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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the present clinical study was to evaluate the healing of deep intrabony defects following the application of an oily calcium hydroxide suspension (OCHS). Thirty patients suffering from chronic periodontitis, each of whom displayed one intrabony defect, were randomly treated with access flap surgery (AFS) and the application of OCHS (test) or with AFS alone (control). The following clinical parameters were recorded at baseline and at 6 months after therapy: plaque index, gingival index, bleeding on probing, probing depth (PD), gingival recession, and clinical attachment level (CAL). No differences in any of the investigated parameters were observed at baseline between the two groups. At 6 months after therapy, the test group showed a reduction in mean PD from 7.7+/-1.5 to 2.9+/-0.9 mm (P<0.001) and a change in mean CAL from 9.6+/-2.1 to 5.5+/-2.5 mm (P<0.001). In the control group, the mean PD was reduced from 6.9+/-0.9 to 3.7+/-0.9 mm (P<0.001) and the mean CAL changed from 8.5+/-2.5 to 6.4+/-2.7 mm (P<0.001). OCHS resulted in statistically significant higher PD reductions (P<0.01) and CAL gains (P<0.05) than AFS alone. Within the limits of the present study, it can be concluded that: (1) at 6 months after surgery both therapies resulted in statistically significant PD reductions and CAL gains and (2) treatment with OCHS resulted in statistically significant higher CAL gains than treatment with AFS alone.
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PMID:Healing of intrabony defects following treatment with an oily calcium hydroxide suspension (Osteoinductal). A controlled clinical study. 1636 21

The purpose of the present study was to evaluate clinically the effect of an oily calcium hydroxide suspension on early wound healing after nonsurgical periodontal therapy. A total of 19 patients with chronic periodontitis were enrolled in the study. Each subject had three sites in each of two contra-lateral jaw quadrants with a probing pocket depth (PPD) of > or =5 mm and bleeding on probing (BoP+). All teeth received scaling and root planing under local anesthesia followed by irrigation with sterile saline. An oily calcium hydroxide suspension (Osteoinductal) was applied subgingivally to the test sites at random. All sites were reexamined after 1, 2 [gingival index (GI) and BoP], and 3 weeks (GI, BoP, and PPD). Treatment success was defined as no signs of GI (GI=0), no BoP (BoP-), and pocket closure (PPD< or =4 mm). At all three different points in time, there were improvements in both GI and BoP at the control and test sites, which were in favor of the test therapy (p<0.05). For PPD change, no differences were found between the test and the control sites. The results of the study suggest that the topical application of an oily calcium hydroxide suspension (Osteoinductal), after nonsurgical periodontal therapy, improves early periodontal wound healing.
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PMID:Effect of an oily calcium hydroxide suspension on early wound healing after nonsurgical periodontal therapy. 1640 29

The study was aimed at comparing the efficacy of disinfection of root canals with periapical radiolucencies when treated with either antibiotics/steroid medicaments (Ledermix or Septomixine) or a calcium hydroxide paste (Calasept). Microbiological samples were taken before and after two-visit endodontic treatment from 88 canals with apical periodontitis. All of the canals but one (87 of 88) had cultivable growth before treatment. After dressing with Ledermix, Septomixine, or Calasept, the percentages of canals remained with positive growth were 48% (13 of 27), 31% (8 of 26), and 31% (11 of 35), respectively. The chi(2) tests showed there were no significant differences in the number of canals with positive growth or mean colony forming units counts after instrumentation, irrigation and dressing. In the Ledermix group, 38 strains of bacteria were recovered. The Septomixine group had 25 strains, and the Calasept group had 25 strains. Gram-positive facultative anaerobic cocci (including staphylococci and streptococci) were more prevalent than the Gram-negative obligate anaerobic rods after treatment in all three groups. Similarities in the reduced number of canals with residual growth, and the prevalence of Gram-positive facultative anaerobic cocci suggest that the use of different inter-appointment dressings produced similar microbiological outcomes. However, factors other than the antimicrobial effectiveness of intracanal medicaments may also be responsible for the results observed.
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PMID:Identification of cultivable microorganisms from root canals with apical periodontitis following two-visit endodontic treatment with antibiotics/steroid or calcium hydroxide dressings. 1641 62

Periodontal disease is caused by infections with oral periodontitis-associated microorganisms. Virulence factors like lipopolysaccharide (LPS) from those microorganisms initiate host immune response and gingival chronic inflammation. As a result, elevated receptor activator of NF-kappaB ligand (RANKL) expression stimulates alveolar bone resorption followed by loss of teeth.
Clin Calcium 2006 Feb
PMID:[The mechanism of bone resorption in chronic inflammation of periodontal disease]. 1646 25

