Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to compare the distribution of plasma cells within the soft tissue walls of interdental deep pockets from patients with adult (AP) and juvenile/post-juvenile (JP/PJP) periodontitis. Biopsies from 20 patients and 3 control volunteers were examined: 5 with treated AP, 5 with untreated AP, 5 with treated JP/PJP and 5 with untreated JP/PJP. No plasma cells were seen within the epithelium from any of the biopsies examined, and they were very sparse within the connective tissue from the control specimens. In all the pathological specimens examined there was marked tissue destruction. The percentage density of plasma cells tended to be statistically significantly higher in JP/PJP than in AP, and in untreated than in treated lesions. The statistical analysis showed also that plasma cells were more abundant in a layer deep to the neutrophils lining the basement membrane. Plasma cells were also more abundant in areas of extensive histological inflammation. The plasma cells were often degenerate and such degeneration appeared more evident in JP/PJP and in areas of connective tissue devoid of vascular tissue. These findings appear to indicate an association between increase of collagen destruction and increase in plasma cell percentage density. This may relate in turn to an increase in penetration and/or virulence of components of the subgingival plaque following an increase in tissue permeability. The scarcity of Russell bodies within the plasma cells would suggest that immunoglobulin production and secretion are normal.
J Parodontol 1989 Sep
PMID:[Aspects of distribution of plasma cells at the advancing front of the lesion in chronic periodontitis: a quantitative ultrastructural study]. 263 91

Sonicated whole cell extracts and outer membrane proteins (OMP) from Bacteroides gingivalis and Veillonella parvula were analysed by the immunoblot technique using sera from 103 patients with various forms of periodontal disease and from 31 control subjects. B. gingivalis sonicate contained 12 major bands (75-14 kDa) of which the 46, 27 and 14 kDa antigens reacted more frequently with sera from adult and young adult patients with severe periodontitis compared with sera from controls and mild periodontitis patients. The OMP of B. gingivalis contained 6 main antigens of 75, 57, 51, 46, 35 and 19 kDa m.w. The 46 kDa antigen reacted predominantly with sera from both groups of patients with severe periodontitis. V. parvula sonicate contained 11 antigens (76-13 kDa) of which the 76 kDa antigen reacted more frequently with sera from controls and patients with mild periodontitis than with sera from patients with severe periodontitis. Conversely, antibodies to the 39 kDa antigen (absent from OMP) were specifically associated with severe periodontitis. Further monitoring of antibody responses to the 46, 27 and 14 kDa antigens of B. gingivalis and 39 kDa antigen of V. parvula may be of importance for the assessment of severity of human periodontal disease.
Oral Microbiol Immunol 1989 Sep
PMID:Detection of immunodominant antigens of periodontopathic bacteria in human periodontal disease. 263

The use of saliva as a source of components that may identify subjects at risk of developing destructive periodontitis, or provide markers of disease potential or activity, has been reviewed. It was concluded that bacteria, their constituents or products are unlikely to be rewarding and that host-derived salivary factors such as enzymes cannot identify risk, as deficiency states for these do not exist. Secretory IgA, plasma IgA and IgG isotype levels and specific antibodies may be associated with risk, but probably only if levels fall below those which are protective or a specific antibody response is absent. More work is needed to distinguish between monomeric and dimeric IgA antibodies and to identify IgG antibodies in longitudinal clinical studies. In general, although saliva may prove to be useful as a source of indicators of current disease activity or as a means of assessing responses to treatment, it is unlikely to provide evidence for the existence of risk factors.
J Clin Periodontol 1989 Sep
PMID:Detection of high-risk groups and individuals for periodontal diseases: laboratory markers from analysis of saliva. 267 4

The treatment of human periodontal diseases relies on mechanical and antimicrobial suppression of the etiologic bacteria. The ability to alter the progression of periodontitis by additionally blocking host pathways involved in the destructive process is an area of current research. Prostaglandins and other metabolites of arachidonic acid are believed to be important host mediators of the bone resorption of diseases such as periodontitis. We have previously examined the effect of inhibitors of prostaglandin production, non-steroidal anti-inflammatory drugs (NSAIDs), on inhibiting alveolar bone loss in beagles. The present study was designed to examine the effect of the NSAID, flurbiprofen, on slowing the radiographic loss of alveolar bone in the human. Fifty-six individuals with radiographic evidence of alveolar bone loss were recruited for study. Forty-four patients remained in the study for the data analysis of loss of alveolar bone. Following a 6 month baseline pretreatment period to measure the radiographic progression of bone loss, half of the patients were administered flurbiprofen, 50 mg. b.i.d., while half were administered a placebo. All patients received a subgingival scaling and pumice by a hygienist every 6 months. The rate of alveolar bone loss in a 2 year treatment period was compared to the baseline 6 month pretreatment period within and between patient groups. Throughout the study, teeth exhibiting obvious loss of bone were exited from study and treated with conventional mechanical therapy. At the end of the pretreatment period both patient groups had a similar mean rate of alveolar bone loss.(ABSTRACT TRUNCATED AT 250 WORDS)
J Periodontol 1989 Sep
PMID:Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. 267 1

