Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0031099 (periodontitis)
12,489 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 766
cytokine 590
lipopolysaccharide 492
Mol 393
IL-6 389
collagen 362
TNF 348
IL-8 250
RANKL 241
tumor necrosis factor 212
LPS 174
IL-1 160
osteogenic 153
IL-10 152
TLR4 148
insulin 143
IgA 137
TLR2 132
alkaline phosphatase 116
matrix metalloproteinase 113
C-reactive protein 113
interleukin-6 112
CD4 111
IL-17 108
collagenase 108
osteoprotegerin 107
IL-1 beta 101
tumor necrosis factor alpha 90
p38 90
TNF-alpha 87
Cytokine 87
IL-4 85
hemoglobin 82
MMP-9 81
MMP-8 81
chemokine 76
IFN 72
kit 69
tartrate-resistant acid phosphatase 68
SDS 67
interferon 66
THP 65
ANOVA 63
CD14 62
fibronectin 61
RANK 61
myeloperoxidase 60
p65 58
inducible nitric oxide synthase 55
membrane protein 55
gut 54
osteocalcin 53
JNK 50
MMP-1 49
CD8 49
cathepsin C 49
TRAP 48
MAPK 48
type I collagen 48
OPG 47
GCF 47
IFN-gamma 47
Gen 46
cathepsin K 46
cyclooxygenase-2 44
COX-2 43
macrophage colony-stimulating factor 42
IL-2 42
PLS 42
MMP-2 41
CAL 41
lactoferrin 41
catalase 40
ERK 40
vascular endothelial growth factor 39
SRP 39
superoxide dismutase 39
aspartate aminotransferase 38
JP2 38
CD18 37
more...
Disease
periodontitis 12489
periodontal disease 2404
plaque 1846
gingivitis 1283
diabetes 662
tooth loss 525
rheumatoid arthritis 344
dental caries 325
juvenile periodontitis 297
infectious diseases 267
cardiovascular disease 232
cancer 214
atherosclerosis 214
osteoporosis 209
Plaque 188
type 2 diabetes 161
HIV 152
obesity 149
bacterial infection 137
Subgingival plaque 132
pulpitis 119
systemic disease 105
edentulous 103
arthritis 102
hypertension 102
stroke 93
Alzheimer's disease 81
immunodeficiency 77
AIDS 76
tumor 75
endocarditis 70
coronary heart disease 69
oral cancer 69
SDS 68
bacteremia 68
aggression 65
hyperkeratosis 63
metabolic syndrome 59
osteomyelitis 56
hyperglycemia 53
cytomegalovirus 53
Epstein 52
myocardial infarction 52
pneumonia 52
xerostomia 52
candidiasis 52
squamous cell carcinoma 51
Apical periodontitis 49
PLS 48
Infection 48
stomatitis 47
Haemophilus 47
depression 46
osteoarthritis 46
chronic disease 45
coronary artery disease 43
Alveolar bone loss 42
SEM 41
type 1 diabetes 40
asthma 37
Down syndrome 35
dental calculus 34
psoriasis 33
oral candidiasis 33
inflammatory bowel disease 32
chronic obstructive pulmonary disease 32
herpes simplex 32
Caries 31
sepsis 31
neutropenia 30
autoimmune disease 30
malnutrition 29
Crohn's disease 29
hairy leukoplakia 28
sinusitis 28
cold 27
systemic lupus erythematosus 27
Kaposi's sarcoma 27
pericoronitis 26
sepsis 26
more...
Symptom
pain 229
anesthesia 73
halitosis 54
discomfort 40
discomfort 39
erythema 30
dental pain 25
diarrhea 17
overweight 17
microbial colonization 14
angina 9
fatigue 8
anorexia 8
headache 7
distraction 7
ENT 6
weakness 6
arthralgia 6
Ill 5
paresthesia 5
Postoperative pain 5
numbness 5
analgesia 5
collapse 4
thinning 4
orofacial pain 4
respiratory distress 4
chest pain 4
agitation 3
splenomegaly 3
regurgitation 3
bone pain 3
tachypnea 3
hyperesthesia 3
acidity 3
sore throat 3
insomnia 3
back pain 3
vomiting 3
cachexia 3
disturbed balance 3
abdominal pain 3
nausea 3
pallor 2
loss of taste 2
starvation 2
scaly skin 2
sleepiness 2
facial pain 2
polyuria 2
swollen joints 2
neuralgia 2
myalgia 2
hepatosplenomegaly 2
exhaustion 2
seizures 2
hoarseness 2
acute pain 2
Wind 2
chills 2
neck pain 2
adenitis 1
apathy 1
photophobia 1
spasm 1
stomach pain 1
No adverse effect 1
Decreased activity 1
paresis 1
constipation 1
cough 1
Sulfur granules 1
neurological disability 1
DNA marker 1
nausea and vomiting 1
hopelessness 1
Fluctuation 1
enanthema 1
productive cough 1
loss of balance 1
more...
