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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dogs' teeth with apical periodontitis were treated endodontically, Dakin's solution being used in an experimental group as the irrigation solution, and camphorated paramonochlorophenol as an intracanal dressing. For a second group of teeth, the irrigation solution used was physiologic saline, dry cotton only being placed into the pulpal chamber to take the place of an intracanal dressing. In a second visit, overinstrumentation and a new application of the same kind of dressing were performed, the root canals being then filled with gutta-percha cones and zinc oxide-eugenol cement. Other specimens were treated, in one visit, where physiologic saline or Dakin's solution were the irrigation solutions. The animals were sacrificed 6 months after the obturation of the root canals. Histologic exams showed better results for the experimental group where Dakin's solution and camphorated paramonochlorophenol had been used, with signs of repair characterized by newly formed cementum and bone tissue, as well as a marked reduction in size of the periapical lesions. No differences were seen in the results with physiologic saline or Dakin's solution as irrigants.
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PMID:Influence of irrigation and intracanal dressing on the healing process of dogs' teeth with apical periodontitis. 130 85

Fourteen male patients with periodontitis and 10 patients free of periodontitis were included in the study. The concentrations of testosterone (T), calcium (Ca), magnesium (Mg), and zinc (Zn) were measured in serum and parotid saliva. Patients with periodontitis had increased Ca and decreased Zn serum levels, and they had decreased Ca and increased T levels in parotid saliva. Furthermore, there was a low correlation between parotid saliva T and Mg levels in the patients with periodontitis (r = 0.61, n = 14, t = 2.663, p less than 0.005), and there is an inverse relationship between serum and parotid saliva Mg levels (r = - 0.58, n = 14, t = 2.468, p less than 0.05).
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PMID:Serum and parotid saliva testosterone, calcium, magnesium, and zinc levels in males, with and without periodontitis. 172 75

Matrix metalloproteinases are an important group of zinc enzymes responsible for degradation of the extracellular matrix components such as collagen and proteoglycans in normal embryogenesis and remodeling and in many disease processes such as arthritis, cancer, periodontitis, and osteoporosis. A matrixin family is defined, comprising at least seven members that range in size from Mr 28,000 to 92,000 and are related in gene sequence to collagenase. All family members are secreted as zymogens that lose peptides of about 10,000 daltons upon activation. Latency is due to a conserved cysteine that binds to zinc at the active center. Latency is overcome by physical (chaotropic agents), chemical (HOCl, mercurials), and enzymatic (trypsin, plasmin) treatments that separate the cysteine residue from the zinc. Expression of the metalloproteinases is switched on by a variety of agents acting through regulatory elements of the gene, particularly the AP-1 binding site. A family of protein inhibitors of Mr 28,500 or less binds strongly and stoichiometrically in noncovalent fashion to inhibit members of the family. The serum protein alpha 2-macroglobulin and relatives are also strongly inhibitory.
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PMID:Matrix metalloproteinases and their inhibitors in connective tissue remodeling. 185 Jul 5

.1% solution of native terrilytin, a proteolytic enzyme, and 5% profezyme, an immobilized enzyme, were used in the treatment of periodontal inflammations. To enhance the efficacy of enzyme therapy, the latter agent was combined with an antiseptic and pyrimidine-based methychlozyme paste including 5% of profezyme, 0.2% of chlorohexidine bigluconate, 0.2% of methyluracil, 30% of glycerin, and zinc oxide 74.6%. Use of immobilized and native proteolytic enzymes in therapy of patients with gingivitis and periodontitis permitted reducing the number of sessions 1.5-fold. Multiple-modality treatment was conducive to prolongation of the process remission up to 2 years in 52.31% of patients whereas in conventional therapy such remissions could be achieved in only 20%.
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PMID:[The use of immobilized and native proteolytic enzymes in treating inflammatory periodontal diseases]. 220 83

The oral spirochete, Treponema denticola is a putative etiologic agent in adult periodontitis, and acute necrotizing ulcerative gingivitis. In vitro, the oral treponeme produces several factors including proteases, hemolysins, hemin-binding proteins, which could potentially be involved in the virulence of this spirochete. Our laboratory has been investigating the pathobiology of T. denticola, and has demonstrated the production of several hemolysins by T. denticola. In this report two hemolysin genes from T. denticola strains ATCC 35404 (TD-4) and GM-1 were isolated by screening genomic DNA libraries of T. denticola on sheep blood agar plates. Physical maps of the insert fragments were not identical. Southern blot analyses suggested some degree of homology in the nucleotide sequence. Maxicell analyses of [35S]-methionine-labeled polypeptides from the recombinant plasmids have suggested the synthesis of an approximately 62.5 kDa polypeptide. Biochemical characterization of the T. denticola hemolysin genes indicated the activity to be inhibited by Mg2+, Ca2+ and Zn2+ but not by EDTA. Dithiothreitol and glutathione moderately enhanced the hemolytic activity of the recombinant plasmids. Iron partially inhibited the hemolytic activities. Addition of 2-2' bipyridyl moderately enhanced the activities, possibly by iron limitation. These results suggest the isolation of an identical hemolysin gene from T. denticola strains TD-4 and GM-1.
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PMID:Cloning and expression of hemolysin genes from Treponema denticola strains ATCC 35404 (TD-4) and human clinical isolate GM-1 in Escherichia coli. 781 17

