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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of oral bacteria in the etiology of ankylosing spondylitis (AS) is examined in this review. Periodontitis is related to AS to a significant degree, and periodontitis is significantly more prevalent in patients with AS. Anti-Pophyromonas gingivalis and anti-Prevotella intermedia antibodies titers are higher in AS patients than in healthy subjects. Eight randomized controlled trials that used sulfasalazine were reviewed. Moxifloxacin and rifamycin are significantly effective in the treatment of AS. Periodontal pathogens are likely to be responsible for the development of AS in genetically susceptible individuals. These results will guide more comprehensive and efficacious treatment strategies for AS.
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PMID:Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis. 2600 54

Ankylosing spondylitis (AS) is associated with periodontitis. Anti-Porphyromonas gingivalis and anti-Prevotella intermedia antibody titers were higher in patients with spondyloarthritis than in healthy people. Sulfasalazine is an effective antibiotic treatment for AS. Moxifloxacin and rifamycin were also found to be significantly effective. The etiology hypothesis suggests that oral anaerobic bacteria such as Porphyromonas spp and Prevotella spp contribute to the disease. These bacteria have been identified in AS, and we will discuss their pathogenic properties with respect to our knowledge of the disease. Periodontal pathogens are likely to be responsible for the development of AS in genetically susceptible individuals. This finding should guide the development of more comprehensive and efficacious treatment strategies for AS.
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PMID:Oral Anaerobic Bacteria in the Etiology of Ankylosing Spondylitis. 2863 41

Periodontitis is one of the most widespread oral diseases. Medicated in-situ gels of Moxifloxacin Hydrochloride for extended period of retention in infected cavity were prepared for improved local action for the treatment of periodontitis. Medicated formulations were prepared using temperature sensitive (poloxamer 407), ion sensitive (gellan gum) and pH sensitive (carbopol 934P) polymers. 32 Full Factorial Design has been applied and prepared batches were characterized by FTIR, pH, syringeability, drug content, clarity, gelation temperature, gelling time, in-vitro gelling capacity, in-vitro diffusion study. Gelation temperature, (in-vitro) gelling time and the nature of gel formed in simulated saliva showed polymeric concentration dependency. Diffusion study of in-situ gel had been performed which showed augmented arrival of medication from 7-12 hours and the discharge was dependent on polymer utilized. The best fitted model was zero order kinetics which indicated that the formulation gave controlled delivery. All preparations were non-Newtonian and display pseudoplastic conduct. Invitro Antimicrobial study was carried out by utilizing E. coli and S. aureus. Optimized formulation containing 19.072 %w/v poloxamer 407 and 0.245 %w/v gellan gum exhibited desired characteristics for developing periodontal drug delivery systems.
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PMID:Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activity. 3108 Jul 18