Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0031117 (peripheral neuropathy)
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Human Gene/Protein
desert hedgehog homolog (Drosophila) 11.6
prion protein precursor 11.6
SLC12A6 10.7
SH3TC2 protein 10.6
SPTLC1 protein 10.6
ZFHX2 10.6
CMT4E 10.6
EFCAB8 10.6
C5orf17 10.6
MHS3 10.6
cat eye syndrome chromosome region, candidate 1 10.6
K-Cl cotransporter 3 10.2
CMTX5 10.1
ANAPC5 10.0
CSHL1 10.0
Contactin-associated protein 2 10.0
KIAA0188 10.0
THEM5 10.0
C1orf194 10.0
AP1B1 10.0
PTRH2 9.7
SLC25A46 9.6
DI-CMTC 9.6
glutathione S-transferase theta 2 9.6
Protocadherin-10 9.6
AGPAT2 protein 9.6
ARSACS 9.6
CMT2A 9.4
CMT4B 9.4
FGD4 9.4
CMT4F 9.3
C12orf65 9.2
V1-18 9.2
WD repeat domain, phosphoinositide interacting 1 9.2
FAM126A 9.2
CMT4B1 9.2
CEP72 9.2
GDAP1L1 9.0
MTMR5 9.0
GJE1 9.0
CTDP1 9.0
KCMF1 9.0
OTF6 9.0
SH3TC2 8.9
peripheral myelin protein 22 8.8
connexin 31 8.8
MTATP6 8.8
Gal3ST-3 8.7
Hyccin 8.7
NRG-4 8.7
SLC12A4 8.7
ARHGEF10 8.7
KCC3 8.7
SACS 8.7
SCN11A 8.6
SARM1 8.6
C10orf2 8.6
heat shock protein beta-8 8.6
NRF1 protein 8.6
NALP2 8.6
Diaphanous 1 8.6
CCC6 8.6
periaxin 8.5
NMNAT2 8.5
MTMR2 8.5
CMT1A 8.5
TRIM2 8.5
CMT1 8.5
PMP22 protein 8.5
APTX 8.4
KIAA1840 8.4
SBF2 8.4
SCYL1 8.4
MCM3AP 8.4
Rho guanine nucleotide exchange factor 10 8.4
SPTLC1 8.4
SAC3 8.3
HADHB 8.3
CMT2 8.3
FIG4 8.3
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Disease
Axonal sensorimotor neuropathy 11.6
EKV3 11.6
Deficiency of glutamate dehydrogenase 11.6
vitamin abuse 11.6
Idiopathic progressive neuropathy 11.6
Plantar Ulcer 11.6
Familial visceral neuropathy 11.6
peripheral neuropathy 11.6
progressive neural muscular atrophy 11.6
Chronic sarcoid myopathy 11.6
SPG26 11.6
Strachan's syndrome 10.6
SCA18 10.6
Total dystrophic onychomycosis 10.6
Gaisbock's syndrome 10.6
CMT2A2 10.6
HIV peripheral neuropathy 10.6
Andermann syndrome 10.3
CMTX5 10.2
Early onset cerebellar ataxia with retained tendon reflexes 10.2
Mononeuropathy multiplex 10.2
Hereditary amyloidosis 10.2
Ischemic neuropathy 10.1
megalocytic anemia 10.0
Amyloid neuropathy 10.0
Early Onset Cerebellar Ataxia 10.0
DFN2 10.0
Mitochondrial neurogastrointestinal encephalopathy 10.0
Peripheral sensorimotor neuropathy 10.0
Cytolytic hepatitis 10.0
CMT4G 10.0
CMT2B1 10.0
DI-CMTC 10.0
stage III Wilms' tumor 10.0
Vascular encephalopathy 10.0
CMT2B2 10.0
CMT4B2 9.9
HIV neuropathy 9.8
Acyl-CoA dehydrogenase deficiency 9.7
Behr syndrome 9.7
CMT2E 9.6
Diabetic peripheral neuropathy 9.6
Paraneoplastic neuropathy 9.6
PMLD1 9.6
CMT2L 9.6
CMT1E 9.6
Osteosclerotic myeloma 9.6
Diabetic gastropathy 9.6
uterine cyst 9.6
Tropical ataxic neuropathy 9.6
Gopalan 9.4
Bullosis diabeticorum 9.4
CMT4B1 9.4
Motor neuropathy 9.3
CMTX 9.3
meningoencephalopathy 9.2
CMT1C 9.2
Multiple symmetrical lipomatosis 9.2
CMT4D 9.2
SCA20 9.2
Spastic ataxia 9.2
SCA25 9.2
CMTX4 9.2
Trigeminal neuropathy 9.1
CMT2K 9.1
Mononeuritis multiplex 9.1
SACS 9.1
Essential mixed cryoglobulinemia 9.1
Secondary erythromelalgia 9.0
Superficial white onychomycosis 9.0
Dialysis dementia 9.0
Mitochondrial trifunctional protein deficiency 9.0
Sarcoid neuropathy 9.0
WFS2 9.0
Neurodevelopmental disorder 9.0
IgA MGUS 9.0
