Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0031099 (periodontitis)
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Human Gene/Protein
glycosyltransferase 6 domain containing 1 11.3
Periodontal ligament-associated protein 1 11.3
Fc-gamma receptor IIIb 11.3
TTLL11 10.3
ZNF57 10.3
chondroitinsulfatase 10.3
Apoptotic peptidase activating factor 1 10.3
ZNF675 10.3
GCF 9.8
chemokine receptor-like 1 9.7
HSP90BB 9.7
RGP2 9.7
Proline aminopeptidase 9.7
ZNF823 9.7
ABHD12B 9.7
JP2 9.5
GP110 9.3
GPR141 9.3
Gp110 9.3
Radioprotective 105 kDa protein 9.3
EMD protein 9.3
CTSC 9.1
EEIG1 9.0
FBXO38 9.0
Sphingomyelin phosphodiesterase 3 9.0
SIGLEC5 8.9
MFSD1 8.7
Cytoskeleton-associated protein 2-like 8.7
tripartite motif-containing 22 8.7
putative tyrosine phosphatase 8.5
transposase-like protein 8.5
CSRP 8.5
CAPN8 8.5
cathepsin C 8.4
paraoxonase 3 8.3
T-cell protein-tyrosine phosphatase 8.3
BEGAIN 8.3
AP3B2 8.2
RagB 8.2
cementum protein 1 8.1
NFKBIL1 8.1
ZNF215 8.1
chemokine receptor-like 2 8.1
PLAP-1 8.1
SYT7 8.1
IFR1 8.1
interferon induced with helicase C domain 1 8.1
Del1 8.0
zymogen granule protein 16 homolog B 8.0
LECT1 8.0
GBGT1 7.9
TRIM52 7.9
TSNAX 7.9
FAM20A 7.9
DC-STAMP 7.8
p150(Sal2) 7.7
ribonuclease 7 7.7
SH3-domain binding protein 2 7.7
KRT23 7.7
MOSP 7.7
OSBPL10 7.7
microtubule-associated proteins 1A/1B light chain 3 7.7
CCT8 7.7
FGD5 7.7
FSL1 7.7
importin 8 7.6
DRiP78 7.6
WHAMM 7.6
KCNK1 7.6
MMP-8 7.6
DAP-1 7.5
ARHGEF5 7.5
CHI3L2 7.5
DPP7 7.4
osteoclast-associated receptor 7.4
SI-CLP 7.4
CCT3 7.4
HNP-3 7.3
TM9SF2 7.3
dendritic cell-specific transmembrane protein 7.3
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Disease
Attachment Loss, Periodontal 11.3
Reversible pulpitis 11.3
Gingival and periodontal diseases 11.3
periodontitis 11.3
Phoenix abscess 11.3
Refractory periodontitis 11.1
Linear gingival erythema 11.0
Rapidly progressive periodontitis 10.9
Adult periodontitis 10.8
Subgingival plaque 10.7
Apical periodontitis 10.7
Chronic apical periodontitis 10.6
Persistent deciduous teeth 10.6
Marginal periodontitis 10.5
Acute gingivitis 10.3
Chronic apical abscess 10.3
Ehlers-Danlos syndrome type VIII 10.3
juvenile periodontitis 10.3
Alveolar bone loss 10.1
ANUG 9.9
gingivitis 9.8
Ulcerative stomatitis 9.7
periodontal disease 9.5
dental deposit 9.5
Periodontal infection 9.4
periodontosis 9.4
Periapical disease 9.3
GEY 9.3
Inability to understand 9.3
Psoriasiform dermatitis 9.3
Early onset periodontitis 9.3
tooth loss 9.3
Irreversible pulpitis 9.1
gum disease 9.1
Periapical abscesses 9.0
pulpitis 8.9
Pseudomembranous candidiasis 8.7
Deep caries 8.7
pericoronitis 8.7
pyorrhea 8.7
Cemento-osseous dysplasia 8.6
enamel pearls 8.3
dens evaginatus 8.3
Supragingival plaque 8.2
Leukocyte adhesion deficiency 8.2
Pulp necrosis 8.2
Singleton-Merten syndrome 8.1
Garre 8.1
Empyema necessitans 7.9
Pyostomatitis vegetans 7.9
onychogryphosis 7.9
Tooth surface loss 7.9
Endodontic disease 7.9
Desquamative gingivitis 7.7
streptoccocal 7.7
Ehlers-Danlos syndrome type III 7.6
Palmoplantar keratoderma 7.6
