Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In recent years, the concept of distinct subpopulations of human neutrophils has attracted much attention. One bona fide subset marker, exclusively expressed by a proportion of circulating neutrophils in a given individual, and therefore dividing neutrophils in two distinct subpopulations, is the glycoprotein
CD177
.
CD177
is expressed on the plasma and granule membranes of 0-100% of circulating neutrophils depending on the donor. Several in vitro studies have linked
CD177
to neutrophil transmigration, yet very few have looked at the role of
CD177
for tissue recruitment in vivo. We investigate whether the
CD177
+
and
CD177
-
neutrophil subsets differ in their propensity to migrate to both aseptic- and microbe-triggered inflamed human tissues. Microbe-triggered neutrophil migration was evaluated in samples of gingival crevicular fluid (GCF) from patients with
periodontitis
, whereas neutrophil migration to aseptic inflammation was evaluated in synovial fluid from patients with inflammatory arthritis, as well as in exudate from experimental skin chambers applied on healthy donors. We found that the proportion of
CD177
+
neutrophils was significantly higher in GCF from patients with
periodontitis
, as compared to blood from the same individuals. Such accumulation of
CD177
+
neutrophils was not seen in the two models of aseptic inflammation. Moreover, the proportion of
CD177
+
neutrophils in circulation was significantly higher in the
periodontitis
patient group, as compared to healthy donors. Our data indicate that the
CD177
+
neutrophil subset is preferentially recruited to the gingival crevice of
periodontitis
patients, and may imply that this subtype is of particular importance for situations of microbe-driven inflammation.
...
PMID:The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis. 3253 26
