Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
People with Parkinson's Disease (PD) are associated with the presence of
periodontitis
. We aimed to compare blood and standard biochemical surrogates of PD patients diagnosed with
periodontitis
with PD individuals without
periodontitis
. This retrospective cohort study used a sample from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 that underwent periodontal diagnosis (
n
= 3669). PD participants were identified through specific PD reported medications.
Periodontitis
was defined according to the 2012 case definition, using periodontal examination data provided. Then, we compared blood levels and standard chemical laboratory profiles of PD patients according to the presence of
periodontitis
. Multivariable regression was used to explore this dataset and identify relevant variables towards the presence of
periodontitis
. According to the medication report, 37 participants were eligible, 29 were secure and 8 were unsecure PD medications regimens. Overall, PD cases with
periodontitis
presented increased levels of White Blood Cells (WBC) (
p
= 0.002), Basophils (
p
= 0.045) and Segmented neutrophils (
p
= 0.009), and also, lower levels of Total
Bilirubin
(
p
= 0.018). In the PD secure medication group, a significant difference was found for WBC (
p
= 0.002) and Segmented neutrophils (
p
= 0.002) for the
periodontitis
group. Further, WBC might be a discriminating factor towards
periodontitis
in the global sample. In the secure PD medication, we found gender, segmented neutrophils and Vitamin D2 to be potential discriminative variables towards
periodontitis
. Thus,
periodontitis
showed association with leukocyte levels alterations in PD patients, and therefore with potential systemic changes and predictive value. Furthermore, Vitamin D2 and gender showed to be associated with
periodontitis
in with secure medication for PD. Future studies should assess in more detail the potential systemic repercussion of the presence of
periodontitis
in PD patients.
...
PMID:Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson's Disease Patients: Data from the NHANES 2011-2012. 3272 93
