Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bone formation is the important factor which contributes to the successful periodontal tissue regeneration in periodontitis and osseointegration of implant placement. To achieve the sufficient bone volume in the process of dental treatment, several growth factors and hormones which enhance bone formation have been evaluated in clinical and preclinical studies. BMP2 and BMP7 have recently been approved for sinus augmentation by FDA. A phase2a randomized controlled clinical studies were conducted to evaluate the potential of GDF5 to stimulate periodontal tissue regeneration and GDF5 significantly stimulated alveolar bone regeneration compared to control. Moreover, increased alveolar bone formation was observed by the use of PTH (1-34) Teriparatide in patients of severe periodontitis. PTH and GDF5 are promising agents for future periodontitis treatment.
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PMID:[Clinical and preclinical application of PTH and BMP to dental treatment]. 2692 87

Regenerative therapies of pathogenic tissue defects are gaining increasing importance in periodontology. Among others, the osteogenic effect of BMP-7 seems to play a major role in the development of teeth and alveolar bone. Human periodontal ligament stem cells (hPDLSC), as well as human mesenchymal stem cells (hMSC), show the ability to differentiate into various types of tissues. Regarding prostaglandin E2, many studies have confirmed that it is involved in the inflammation associated to periodontitis stimulating osteoclasts, which ultimately leads to resorption of tooth supporting bone. Herein, we aimed to investigate how PGE2 influences regenerative processes. The influence of PGE2 and BMP-7 on the osteogenic differentiation of hMSC and hPDLSC was determined in a 3D cell culture model using qRT-PCR, immunocytochemistry and REM. BMP-7 enhanced the expression of osteogenic markers in hMSC and lowered it in hPDLSC-TERT. BMP-7 had a lower osteogenic effect on hPDLSC-hTERT than on hMSC, while PGE2 decreases the osteogenic differentiation in both cell types, thus, inhibiting anabolic processes. Both cell types presented good proliferation and adhesion onto the scaffolds. The well-developed structural morphology and the support of osteogenic differentiation suggest that the scaffolds are potential candidate materials for bone regeneration. The positivity for Cap in hPDLSC and more in hMSC immunostaining samples indicates the initiation of neocementogenesis as part of periodontal regeneration. In conclusion, BMP7, in particular combined with MSC, seems to have a favourable application also in periodontal regeneration. Our results show that inflammation plays an important role in periodontal regeneration. PGE2 is a key mediator, which stimulates bone resorption also via a mechanism involving the inhibition of osteogenic differentiation of MSC as well as PDLSC. Therefore, regenerative approaches should always be conducted in combination with anti-inflammatory measures oriented to control inflammation.
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PMID:Differentiation of hMSC and hPDLSC induced by PGE2 or BMP-7 in 3D models. 2873 26