Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
766
cytokine
590
lipopolysaccharide
492
Mol
393
IL-6
389
collagen
362
TNF
348
IL-8
250
RANKL
241
tumor necrosis factor
212
LPS
174
IL-1
160
osteogenic
153
IL-10
152
TLR4
148
insulin
143
IgA
137
TLR2
132
alkaline phosphatase
116
matrix metalloproteinase
113
C-reactive protein
113
interleukin-6
112
CD4
111
IL-17
108
collagenase
108
osteoprotegerin
107
IL-1 beta
101
tumor necrosis factor alpha
90
p38
90
TNF-alpha
87
Cytokine
87
IL-4
85
hemoglobin
82
MMP-9
81
MMP-8
81
chemokine
76
IFN
72
kit
69
tartrate-resistant acid phosphatase
68
SDS
67
interferon
66
THP
65
ANOVA
63
CD14
62
fibronectin
61
RANK
61
myeloperoxidase
60
p65
58
inducible nitric oxide synthase
55
membrane protein
55
gut
54
osteocalcin
53
JNK
50
MMP-1
49
CD8
49
cathepsin C
49
TRAP
48
MAPK
48
type I collagen
48
OPG
47
GCF
47
IFN-gamma
47
Gen
46
cathepsin K
46
cyclooxygenase-2
44
COX-2
43
macrophage colony-stimulating factor
42
IL-2
42
PLS
42
MMP-2
41
CAL
41
lactoferrin
41
catalase
40
ERK
40
vascular endothelial growth factor
39
SRP
39
superoxide dismutase
39
aspartate aminotransferase
38
JP2
38
CD18
37
more...
Disease
periodontitis
12489
periodontal disease
2404
plaque
1846
gingivitis
1283
diabetes
662
tooth loss
525
rheumatoid arthritis
344
dental caries
325
juvenile periodontitis
297
infectious diseases
267
cardiovascular disease
232
cancer
214
atherosclerosis
214
osteoporosis
209
Plaque
188
type 2 diabetes
161
HIV
152
obesity
149
bacterial infection
137
Subgingival plaque
132
pulpitis
119
systemic disease
105
edentulous
103
arthritis
102
hypertension
102
stroke
93
Alzheimer's disease
81
immunodeficiency
77
AIDS
76
tumor
75
endocarditis
70
coronary heart disease
69
oral cancer
69
SDS
68
bacteremia
68
aggression
65
hyperkeratosis
63
metabolic syndrome
59
osteomyelitis
56
hyperglycemia
53
cytomegalovirus
53
Epstein
52
myocardial infarction
52
pneumonia
52
xerostomia
52
candidiasis
52
squamous cell carcinoma
51
Apical periodontitis
49
PLS
48
Infection
48
stomatitis
47
Haemophilus
47
depression
46
osteoarthritis
46
chronic disease
45
coronary artery disease
43
Alveolar bone loss
42
SEM
41
type 1 diabetes
40
asthma
37
Down syndrome
35
dental calculus
34
psoriasis
33
oral candidiasis
33
inflammatory bowel disease
32
chronic obstructive pulmonary disease
32
herpes simplex
32
Caries
31
sepsis
31
neutropenia
30
autoimmune disease
30
malnutrition
29
Crohn's disease
29
hairy leukoplakia
28
sinusitis
28
cold
27
systemic lupus erythematosus
27
Kaposi's sarcoma
27
pericoronitis
26
sepsis
26
more...
Symptom
pain
229
anesthesia
73
halitosis
54
discomfort
40
discomfort
39
erythema
30
dental pain
25
diarrhea
17
overweight
17
microbial colonization
14
angina
9
fatigue
8
anorexia
8
headache
7
distraction
7
ENT
6
weakness
6
arthralgia
6
Ill
5
paresthesia
5
Postoperative pain
5
numbness
5
analgesia
5
collapse
4
thinning
4
orofacial pain
4
respiratory distress
4
chest pain
4
agitation
3
splenomegaly
3
regurgitation
3
bone pain
3
tachypnea
3
hyperesthesia
3
acidity
3
sore throat
3
insomnia
3
back pain
3
vomiting
3
cachexia
3
disturbed balance
3
abdominal pain
3
nausea
3
pallor
2
loss of taste
2
starvation
2
scaly skin
2
sleepiness
2
facial pain
2
polyuria
2
swollen joints
2
neuralgia
2
myalgia
2
hepatosplenomegaly
2
exhaustion
2
seizures
2
hoarseness
2
acute pain
2
Wind
2
chills
2
neck pain
2
adenitis
1
apathy
1
photophobia
1
spasm
1
stomach pain
1
No adverse effect
1
Decreased activity
1
paresis
1
constipation
1
cough
1
Sulfur granules
1
neurological disability
1
DNA marker
1
nausea and vomiting
1
hopelessness
1
Fluctuation
1
enanthema
1
productive cough
1
loss of balance
1
more...
