207, many macrophage-like cells were observed on the peritoneal surface. 2) Each MM2 tumor cell was covered by many macrophage-like cells, and these tumor cells were destroyed. 3) In the late phase after injection of FT-207, tumor cells were hyperplastic on the peritoneal surface, but less prominent than in the control group. 4) Effusion and adhesion in peritonitis carcinomatosa of FT-207 group were less than in the control group.
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PMID:[Intraperitoneal administration of FT-207 for mouse peritonitis carcinomatosa]. 642 98