Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors
P2X5
and P2X7 have both been implicated in bone biology, and it has been suggested recently that
P2X5
may be a significant regulator of inflammatory bone loss. However, a role for
P2X5
in
periodontitis
is unknown. The present study aimed to evaluate the functional role of
P2X5
in ligatureinduced
periodontitis
in mice. Five days after placement of ligature, analysis of alveolar bone revealed decreased bone loss in P2rx5-/- mice compared to P2rx7-/- and WT control mice. Gene expression analysis of the gingival tissue of ligated mice showed that IL1b, IL6, IL17a and Tnfsf11 expression levels were significantly reduced in P2rx5-/- compared to WT mice. These results suggest the
P2X5
receptor may regulate bone loss related to
periodontitis
and it may thus be a novel therapeutic target in this oral disease. [BMB Reports 2018; 51(9): 468-473].
...
PMID:The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis. 3010 45