Hepatic actinomycosis 7.5
Idiopathic gingival fibromatosis 7.5
dental calculus 7.3
Cyclic neutropenia 7.3
hairy leukoplakia 7.3
Gingival recession 7.3
tooth resorption 7.2
Plasminogen deficiency 7.2
dental root 7.2
Malassez 7.2
dental disorder 7.1
hairy tongue 7.1
Dentin dysplasia 7.1
Plaque 7.1
Gingival hyperplasia 7.0
gingivostomatitis 6.9
cheilosis 6.9
Gingival overgrowth 6.8
Neutrophil dysfunction 6.8
bone marrow cancer 6.8
hypercementosis 6.8
infected bite 6.5
Enamel hypoplasia 6.5
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Symptom
pain in the gums 11.3
temporomandibular joint problem 9.7
Sulfur granules 9.0
Premature loss of teeth 8.7
Burning mouth 8.0
halitosis 7.9
prickling sensation 7.4
ischuria 6.6
enanthema 6.6
Mechanical pain 6.3
hyperosmia 6.2
dental pain 5.7
microbial colonization 5.1
disturbed balance 5.1
scaly skin 4.9
No pain 4.5
Severe pain 4.0
hyperesthesia 3.9
pachyonychia 3.8
loss of taste 3.8
Postoperative pain 3.6
orofacial pain 3.4
swollen joints 3.3
No adverse effect 3.0
Tenderness 2.8
erythema 2.5
loss of balance 2.5
stomach pain 2.4
Decreased activity 2.3
ketonuria 2.2
adenitis 2.2
discomfort 2.1
excessive sweating 2.1
Fluctuation 2.1
discomfort 2.1
tachypnea 1.6
neuralgia 1.6
ENT 1.5
muscle cramps 1.5
sore throat 1.5
neurological disability 1.5
DNA marker 1.5
paresthesia 1.4
dry skin 1.3
numbness 1.3
bone pain 1.3
joint stiffness 1.3
productive cough 1.2
hypoproteinemia 1.2
pain 1.2
facial pain 1.1
arthralgia 1.1
pallor 1.0
Wind 1.0
distraction 0.9
hoarseness 0.8
anesthesia 0.8
polyuria 0.7
overweight 0.7
photophobia 0.7
abdominal discomfort 0.6
anorexia 0.6
incoordination 0.5
cachexia 0.4
neck pain 0.4
acute pain 0.4
twitching 0.3
heartburn 0.3
chills 0.3
hepatosplenomegaly 0.2
polydipsia 0.2
Ill 0.2
hopelessness 0.1
angina 0.1
dry eye -0.0
regurgitation -0.1
thinning -0.1
snoring -0.2
colic -0.3
myalgia -0.4
more...
Drug
DOXY 9.2
Clavamox 9.0
Vibramycin 8.7
Dichlorophenamide 8.5
Cleocin 8.1
Minocin 8.1
Alendronate sodium 7.7
Maxacalcitol 7.1
Meclomen 6.7
Lumiracoxib 6.7
Cinnamon bark 6.7
Augmentin 6.6
Miocamycin 6.6
Augmentin 6.5
Tantum 6.5
Iodipamide 6.5
MINO 6.4
Emla 6.4
Sitafloxacin 6.4
Meclomen 6.3
Unasyn 6.3
PDL 6.3
Belladonna 6.3
Dalacin 6.1
CZON 6.1
Tinidazole 5.8
Peridex 5.8
SnF2 5.7
Calcium gluconate 5.7
Ethylcellulose 5.7
Aredia 5.7
Sodium hypochlorite 5.7
Dilantin 5.6
Ketorolac tromethamine 5.5
Peridex 5.5
Doxycycline 5.5
Zaditen 5.5
Butaprost 5.4
Midostaurin 5.3
Esculin 5.3
Amoxicillin 5.3
OMP 5.3
DEL 5.2
IL-1ra 5.2
Dodecyl Sulfate 5.2
Calcium silicate 5.1
Fosamax 5.1
Azithromycin 4.9
Batimastat 4.8
Batimastat 4.8
Carbopol 934P 4.7
Myricetin 4.6
AMC 4.6
Teriparatide 4.5
CA-074 4.5
Ara-A 4.5
Etodolac 4.3
RAL 4.3
Citric acid 4.3
Zein 4.2
Nimesulide 4.1
Surgicel 4.1
ROX 4.1
Moxifloxacin 4.0
Soybean oil 4.0
TTC 4.0
Beta-2 3.9
Artesunate 3.9
Tetanus toxoid 3.9
Simvastatin 3.8
IL-11 3.8
Abatacept 3.7
Dextrose 3.7
EFV 3.7
Hypaque 3.6
Poloxamer 3.6
Hypaque 3.5
Calcium chloride 3.5
TAC 3.5
Zoledronic acid 3.3