Drug
lysine 66
Dermatol 47
IFN-gamma 46
IL-2 42
citric acid 24
ascorbate 23
PDL 20
IL-1ra 20
Doxycycline 19
ROS 18
Gel 18
ampicillin 17
CSF 17
Azithromycin 14
Amoxicillin 14
Monit 13
TTC 12
Vibramycin 12
DOXY 12
Cardiovasc 12
Bifidobacterium 11
AMC 11
Augmentin 10
Augmentin 10
vitamin E 10
Heme 9
Simvastatin 9
CAM 9
lactose 9
Asthma 8
ENT 8
ABC 7
OMP 7
ROC 7
TAC 7
CTX 6
CaCl2 6
Hypaque 6
IL-11 6
CTX 6
CTX 6
CaCl2 6
CaCl2 6
Albumin 5
SnF2 5
G-CSF 5
Peridex 5
Sodium hypochlorite 5
DEL 5
Indomethacin 5
Hypaque 5
ACT 4
CCL 4
SiO2 4
NADH 4
Gelatin 4
Paraffin 4
Histamine 4
Phenytoin 4
Asn 4
Citric acid 4
FLP 4
MAP 4
DNase I 4
Dilantin 3
Zoledronic acid 3
Tinidazole 3
Triclosan 3
MINO 3
Aloe 3
EPA 3
Minocin 3
Spectrum 3
ADM 3
NBT 3
Ethanol 3
Moxifloxacin 3
Myricetin 3
Ringer's solution 3
Teriparatide 3
more...
Enzyme
collagenase 220
mitogen-activated protein kinase 180
alkaline phosphatase 117
peroxidase 90
trypsin 77
elastase 70
ERK 63
RGP 48
cathepsin K 46
catalase 44
superoxide dismutase 44
Lys-gingipain 42
cathepsin C 42
aspartate aminotransferase 41
neutrophil elastase 39
MMP-3 36
lactate dehydrogenase 35
acid phosphatase 34
beta-glucuronidase 33
focal adhesion kinase 29
caspase-1 28
caspase-3 26
protein kinase 25
lysozyme 25
peptidylarginine deiminase 23
reverse transcriptase 23
luciferase 23
beta-lactamase 22
MMP 21
neuraminidase 21
cathepsin G 20
cathepsin B 20
endonuclease 18
plasmin 18
neutrophil collagenase 17
proteinase K 16
arginine deiminase 16
phospholipase C 16
kallikrein 15
tryptase 15
MIP 14
thrombin 14
protein kinase C 14
urokinase-type plasminogen activator 13
ACS 13
sialidase 12
PAL 12
PAL 12
CAD 11
CAD 11
CAD 11
lipase 11
AMP-activated protein kinase 11
matrix metalloproteinase 9 11
glutathione peroxidase 10
MEK 10
ATPase 10
IKK 10
dipeptidyl peptidase IV 10
phosphatidylinositol 3-kinase 9
papain 9
carbonic anhydrase 9
matrix metalloproteinase 2 8
interstitial collagenase 8
NOS 7
hyaluronidase 7
RNA polymerase 7
beta-galactosidase 7
glutathione S-transferase 7
tissue plasminogen activator 7
chymotrypsin 7
sulfatase 7
DNase 7
GSK 7
gamma-glutamyl transpeptidase 7
cystathionine gamma-lyase 7
urease 7
CD10 7
NO synthase 7
PARP 6
more...
Compound
Clin 1300
Dec 849
DNA 625
TNF 348
calcium 282
oxygen 221
arginine 183
water 158
cysteine 157
glucose 153
sodium 137
phosphate 118
lysine 117
hydroxide 86
iron 84
SDS 72
acetate 69
nitric oxide 67
THP 65
THP 65
zinc 63
titanium 59
PGE 57
ClO 54
serine 54
sulfate 51
hydrogen 50
PGE2 50
His 45
alanine 44
NIDA 42
leucine 41
vitamin D 39
silver 37
MIC 37
iodine 36
ethanol 34
Phe 34
nitrogen 31
ALP 29
MTT 29
EDTA 28
EDTA 28
ATP 28
PPD 28
PPD 28
CO2 27
potassium 27
galactose 27
BOP 27
H2S 26
methionine 25
tyrosine 24
nitrate 23
bromide 21
HCl 21
hyaluronic acid 21
Minocycline 20
GSH 20
GSH 20
Collagen 20
Tetracycline 20
salt 19
Doxycycline 19
PEG 19
Chlorhexidine 17
H2O2 17
TOF 17
phenol 17
chromium 17
Amoxicillin 16
DMF 16
Gly 16
8-OHdG 15
urea 15
Vitamin D 15
Nicotine 15
aluminum 14
Alizarin 14
nickel 14
more...