Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma ) and neopterin (NPT) in 20 patients with chronic periodontitis and the control group (10 blood donors). We also investigated the difference between the mild (I group) and moderate forms (II group) of chronic periodontitis. Each group consisted of 10 patients. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay techniques. The mean serum INF-gamma level in control was 9.7+/-3.18 pg/mL. The mean serum INF-gamma level in chronic periodontitis patients (n=20) was 13.08+/-4.6 pg/mL, in the I group (n=10) it was equal to 12.09+/-4.8 pg/mL; in the II group (n=10) - 13.2+/-4.03 pg/mL. Serum levels of INF-gamma in patients with chronic periodontitis were significantly higher than those in controls (p=0,024). Significant difference was observed in serum levels of INF-gamma between patients with moderate form and control group (p=0,043). There was no significant difference in serum levels of INF-gamma between patients with mild form and the control group (p=0,11). There was no significant difference between patients from I and II groups (p=0.9). The mean serum level of NPT in the control was 5.3+/-2.39 nmol/L. The mean serum NPT level in patients (n=20) with chronic periodontitis was 11.83+/-7.5 nmol/L, in I group it was equal to 9.27+/-1.84 nmol/L; in the II group -- 14.4+/-10.05 nmol/L. Serum levels of NTP in patients with chronic periodontitis were significantly higher than those in controls (p=0.001). Significant difference was observed in serum levels of NPT between patients with mild form and control group (p=0.0006). There was significant difference in serum levels of NPT between patients with moderate form and the control group (p=0.02). There was no significant difference between patients from the I and II groups (p=0.13).
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PMID:[Interferon-gamma and neopterin in blood serum of patients with chronic periodontitis]. 1651 Sep 12

The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma) and neopterin (NPT) in 10 patients with mild form of chronic periodontitis before and after operations. Overall objective of these operations is the elimination of periodontal and osseous pockets. 10 blood donors were included in the control group. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay technique. INF-gamma and neopterin in patients with chronic periodontitis were assessed before and 4 to 6 weeks after the operation. The mean serum INF-gamma in patients with mild form of chronic periodontitis (n=10) was 13,2+/-4,03 pg/mL. The mean serum INF-gamma level in patients with mild form of chronic periodontitis (n=10) after the operations was 10,05+/-3,12 pg/mL. Serum levels of INF-gamma in patients with mild form chronic periodontitis were significantly higher than those in the control group. There was no significant difference in serum levels of INF-gamma in patients with mild form before and after operations. The mean serum level of NPT in the control was 5,3+/-2,39 nmol/L. The mean serum NPT level in patients (n=10) with mild form chronic parodontitis was 14,4+/-10,05 nmol/L. After operations NPT concentration were reduced (6,9+/-3,39 nmol/L). Serum levels of NTP in patients with mild form chronic periodontitis were significantly higher than those in the control group. Significant difference was observed in serum levels of NPT in patients with mild form of chronic periodontitis before and after operations. Obtained data allow specifying the mechanism of positive influence of autograft operations on the pathogenesis of chronic periodontitis.
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PMID:[Interferon-gamma and neopterin in blood serum of patients with chronic periodontitis after autograft operations]. 1663 74