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Enzyme
chondroitinsulfatase 10.3
Lys-gingipain 10.0
RGP 9.1
EC 2.8.3.9 9.0
cathepsin C 8.1
neutrophil collagenase 7.8
mycothione reductase 7.7
peptidylarginine deiminase 7.4
hydroxylamine reductase 7.3
hydroxylamine reductase 7.3
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 7.3
CbiX 6.9
N-acetylglucosamine-6-sulfatase 6.7
phosphoamidase 6.0
acetylornithine aminotransferase 6.0
cathepsin K 6.0
methylglyoxal synthase 5.6
KLK13 5.6
arginine deiminase 5.6
LuxS 5.4
cathepsin V 5.3
collagenase 3 5.3
proline iminopeptidase 5.3
cyanase 5.3
phosphoenolpyruvate synthase 5.3
nicotinamide phosphoribosyltransferase 5.1
cystathionine gamma-lyase 5.1
collagenase 4.9
IgA1 protease 4.8
cathepsin G 4.8
MMP-3 4.7
Hageman factor 4.6
neutrophil elastase 4.6
interstitial collagenase 4.4
penicillopepsin 4.4
lysyl hydroxylase 4.4
IgA protease 4.4
glycyl-tRNA synthetase 4.4
NADH peroxidase 4.3
elastase 4.3
PAL 4.2
tripeptidyl peptidase 4.2
prolinase 4.2
alpha-L-fucosidase 4.1
fatty-acid synthase 4.0
methyl coenzyme M reductase 3.9
cathepsin S 3.9
dipeptidyl peptidase IV 3.9
inositol phosphatase 3.9
PAL 3.8
lysine acetyltransferase 3.8
tryptase 3.8
matrix metalloproteinase 9 3.7
MMP 3.7
arylsulfatase 3.6
cathepsin B 3.6
aminopeptidase P 3.6
aminopeptidase B 3.6
caspase-1 3.5
sialidase 3.5
PRT 3.5
SCP 3.5
SMP 3.5
beta-glucuronidase 3.5
iduronate-2-sulfatase 3.4
NCP 3.4
proteinase K 3.3
AGT 3.3
C3 convertase 3.3
TACE 3.3
pyruvate oxidase 3.2
pyruvate oxidase 3.2
SpeB 3.2
dissimilatory sulfite reductase 3.1
matrix metalloproteinase 2 3.1
histidine decarboxylase 3.1
C3 convertase 3.0
fumarate reductase 3.0
ceramidase 2.9
caspase-11 2.9
more...
Compound
1-chloroisoquinoline 10.3
N-Phenylmaleimide 9.0
2,4,8,10-tetraoxaspiro[5.5]undecane 8.7
N-Phenylmaleimide 8.3
Fentiazac 8.3
New Methylene Blue 8.1
Clindamycin hydrochloride 8.1
Clindamycin hydrochloride 8.0
Plantamajoside 8.0
Resolvin D2 7.7
DuP 697 7.7
Tetracycline hydrochloride 7.7
No. 118 7.6
Kavain 7.4
SP-G 7.1
1,2,6-hexanetriol 7.1
Calcium hydroxide 7.1
TBO 7.1
Dehydrocostus lactone 7.1
Zwittergent 3-14 7.0
Thiolactomycin 6.9
Angelicin 6.9
Stachydrine 6.8
PD 5 6.7
BOP 6.6
Spiramycin 6.6
Ornidazole 6.5
1,10-decanediol 6.5
Spiramycin 6.5
Acetylshikonin 6.5
Phenidone 6.5
Tamibarotene 6.5
Josamycin 6.5
Josamycin 6.4
Josamycin 6.4
Sitafloxacin 6.4
Z-Gly 6.4
Cryptoxanthin 6.3
Plastoquinone 6.3
GDP-4-keto-6-deoxy-D-mannose 6.3
Chlorhexidine 6.2
Stachydrine 6.0
Laminariaceae 6.0
CD 3 5.8
PPBP 5.8
Minocycline 5.7
Homogentisate 5.7
Etoricoxib 5.7
Cetylpyridinium chloride 5.6
DPBS 5.6
Daidzin 5.5
Doxycycline 5.5
Alizarin Red S 5.4
Nitrosamine 5.4
isopropyl palmitate 5.4
Acacetin 5.3
Carnosol 5.3
dibutyl sebacate 5.3
PYC 5.3
Esculin 5.3
Catalpol 5.3
CLTC 5.3
Amoxicillin 5.2
D-Tagatose 5.2
Anethole 5.2
W37 5.2
OMP 5.2
Penicillin V 5.1
20-Hydroxyecdysone 5.1
Niridazole 5.1
3-Nitrotyrosine 5.1
Escin 5.1
Azithromycin 5.0
Escin 5.0
Clindamycin 5.0
iodoform 5.0
Alizarin 5.0
Cetylpyridinium chloride 5.0
Tetracycline 5.0
PGB1 4.9
more...