Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A number of recent studies have shown dysregulation of some long non-coding RNAs (lncRNAs) in affected tissues or peripheral blood of patients with
periodontitis
. In the current study, we investigated the role of
TNF and
HNRNPL
related immunoregulatory
(
THRIL
) and
p50-associated COX-2 extragenic RNA
(
PACER
) lncRNAs in
periodontitis
. We assessed expression of these lncRNAs in 30 affected tissue, 30 control tissue samples, 23 blood samples from patients and 18 blood samples from healthy controls. Expression of
PACER
was higher in total blood samples of patients compared with controls (Posterior beta of RE = 5.143, P value = 0.001). However, when assessing its expression in a gender-based manner, the difference in the expression of this lncRNA was significant only among male subgroups (Posterior beta of RE = 7.16, P value < 0.0001). Moreover, expression of
PACER
was significantly higher in female subjects compared with male subjects (Posterior beta of RE = 3.098, P value < 0.0001). There was no significant difference in tissue expression of
PACER
between study subgroups. Expression of
THRIL
was not significantly different between blood/tissue samples of cases and controls. However, expression of this lncRNA was higher in blood of female subjects compared with male subjects (Posterior beta of RE = 4.353, P value = 0.002). Tissue expression of
THRIL
was correlated with blood levels of this lncRNA (r = 0.33, P < 0.0001) and with the tissue levels of
PACER
(r = 0.3, P < 0.0001). Moreover, blood levels of these lncRNAs were correlated with each other (r = 0.34, P < 0.0001). However, there was no significant correlation between blood and tissue levels of
PACER
. Expression of these lncRNAs were not correlated with age either in males or in females. Taken together, we demonstrated a sex-based up-regulation of
PACER
in blood samples of patients with
periodontitis
which implies possible participation of this lncRNA in the pathobiology of
periodontitis
.
...
PMID:Sex-specific up-regulation of
p50-associated COX-2 extragenic RNA
(
PACER
) lncRNA in periodontitis. 3242 38
