Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An automated enzyme immunoassay (EIA) to measure prostaglandin E2 (PGE2) in gingival crevicular fluid (GCF) of humans and dogs was developed as an indicator of periodontal disease. GCF is noninvasively collected on Periopaper strips and the PGE2 is extracted by a simple method. Samples containing 10-500 pg/ml PGE2 can be measured. A commercially available kit is used to perform the competitive EIA in microtiter plates. In the EIA, rabbit anti-PGE2 antisera binds to either the PGE2 in the sample or to the acetylcholinesterase-linked PGE2. The assay is automated using the Biomek 1000 workstation, resulting in day-to-day variability of less than 5% CV. Dog models of chronic and ligature-induced periodontitis were used to demonstrate that increased GCF PGE2, as measured by our assay, correlates with increased pocket depth and gingival bleeding scores.
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PMID:Automated enzyme immunoassay to measure prostaglandin E2 in gingival crevicular fluid. 153 3

The liver is an important organ closely associated with lipid and glucose metabolism. This study was performed to clarify the relationship between periodontitis and hepatic condition in apparently healthy Japanese women. A cross-sectional study was performed on 172 apparently healthy, dentulous Japanese women (20-59 years old) who attended a health promotion program at Fukuoka Health Promotion Center. After multivariate adjustment for age, smoking history and oral hygiene, which were known risk factors for periodontitis, the incidence of periodontitis (deepest probing depth > or =4 mm) in females was significantly increased with elevated serum levels of aspartate aminotransferase (AST, p < 0.01), alanine aminotransferase (ALT, p < 0.01) and cholinesterase (p < 0.001), and an AST-to-ALT ratio of less than one (p = 0.02). Further adjustment for either body mass index (BMI) or percent body fat did not attenuate these relationships. These results suggest that hepatic steatosis is associated with periodontitis in Japanese women.
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PMID:Relationship between periodontitis and hepatic condition in Japanese women. 1686 98