Drug
lysine
66
Dermatol
47
IFN-gamma
46
IL-2
42
citric acid
24
ascorbate
23
PDL
20
IL-1ra
20
Doxycycline
19
ROS
18
Gel
18
ampicillin
17
CSF
17
Azithromycin
14
Amoxicillin
14
Monit
13
TTC
12
Vibramycin
12
DOXY
12
Cardiovasc
12
Bifidobacterium
11
AMC
11
Augmentin
10
Augmentin
10
vitamin E
10
Heme
9
Simvastatin
9
CAM
9
lactose
9
Asthma
8
ENT
8
ABC
7
OMP
7
ROC
7
TAC
7
CTX
6
CaCl2
6
Hypaque
6
IL-11
6
CTX
6
CTX
6
CaCl2
6
CaCl2
6
Albumin
5
SnF2
5
G-CSF
5
Peridex
5
Sodium hypochlorite
5
DEL
5
Indomethacin
5
Hypaque
5
ACT
4
CCL
4
SiO2
4
NADH
4
Gelatin
4
Paraffin
4
Histamine
4
Phenytoin
4
Asn
4
Citric acid
4
FLP
4
MAP
4
DNase I
4
Dilantin
3
Zoledronic acid
3
Tinidazole
3
Triclosan
3
MINO
3
Aloe
3
EPA
3
Minocin
3
Spectrum
3
ADM
3
NBT
3
Ethanol
3
Moxifloxacin
3
Myricetin
3
Ringer's solution
3
Teriparatide
3
more...
Enzyme
collagenase
220
mitogen-activated protein kinase
180
alkaline phosphatase
117
peroxidase
90
trypsin
77
elastase
70
ERK
63
RGP
48
cathepsin K
46
catalase
44
superoxide dismutase
44
Lys-gingipain
42
cathepsin C
42
aspartate aminotransferase
41
neutrophil elastase
39
MMP-3
36
lactate dehydrogenase
35
acid phosphatase
34
beta-glucuronidase
33
focal adhesion kinase
29
caspase-1
28
caspase-3
26
protein kinase
25
lysozyme
25
peptidylarginine deiminase
23
reverse transcriptase
23
luciferase
23
beta-lactamase
22
MMP
21
neuraminidase
21
cathepsin G
20
cathepsin B
20
endonuclease
18
plasmin
18
neutrophil collagenase
17
proteinase K
16
arginine deiminase
16
phospholipase C
16
kallikrein
15
tryptase
15
MIP
14
thrombin
14
protein kinase C
14
urokinase-type plasminogen activator
13
ACS
13
sialidase
12
PAL
12
PAL
12
CAD
11
CAD
11
CAD
11
lipase
11
AMP-activated protein kinase
11
matrix metalloproteinase 9
11
glutathione peroxidase
10
MEK
10
ATPase
10
IKK
10
dipeptidyl peptidase IV
10
phosphatidylinositol 3-kinase
9
papain
9
carbonic anhydrase
9
matrix metalloproteinase 2
8
interstitial collagenase
8
NOS
7
hyaluronidase
7
RNA polymerase
7
beta-galactosidase
7
glutathione S-transferase
7
tissue plasminogen activator
7
chymotrypsin
7
sulfatase
7
DNase
7
GSK
7
gamma-glutamyl transpeptidase
7
cystathionine gamma-lyase
7
urease
7
CD10
7
NO synthase
7
PARP
6
more...
Compound
Clin
1300
Dec
849
DNA
625
TNF
348
calcium
282
oxygen
221
arginine
183
water
158
cysteine
157
glucose
153
sodium
137
phosphate
118
lysine
117
hydroxide
86
iron
84
SDS
72
acetate
69
nitric oxide
67
THP
65
THP
65
zinc
63
titanium
59
PGE
57
ClO
54
serine
54
sulfate
51
hydrogen
50
PGE2
50
His
45
alanine
44
NIDA
42
leucine
41
vitamin D
39
silver
37
MIC
37
iodine
36
ethanol
34
Phe
34
nitrogen
31
ALP
29
MTT
29
EDTA
28
EDTA
28
ATP
28
PPD
28
PPD
28
CO2
27
potassium
27
galactose
27
BOP
27
H2S
26
methionine
25
tyrosine
24
nitrate
23
bromide
21
HCl
21
hyaluronic acid
21
Minocycline
20
GSH
20
GSH
20
Collagen
20
Tetracycline
20
salt
19
Doxycycline
19
PEG
19
Chlorhexidine
17
H2O2
17
TOF
17
phenol
17
chromium
17
Amoxicillin
16
DMF
16
Gly
16
8-OHdG
15
urea
15
Vitamin D
15
Nicotine
15
aluminum
14
Alizarin
14
nickel
14
more...