thymus cancer 9.0
Dyschromatopsia 9.0
Malignant pyoderma 9.0
CMTX3 9.0
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Symptom
Cherry red spot 11.6
Decreased deep tendon reflexes 11.6
Taste alteration (dysgeusia) 11.6
Trepopnea 10.6
neuromuscular manifestation 9.6
Excruciating pain 9.6
Sensory ataxia 9.5
Nausea, vomiting and diarrhea 9.0
Myokymia 8.7
jaundice of the skin 8.6
sense loss 8.2
Painful legs and moving toes 8.2
Lhermitte's sign 8.2
Pyramidal signs 8.0
Peripheral neuropathic pain 7.6
Mechanical pain 7.5
Livedoid 7.5
Action myoclonus 7.4
Local reaction 7.4
loss of feeling 7.4
Flaccid paralysis 7.4
tingling 7.3
cerebellar ataxia 7.1
numbness 7.0
Neuropathic pain 6.9
Cramping 6.9
paresthesia 6.9
Severe diarrhea 6.7
Central post-stroke pain 6.7
ataxic gait 6.7
Chronic pelvic pain syndrome 6.7
intention tremor 6.7
General symptoms 6.7
dysesthesia 6.7
GI irritation 6.6
nerve root irritation 6.6
Spastic paraparesis 6.5
Cold intolerance 6.4
Signs and Symptoms 6.4
asterixis 6.4
diminished hearing 6.4
Ataxic 6.4
ophthalmoplegia 6.4
nerve pain 6.4
Neurologic symptoms 6.4
polymyalgia 6.3
dry throat 6.2
ataxia 6.1
Urticarial vasculitis 6.1
paraparesis 6.0
Fear of falling 6.0
Fear of falling 6.0
Foot pain 6.0
Hemiballism 6.0
leg cramps 5.9
Pain symptoms 5.7
asthenia 5.6
myalgia 5.5
dysarthria 5.5
giddiness 5.5
Skin symptoms 5.4
weakness 5.4
abnormal gait 5.4
livedo 5.4
Kayser-Fleischer ring 5.3
inanition 5.3
chorea 5.3
muscle cramps 5.3
hyperesthesia 5.3
skin pain 5.3
Hemicrania 5.1
fasciculation 5.1
hypalgesia 5.1
Flare 5.1
loss of balance 5.1
nausea and vomiting 5.1
orthopnea 5.0
arthralgia 5.0
Gastrointestinal symptoms 5.0
growing pains 4.9
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Drug
Succinic Acid 10.0
Perhexiline maleate 9.7
Hivid 8.7
Oxaliplatin 8.6
Zenarestat 8.6
Epalrestat 8.5
Carbetimer 8.2
Vindesine 8.2
Nelarabine 8.1
Vindesine 8.1
Bortezomib 8.1
Paclitaxel poliglumex 8.1
Lipoic Acid 8.0
Tanespimycin 8.0
Vectarion 8.0
Propafenone hydrochloride 7.9
Clinoril 7.9
Ormaplatin 7.9
Mecobalamin 7.9
Ixabepilone 7.8
Naphtha 7.7
Propafenone HCl 7.7
Lafutidine 7.6
Alrestatin 7.6
Duloxetine 7.5
Pregabalin 7.5
Pronestyl 7.5
Benfotiamine 7.4
SR 57746A 7.4
Bendazac 7.3
ddI 7.2
Tapentadol 7.1
Miglustat 6.9
Elcatonin 6.8
Fidarestat 6.7
Minocin 6.7
Fidarestat 6.7
Muzolimine 6.7
Perhexiline 6.7
Duloxetine hydrochloride 6.6
Polaprezinc 6.6
Ddc 6.5
Domperidone 6.4
Navelbine 6.4
Taxol 6.3
Doxifluridine 6.3
Januvia 6.3
Mercaptopurine 6.2
Paraplatin 6.0
Vinorelbine 6.0
Teniposide 6.0
Cremophor EL 6.0
Ascorbic Acid 5.9
Lenalidomide 5.9
Epidoxorubicin 5.8
RPH 5.8
Ibudilast 5.7
Docetaxel 5.6
Flecainide acetate 5.6
Taxotere 5.6
Vitamin B 5.6
NAH 5.6
Leucovorin 5.6
Gabapentin 5.6
Flecainide acetate 5.5
Fotemustine 5.5
Revlimid 5.4
PDGF B-chain 5.1
Epivir 5.1
Valganciclovir 5.0
Pegasys 5.0
Implanon 5.0
Sodium thiosulfate 5.0
Vitamin B12 4.9
Rifaximin 4.9
CTC 4.8
Aztec 4.8
Ethyol 4.8
AZT 4.8
Atropine sulfate 4.7
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Enzyme
phytanoyl-CoA hydroxylase 8.3
NMN deamidase 7.6
N-acetylglucosaminyltransferase II 7.2
glycyl-tRNA synthetase 7.2
BCKDH 7.0
neurosin 6.5
maleylacetoacetate isomerase 6.5
