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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polypeptide growth factors are a class of potent natural biologic mediators which regulate many of the activities of wound healing including cell proliferation, migration and metabolism. Periodontal regeneration is thought to require the migration and proliferation of periodontal ligament cells on the root surface. In fact, repopulation of the detached root surface by cells from periodontal ligament (PDL) is a prerequisite for new attachment formation. Many studies suggested that Polypeptide Growth Factors (PGF) such as Insulin-like Growth Factor I (IGF-I), Platelet Derived Growth Factor (PDGF), Transforming Growth Factor B (TGF-B), Epidermal Growth Factor (EGF), are important mediators of cellular events in wound healing. Studies in vitro analysed the mitogenic effects determined on periodontal ligament cells by growth factors using (3H) Thymidine incorporation during DNA synthesis. The results suggested that recombinant human PDGF and IGF-I stimulate the proliferation of PDL fibroblastic cells and the combination of these growth factors showed a synergistic effect revealing the highest mitogenic effect among all individual growth factors as well as any combination of the growth factors tested. Furthermore these studies demonstrated that rh-PDGF and IGF-I stimulate chemotaxis of PDL fibroblastic cells, and supported a role for TGF-B as a regulator of the mitogenic response to PDGF in these cells. Other studies in vivo showed periodontal tissues regeneration introducing mixtures of recombinant human platelet derived growth factor and insulin-like growth factor into lesions of experimentally induced periodontitis in beagle dogs and monkeys.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Periodontal regeneration: the use of polypeptide growth factors]. 770 Feb 21

The influence of alkaline polypeptides-cytomedines on the level of free radical oxidation of lipids, hemocoagulant, fibrinolytic and aggregative properties of erythrocytes in spontaneous parodontitis has been investigated. It has been established that the development of spontaneous parodontitis is accompanied by the activation of peroxide oxidation of cellular membranes, which results in the development of hypercoagulation and inhibition of fibrinolytic properties of erythrocytes, thereby intensifying the state of microcirculatory hemostasis. Polypeptide of the parodontium a modulating effect on the state of free-radical oxidation, improves antioxidant status of blood cells, stabilizes indices of erythrocytic link of hemostasis. The investigated cytomedines may be promising for treatment of the parodontium pathology.
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PMID:[Effect of paradentium polypeptide on the lipid peroxidation of the membranes and coagulation of erythrocytes in rats with spontaneous paradentitis]. 775 11

Polypeptide growth and differentiation factors (GDFs) are a class of biological mediators which have been shown to play a critical role in the stimulation and regulation of the wound healing process. Growth factors involved in repair and regeneration regulate several key cellular processes such as mitogenesis, chemotaxis, differentiation, and metabolism. The sequence of events necessary for periodontal regeneration relies on the above processes for osteogenesis, cementogenesis, and connective tissue formation. Numerous preclinical in vitro and in vivo studies have demonstrated that certain growth factors modulate putative components of periodontal wound healing resulting in substantial regeneration of the periodontium in animals. However, these therapies are currently considered to be in the experimental stage of development and no growth factor therapy to treat periodontitis in humans has received approval by the Food and Drug Administration (FDA). This informational paper reviews the various aspects of GDFs on cells and tissues involved in periodontal wound healing. This paper was prepared by the Committee on Research, Science and Therapy of The American Academy of Periodontology and is intended for members of the dental profession.
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PMID:The potential role of growth and differentiation factors in periodontal regeneration. 1766 65