Periodontitis is a chronic inflammatory disease caused by infection of periodontopathic bacteriae, which induces alveolar bone resorption, tooth mobility, and finally tooth loss. In order to clarify the pathogenesis and to develop prevention and treatment of periodontitis, it is important to establish animal models of periodontitis. In this article, we showed several types of experimental models previously reported, and also showed a rat model using ligature and a hamster model using periodontopathic bacteria, both we used in our laboratory. Micro computed tomography (CT) analysis and histological observation revealed the inflammatory localization and osteoclast appearance in periodontal tissues. The usefulness of animal models of periodontitis is demonstrated by exhibiting an inhibitory effect of bisphosphonate and prostaglandin E(2) on alveolar bone resorption in our experimental systems.
Clin Calcium 2006 Feb
PMID:[Alveolar bone resorption in animal models of periodontitis]. 1646 26

Periodontitis is an inflammatory disease which is involved with gingival attachment loss and an alveolar bone resorption. Traditional methods for taking X-ray photograph or assessments of probing depth and clinical attachment level are provided the previous periodontal tissue breakdown, however, these methods are hard to confirm the disease activity and predict of the disease outcome. Therefore, the component or quality of gingival crevicular fluid (GCF), which is directly, reflects the gingival inflammation is noticed. It firstly describes that GCF containing the inflammatory mediator, cytokine, and bone markers are not only related to the bone resorption but also affected the periodontal disease activity. As the final part in the series it lastly discusses the possible uses of predictive diagnostic tests of periodontal disease activity in dental practice.
Clin Calcium 2006 Feb
PMID:[Periodontal examination for alveolar bone resorption]. 1646 27

Many studies have attempted to define the relationship between postmenopausal osteoporosis and periodontal disease. Most studies support a positive association between these common diseases; however, many are cross-sectional in nature, include relatively small sample sizes, and have inadequate control of potential confounding factors, such as age, gender, hormone intake, race, and smoking, limiting our understanding of the nature of the relationship between these diseases. Clinical conditions causing low estrogen environments in postmenopausal women allow T- and B-cell abnormalities, increased local production of the bone-active cytokines (i.e., Interleukin-1, -6 and -8, tumor necrosis factor [TNF]-alpha) and a rise in prostaglandin E(2), resulting in the progression of periodontitis.
Clin Calcium 2006 Feb
PMID:[Osteoporosis and periodontal disease in postmenopausal women: association and mechanisms]. 1646 29

Osteoporosis is suspected as a potential risk factor in periodontal disease. However, the detailed relationship between these diseases is unclear. The particular models of laboratory animals for the both diseases are needed to clarify the interactive influence route. In this article, we introduce the animal models for both diseases, review the relationship between osteoporosis and periodontal disease in animals and report our laboratory study. The purpose of our study was to investigate the effect of an ovariectomy on the progression of experimental periodontitis in rats. Thirty female Sprague-Dawley rats as control, 30 sham-operated rats and 30 ovariectomized rats (OVX group) were included. In the maxillary molars of every rat, a nylon thread was ligated to induce experimental periodontitis. The results were as follows : at 6 and 12 weeks in the OVX group, the levels of bone mineral density (BMD) had decreased more significantly. The periodontal tissues in the OVX group showed a severer inflammation and alveolar bone resorption. From these results, it is suggested that the osteoporotic conditions may affect the progression of periodontal lesions in rats. It will be necessary to clarify with a molecular mechanism with the establishment of animal models in both diseases in the future.
Clin Calcium 2006 Feb
PMID:[The relationship between periodontal disease and osteoporosis in animals]. 1646 30

Periodontitis is considered to be a common disease which onset and progression seems to be associated with genetic factors and many environmental factors, especially, the amount and composition of bacterial plaque. Previous studies have shown an association between periodontitis and polymorphisms in some genes, however, the critical loci for periodontal disease have not yet been identified. In the future, whole-genome association studies with periodontitis would suggest that the genetic susceptibility loci for periodontitis and provides important information for elucidation of the molecular mechanisms involved in the etiology of periodontal disease.
Clin Calcium 2006 Feb
PMID:[Searches for the genes associated with periodontitis with gene polymorphisms]. 1646 34

Bisphosphonates are known as highly effective inhibitors of osteoclastic bone resorption that selectively affect osteoclasts. They are world-wildly used for the treatment of metabolic bone diseases with excessive bone resorption such as osteoporosis and Paget's disease. Alveolar bone loss in periodontitis results from local inflammatory reactions by periodontopathic bacteria. It has been reported that bisphosphonates efficiently prevent experimentally induced alveolar bone resorption in animals with periodontitis, and that bisphosphonate therapy improves the outcome of periodontal treatment in human being. Administration of bisphosphonates may be an appropriate adjunctive treatment to preserve periodontal bone mass. Further studies are needed regarding topical drug delivery system, effective dose and frequency of administration, possible side effects, and which bisphosphonate is suitable for periodontitis.
Clin Calcium 2006 Feb
PMID:[Application of bisphosphonates for periodontitis]. 1646 39


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