thymidine phosphorylase 6.3
m-AAA protease 6.0
acylglycerol kinase 5.9
alanyl-tRNA synthetase 5.8
collagenase 3 5.6
histidyl-tRNA synthetase 5.6
aldose reductase 5.5
phosphatidate phosphatase 5.4
3-hydroxyacyl-CoA dehydrogenase 5.3
porphobilinogen deaminase 5.2
pantothenate kinase 5.2
deoxycytidine deaminase 5.1
arylsulfatase A 5.1
asparaginyl-tRNA synthetase 5.1
CYP27A1 5.1
squalene epoxidase 5.0
3-hydroxyacyl-CoA dehydrogenase 4.9
SPT 4.9
galactocerebrosidase 4.9
ribose-5-phosphate isomerase 4.7
alpha-methylacyl-CoA racemase 4.7
phosphomannomutase 4.7
MTD 4.7
PRPP synthetase 4.6
carnosinase 4.6
nicotinamide mononucleotide adenylyltransferase 4.6
dihydropyrimidine dehydrogenase 4.5
transketolase 4.4
fumarylacetoacetate hydrolase 4.4
dihydropyrimidine dehydrogenase 4.3
NMT 4.2
3'-phosphatase 4.1
kynurenine aminotransferase 4.1
carboxypeptidase G2 4.0
nicotinamide phosphoribosyltransferase 4.0
CEP 4.0
kynureninase 4.0
ALA synthase 3.9
NAD glycohydrolase 3.8
GM3 synthase 3.8
phosphocholine cytidylyltransferase 3.8
pyridoxal kinase 3.8
choline kinase 3.8
15-lipoxygenase 3.7
aspartyl-tRNA synthetase 3.7
3-mercaptopyruvate sulfurtransferase 3.7
glucosylceramide synthase 3.6
asparaginase 3.6
PHT 3.6
isoleucyl-tRNA synthetase 3.6
thrombin-activatable fibrinolysis inhibitor 3.6
coproporphyrinogen oxidase 3.6
neuropathy target esterase 3.5
methionine synthase 3.4
CEP 3.4
dihydropyrimidinase 3.4
serine racemase 3.4
methionine synthase 3.3
branching enzyme 3.3
proteasome 3.2
PDK1 3.2
phosphoglycerate dehydrogenase 3.2
ferredoxin reductase 3.2
granule-bound starch synthase 3.2
BAL 3.2
alpha-galactosidase 3.1
proteinase-3 3.1
Omi/HtrA2 3.1
mu-calpain 3.1
GCA 3.1
acyl-CoA dehydrogenase 3.1
prostacyclin synthase 3.0
kinesin 3.0
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Compound
N,N-diethylpentanamide 11.6
Butrin 10.6
Dimethylaminopropionitrile 10.0
Isosakuranetin 9.2
Oxycodone hydrochloride 8.6
2,5-hexanediol 8.2
Didanosine 8.2
Etanidazole 8.0
3-Deazaneplanocin 8.0
Misonidazole 8.0
Vincristine 7.8
Paclitaxel 7.6
d4T 7.5
DPN 7.5
2,4-hexanedione 7.5
2-ethylphenol 7.2
Tolrestat 7.1
1,5-isoquinolinediol 7.1
2,5-hexanedione 7.1
3-heptanol 7.0
C10H14 7.0
Spartin 7.0
Acetyl-L-carnitine 7.0
Phytanic acid 6.8
Rhizoxin 6.7
Ribose 5-phosphate 6.7
Cyanocobalamin 6.6
TPTA 6.5
Pyridoxine 6.5
2-hexanol 6.5
Olsalazine 6.4
Nornicotine 6.4
Nicotinamide riboside 6.4
Amiodarone hydrochloride 6.4
hexan-2-one 6.3
Neo 6.2
Aucubin 6.2
Mechlorethamine 6.1
Cholestanol 6.1
cholest-4-en-3-one 6.0
Atropine sulfate 5.9
Capecitabine 5.9
NDS 5.8
Docetaxel 5.8
Notoginsenoside R1 5.8
Ornidazole 5.8
Palmitoylethanolamide 5.7
NAAG 5.7
Dichloroacetate 5.7
2-heptanol 5.6
Ethoxyquin 5.6
Benztropine 5.6
Sulfatide 5.5
Linezolid 5.5
Bergapten 5.5
Sorbinil 5.4
Dimethyl fumarate 5.4
Erythrosin 5.4
ITG 5.3
CBDCA 5.3
CBDCA 5.3
Thiamine 5.3
N,N-diethylacrylamide 5.3
DDP 5.2
Mesna 5.2
cephalotaxine 5.2
MGBG 5.2
MGBG 5.2
Trigonelline 5.2
Resiniferatoxin 5.1
Diallyl sulfide 5.1
1,2,3-trichloropropane 5.1
3-heptanone 5.1
cephalotaxine 5.1
3-heptanone 5.1
Noscapine 5.0
Quinupristin 5.0
Trifluorothymidine 5.0
Methylsulfonylmethane 5.0
1-methylhistidine 5.0
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