Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ketorolac tromethamine gel (KT gel) and ketorolac tromethamine gel containing genipin (
KTG
gel) were prepared and their therapeutic effects on
periodontitis
were evaluated. The skin permeation rate of ketorolac from the KT gel and
KTG
gel was 5.75+/-0.53 and 5.82 +/- 0.74 microg/cm2/ h, respectively. The skin permeation rate of genipin from the
KTG
gel was 10.13 +/- 1.47 microg/ cm2/h. The tensile strength of the
KTG
gel was larger than the KT gel. After 4 weeks, the periodontal pocket depth of the
KTG
gel group (3.22 +/- 0.20 mm) significantly decreased compared with the non-treated group (4.50 +/- 0.25 mm) and the KT group (3.84 +/- 00.26 mm). The
KTG
gel did not induce separation of the stratum corneum and subcutaneous tissue, and the collagen layers of the corium were closer, more fibrous, and showed longer connections than in the other groups. The
KTG
gel appears to be effective against gingivitis in the periodontal pocket through its increased anti-inflammatory activity and the crosslinking of genipin with the biological tissue.
...
PMID:Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases. 1770 40
