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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathological lining epithelium of destructive periodontitis was studied by analysis of the expression of intermediate filament proteins in biopsies of untreated advanced periodontitis. The cytokeratin (CK) pair 8/18 characteristic of simple epithelia was expressed consistently in a distribution pattern confined to the reactive pocket epithelium. The pattern of CK8/18 expression was complex with two broad presentations evident. In two-thirds of the advanced disease biopsies, the entire pathological lining epithelium was strongly reactive for both CK8 and CK18. In the remainder, the more superficial lining epithelium was mixed with foci of reactive and unreactive cells, with the deeper epithelium uniformly reactive. Only occasional highly localised reactivity for the simple keratins (CK8/18) was found in the lining epithelia of biopsies from minimally inflamed periodontal tissues. The pathological lining epithelium of advanced periodontitis was further characterised by the co-expression in basal layers of CK14, and of CK13 but not CK4, which are characteristic of suprabasal layers of stratified squamous epithelia. Cytokeratin 17, a marker of high turnover and migrating epithelial cells was extremely variable with no clear association between expression pattern and location of the epithelium ordisease status. There was no reactivity for CK10/11 typical of cornifying cells nor of vimentin, the characteristic intermediate filament of mesenchymal cells. The intermediate filament protein profile of the reactive lining epithelium was indistinguishable from the reactive epithelium present in three of five biopsies of periapical granulomas containing hyperplastic epithelium from activation of the developmental remnants of Hertwig's sheath, known as the cell rests of Malassez. The data reported are compatible with a contribution by remnants of developmental epithelium, including the reduced enamel epithelium and the cell rests of Malassez, to the reactive lining epithelium of the subgingival pocket in the pathogenesis of chronic periodontitis.
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PMID:Reactive pocket epithelium in untreated chronic periodontal disease: possible derivation from developmental remnants of the enamel organ and root sheath. 1127 33

In children aged 11-15. under mild and moderate stage parodontitis the ultrastracture and Citokeratines 10/13 and 14 expression in epithelial lining of oral mucosa were analyzed: 1. in gingival epithelia 2. in alveolar processes epithelia. 14 cases without sings of inflammation serve as control tissue. Total number of cases - 33. After informed consent had been obtained, simples of histological tissue specimens were collected on surgical extraction of the tooth. In the control group decision on the tooth extraction was taken for the orthodontic causes. Our data indicate that: 1. Heterogenity is typical to the oral cavity epithelium: a) Ultrastructural signs of keratinization and dissociation, with typical high activity of the terminal differentiation marker cytokeratin 10/13, predominate in the keratinocytes of gingival mucosa. b) Cells with signs of germination activity predominate in the ultrastructure of mucosa alveolar processes. Such cells express cytokeratin 14, typical to nonkeratinized epithelium. 2. Tissue architectonics as well as protein contents of cytoskeleton (judging by cytokeratine expression) are speared in the parodontal pathology in children, however in contrast to alveolar mucosa, damage to the microcirculatory vessels is more pronounced in gingival mucosa. 3. Expression of cytokeratines 10/13 and 14 may indicate the process of lysis and reparation of periodontal ligament.
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PMID:Ultrastructural and molecular-biological features of inflammatory-destructive processes in pathology of parodontal complex in children. 1955 48