The effects of different intracanal medicaments and zinc oxide-eugenol based root canal sealers on an experimentally induced apical periodontitis were studied histologically in mesial roots of lower molars of Wistar rats. After root canal instrumentation each canal was filled either with an intracanal medicament twice for 3 days each time or with a sealer for 21 days. The intracanal medicament chlorophenol caused periapical tissue damage. P-chloroxylenol-camphor lead to periapical improvement as did 5% sodium-hypochlorite. 12% sodium-hypochlorite gave tissue damage. After intracanal medication with an aqueous suspension of calcium hydroxide periapical repair was clearly visible. A combination of a corticoid and an antibiotic appeared to induce damage of the periapical tissues. The root canal sealers Endomethasone and N2 essentially impaired periapical repair. The results were acceptable for Aptal-Zink-Harz root canal fillings after 21 days as well as after 56 days.
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PMID:Reaction of inflamed periapical tissue to intracanal medicaments and root canal sealers. 784 66

The purpose of this study was to determine the effect of daily water irrigation versus regular oral hygiene alone on gingival and periodontal health in periodontitis patients receiving supportive periodontal treatment. The study also sought to determine if there are enhanced benefits from using an antiplaque zinc sulfate rinse as an irrigant. One hundred fifty-five patients who have had periodontitis and had been treated either surgically or non-surgically completed the 6-month multi-center multi-national study. Patients with at least two 5 mm sites demonstrating bleeding on probing were assigned to 3 equal groups by balanced randomization. In all centers Group A (n = 57) performed regular oral hygiene only, and Group B (n = 58) irrigated with 500 ml water once daily after regular oral hygiene. Group C (n = 40) patients irrigated with a total of 500 ml once daily; following irrigation with 300 ml water, the patients then irrigated with an additional 200 ml with a zinc sulfate solution. The irrigants were diluted to provide the manufacturer's recommended daily dosage. The supragingival irrigation was performed with a commercially available oral irrigator. Bacterial measurements at baseline, 3 months, and 6 months were taken to determine the effect of irrigation on the target organisms and will be reported elsewhere. Gingival index: irrigation with water (Group B) was significantly better than normal oral hygiene (Group A) and irrigation with zinc sulfate (Group C) (P < 0.05) in reducing gingival inflammation. Bleeding on probing: significant reductions in bleeding on probing occurred for water (Group B) compared to normal oral hygiene (Group A) (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effectiveness of adjunctive irrigation in early periodontitis: multi-center evaluation. 816 16

The levels of 21 chemical elements (N, Na, Mg, P, Cl, K, Ca, Sr, Cr, Mn, Fe, Co, Zn, Se, Br, Rb, Sc, Ag, Sb, Hg) were measured in mixed unstimulated saliva of 50 patients with periodontal diseases (29 women and 21 men) aged 20 to 49 without concomitant diseases, five of these with gingivitis and the rest with generalized periodontitis of medium severity (27 cases) and grave (n = 18). A control group consisted of 52 healthy subjects with intact periodontium and teeth. A complex of instrumental methods has been developed and used in this study including neutron activation analysis (NAA) in two modifications and roentgen-fluorescent analysis. Changes in salivary levels of chemical elements were detected in the patients, these changes augmenting with severity of periodontal tissue involvement. In grave condition the concentrations of the major electrolytes were increased by 2.3 to 6.6 times on an average, of nitrogen twofold, of scandium, manganese, and chromium by 6.8-8.8 times, and of iron, cobalt, copper, selenium, bromine, silver, and mercury by 1.6-1.9 times; zinc level in mixed salivary protein reduced as the disease augmented in severity and in a grave form was only 62% of its normal content (p < 0.01). Salivary oversaturation with ions including Ca2+ which are conductive to salivary glycoprotein sedimentation and eventually to formation of a nutrient medium for pathogenic bacteria and zinc deficit indirectly indicating a reduced level of immunity status of the body are additional factors responsible for increased rate of dental deposit formation in periodontal diseases.
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PMID:[The chemical element content of mixed unstimulated saliva in periodontal diseases]. 819 35

For the treatment of patients with chronic and exacerbated periodontitis trichopol and lincomycin were used as well-known effective antibacterial drugs in anaerobic non-clostridial infection. Zinc-eugenol paste was added. The results were favourable.
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PMID:[The modern approach to the treatment of periodontitis]. 819 12

The study is to explore the possible relationship between the level of trace element zinc in serum and periodontitis with Kidney deficiency. The level of serum zinc in 40 cases of periodontitis and in 19 normal controls was examined by atomic absorption spectrum analysis. The results indicated that there was only a descending trend of serum zinc in periodontitis group as compared with normal group. But further analysis revealed that according to the severity of periodontitis and the theory of Syndrome differentiation in TCM, it showed that the drop of serum zinc had not only a negative correlation with the severity of periodontitis, but also was co-related to whether there was Kidney deficiency or not. Serum zinc of periodontitis with Kidney Deficiency group was significantly lower than that of normal control group as well as the group of periodontitis without Kidney deficiency (P < 0.05). The data suggested that the decline of serum zinc level is closely related to the occurring and development of periodontitis with Kidney Deficiency.
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PMID:[Changes in serum zinc level of periodontitis with kidney deficiency]. 831 98


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