Records of 63 patients diagnosed as having moderate periodontitis who had been treated and maintained by scaling and root planing for 10 years or longer (mean 13.6 years, range 10 to 34 years) in dental school clinics were reviewed for tooth loss. The patients averaged 45 years of age (range 24 to 67 years) at the initial appointment, and 41 were female. Record audit determined type of periodontal treatment, total tooth loss, periodontally related tooth loss, loss of teeth with furcation invasion, plaque scores, and maintenance interval. Results of therapy were evaluated by groups on the basis of number of teeth lost. At the completion of active periodontal therapy 1,607 teeth were present in the patients. During the maintenance period, 115 teeth (7.1%) were lost and of these 88 (5.0%) were lost due to periodontal reasons. Maxillary and mandibular molar teeth, particularly maxillary second molars, were the teeth lost most frequently to periodontal disease. Of the 164 teeth initially indicated as having furcation invasion, 23% were subsequently lost. This retrospective study confirms the low rate of tooth mortality occurring when patients with periodontal disease are treated and kept on a maintenance program. Canines were the teeth least frequently lost.
J Periodontol 1989 Sep
PMID:Tooth loss in patients with moderate periodontitis after treatment and long-term maintenance care. 267 3

In the past, the age of an individual was considered an important factor in the development of periodontal disease and its treatment. Elderly patients were considered to be at higher risk and have a worse prognosis than younger patients who constituted a low risk category for serious periodontal destruction. Through a critical review of the literature it is pointed out that at the moment age as such can no longer be considered a conditioning factor in the evolution of periodontitis and in its treatment. Rather, it is the proneness of individuals to periodontal disease that is of primary importance in determining periodontal damage, in its prognostic evaluation and in its treatment.
Minerva Stomatol 1989 Sep
PMID:[The age factor in periodontics]. 268 88

The levels of IgG antibody to Bacteroides gingivalis were measured in serum and sequential samples of crevicular fluid from healthy and diseased sites in patients with untreated periodontitis using ELISA. All subjects had detectable serum titres but there was a wide variation in titre between subjects. Moderate to strong correlations were found between serum and crevicular fluid levels of IgG. A statistically significant difference was observed between sequential samples of crevicular fluid. There was no difference in the level of specific IgG to B. gingivalis in crevicular fluid between healthy and diseased sites within the same individual.
Oral Microbiol Immunol 1989 Sep
PMID:A comparison of antibody levels to Bacteroides gingivalis in serum and crevicular fluid from patients with untreated periodontitis. 270 Jul 79

This longitudinal study monitored periodontal status in 20 adults and 20 adolescents undergoing fixed orthodontic treatment. Ten adults had generalized periodontitis and received periodontal treatment, including periodontal surgery, before orthodontic treatment. They also received periodontal maintenance at 3-month intervals during orthodontic treatment. The other 10 adults had normal periodontal tissues. Neither these latter adults nor the adolescents received periodontal maintenance during orthodontic treatment. Periodontal status was determined (1) at six standard sites before fixed appliances were placed (baseline), (2) at 1, 3, 6, 9, 12, and 18 months after appliances had been placed, and (3) 1, 3, 6, and 12 months after appliances had been removed. At each of these visits, these sites were assessed for plaque index, gingival index, bleeding tendency, and pocket depth. Loss of attachment between baseline and 3 months after appliances were removed and tooth loss were also determined. Complete data were obtained for 15 adolescents and 14 adults. During orthodontic treatment the adolescent group showed significantly more (p less than 0.05) periodontal inflammation and supragingival plaque than the adults; after appliances were removed, this pattern was no longer statistically significant. For loss of attachment, there were no significant differences among adolescents, adults with normal periodontal tissues, or adults with reduced but healthy periodontal tissues who had undergone treatment for periodontal disease. For tooth loss, three nonstudy site teeth with pockets deeper than 6 mm and/or furcation involvements were lost because of periodontal abscesses in the adult group treated for periodontal disease.
Am J Orthod Dentofacial Orthop 1989 Sep
PMID:Periodontal implications of orthodontic treatment in adults with reduced or normal periodontal tissues versus those of adolescents. 277 62

The purpose of this study was to assess connective tissue and epithelial responses to periodontitis-affected cementum (from exposed roots of human teeth) after surface demineralization with citric acid. Cementum specimens were obtained from root surfaces covered by calculus. Each rectangular specimen had a face of cementum and an opposite surface composed of pulpal dentin. One half of the specimens were treated with citric acid (experimental group), while the remainder served as untreated control specimens. Specimens were implanted vertically into incisional wounds on the dorsal surface of rats with one end of the implant protruding through the skin. 4 specimens in each group were available for examination 1, 3, 5, and 10 days after implantation. Histologic and histometric analyses of the implants included counts of adhering cells, evaluation of attached connective tissue fiber density and diameter, and assessment of epithelial migration. At 1 day, a distinct zone of surface demineralization was not present on the surface of the cementum in the experimental group, although such a zone was present on the dentin surfaces of the same specimens. Histometric comparisons between experimental and control groups at 1 day showed no differences in cell attachment or length of cementum surface within connective tissue. By 10 days, there was a trend for greater cell attachment to demineralized cementum, but the differences were not statistically significant. Although connective tissue fiber attachment has been shown to occur to demineralized dentin and to normal cementum in this model system, fiber attachment did not occur to the cementum in the present study.(ABSTRACT TRUNCATED AT 250 WORDS)
J Clin Periodontol 1989 Sep
PMID:Cell and fiber responses to cementum from periodontitis-affected root surfaces after citric acid treatment. 277 82

Eosinophilic granuloma is the localized and mildest form of histiocytosis X. It is a destructive osseous lesion characterized by large numbers of eosinophils and histiocytes. The etiology of the disease is unknown. Frequently the jaws, including the periodontium, are involved and the disease stimulates severe localized periodontitis. A case of eosinophilic granuloma of the jawbone is presented. The pertinent clinical features are emphasized and possible problems in the interpretation of clinical periodontal features are discussed.
J Clin Periodontol 1989 Sep
PMID:Diagnostic problems of periodontitis-like lesions caused by eosinophilic granuloma. 277 84


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