Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study aimed at evaluating the transcriptional profile of apoptosis-related genes after
in vitro
stimulation of peripheral blood mononuclear cells (PBMCs) derived from individuals with
periodontitis
(P) and healthy nonperiodontitis (NP) control subjects with
P. gingivalis
HmuY protein. PBMCs from the P and NP groups were stimulated with HmuY
P. gingivalis
protein, and the expression of genes related to apoptosis was assessed by custom real-time polymerase chain reaction array (Custom RT
2
PCR Array). Compared with the NP group, the P group showed low relative levels of apoptosis-related gene expression, downregulated for FAS, FAS ligand,
TNFSF10
(TRAIL), BAK1, CASP9, and APAF1 after
P. gingivalis
HmuY protein stimulation. Furthermore, the P group exhibited low levels of relative gene expression, downregulated for CASP7 when the cells were not stimulated. Our data suggest that
P. gingivalis
HmuY protein might participate differently in the modulation of the intrinsic and extrinsic apoptosis pathways.
...
PMID:Apoptosis Transcriptional Profile Induced by
Porphyromonas gingivalis
HmuY. 3101 Dec 84
