Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031154 (peritonitis)
 15,372 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Randomized studies of combined treatment of 138 patients with toxic phase of general peritonitis were accomplished. We demonstrated a significant decrease in electric activity of the intestine and alteration of free-radical processes in patients with generalized purulent peritonitis. Administration of reamberin which contains succinic acid promoted restoration of the intestine's peristalsis to the 3rd day of postoperative period and effective correction of imbalance in free-radical processes system. Usage of reamberin in combined treatment of general peritonitis let lethality to be diminished from 16.49 to 9.76%.
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PMID:[Reamberin in combined therapy of general peritonitis]. 2033 47

Violation of the structural integrity and functional activity of mitochondria in the muscular coat of small intestine is among the main factors responsible for enteroparesis under conditions of widespread purulent peritonitis. This morphofunctional disorder leads to a sharp decrease in ATP synthesis, which is directly related to a low electric activity of parts of the small intestine. The drug reamberin that contains succinic acid favors elimination of the dysfunction of enterocyte mitochondria and restoration of the intestinal motility under conditions of widespread purulent peritonitis.
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PMID:[Use of reamberin for correction of enterocyte functional activity in experimental disseminated purulent peritonitis]. 2036

Lipid spectrum of liver mitochondria has been studied in a group of 46 Chinchilla rabbits with experimental widespread purulent peritonitis. It is established that the drug reamberin that contains succinic acid produces a positive effect on the protein spectrum of liver mitochondria under these conditions, which is manifested by a decrease in the content of lysophosphatidylcholine and increases the levels of polyglycerophosphatides and sphyngomyelin.
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PMID:[Effect of reamberin on the lipid spectrum of the liver mitochondria in experimental widespread purulent peritonitis]. 2040 28

Experiments on 55 male chinchilla rabbits with model widespread purulent peritonitis have been performed for determinig structural changes in adrenal glands with the aid of optical microscopy. The introduction of aerobic-anaerobic culture of E. Coli and B. Fragilis into the abdominal cavity causes expressed structural changes in parenchyma of adrenal glands within 6 hours. It is established for the first time that the administration of metabolic drugs citoflavin (containing succinic acid) and neoton (containing creatine phosphate) prevents the development of pathological structural changes in adrenal glands under conditions of experimental widespread purulent peritonitis.
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PMID:[Metabolic correction of structural changes in adrenal glands during experimental widespread purulent peritonitis]. 2289 42

One of the most powerful damaging factors during inflammation is hyperactivation of the free-radical oxidation processes. The condition of lipid peroxidation (LPO) and antioxidant activity (AOA) systems in liver has been studied in experiment on 55 male Chinchilla rabbits with widespread purulent peritonitis (WPP) model. The development of WPP leads to expressed of free-radical oxidation processes in liver that is manifested by systemic accumulation of toxic LPO products and a decrease in the activity of antioxidants. Comparative study of the influence of metabolic drugs citoflavin and neoton on the LPO and AOA systems has been conducted. It is established that citoflavin (containing succinic acid) exhibits more pronounced antioxidant properties, provides effective and fast restoration of the balance of LPO and AOA processes, and increases the speed of elimination of free radical.
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PMID:[Free-radical oxidation in liver during experimental widespread purulent peritonitis]. 2324 Jan 57