Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This double-blind cross-over study was undertaken to assess the effect of systemically administered metronidazole when used as an adjunct to periodontal surgery for the treatment of moderate and advanced periodontitis. The effect of metronidazole was compared with that of placebo in patients undergoing modified Widman flap procedures in two areas of the same jaw which could be matched for type of tooth and severity of the periodontal disease. Clinical and microbiological parameters were examined prior to surgery and then 7 days, 1 month, and 3 to 6 months, postoperatively. The clinical parameters recorded were pocket depth (PD), Sulcus Bleeding Index (SBI), probing attachment level (PAL), and patients' preference and pain score. Subgingival plaque samples were studied with dark-field microscopy for differential bacterial count. Pocket depths and SBIs were reduced significantly at all stages, in both groups. Probing attachment levels increased at 7 days, to significant levels only in the metronidazole group, subsequently PALs decreased in both groups with no significant differences between the groups. Although the differential bacterial count altered markedly in both groups at all times, only the straight rod count at 1 month was significantly (P less than 0.05) lower in the metronidazole group. Metronidazole with surgery did not exert a significantly greater beneficial effect than placebo with surgery.
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PMID:The value of systemically administered metronidazole in the modified Widman flap procedure. 347 Apr 98

Seventy-four patients with acute pulpitis, apical periodontitis, marginal periodontitis, or pulpoperiodontitis were examined. A series of symptoms and signs was registered. Diagnostic specificities and sensitivities were calculated, and thirteen variables were subjected to discriminant analysis and log-linear multiway contingency table analysis. Pulpoperiodonitis was found inseparable from pulpitis on the basis of the registered symptoms and signs. Several symptoms and signs previously believed to have differential diagnostic power were found insignificant. The following combination of symptoms and signs yielded a correct diagnosis in 82.1% of the cases: constant pain, tenderness to temperature changes, "the tooth feels extruded," impaired mouth opening, tenderness to palpation in apical area, and mobility.
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PMID:A differential diagnostic approach to the symptomatology of acute dental pain. 385 23

From September 1981 to February 1982, an epidemiologic study was carried out on the incidence of pain conditions among patients between 18 and 70 yr of age in 30 dental practices in Ribe County, Denmark. A total of 35 464 patients consulted the 50 participating dentists during the study period. 823 patients consulted the dentist due to pain. The most frequent cause of pain was caries sequelae (pulpitis (35%) and acute apical periodontitis (31%)). There was a significant difference in the distribution of the diagnoses between patients with regular and non-regular dental care. Although the data in the present study may not be representative for the entire Danish population, it seems reasonable to assume that in Denmark there are at least 70 000 annual consultations to a dentist due to pain. Furthermore, a minimum of 4000 patients can be expected to be absent from work annually, due to illness caused by dental pain.
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PMID:Incidence of pain conditions in dental practice in a Danish county. 386 9

The efficacy of oral fentiazac (100 mg QID) was compared with that of paracetamol (500 mg QID) in a single-blind trial in 30 patients suffering from post-endodontic periodontitis secondary to infiltrative or abscessed pulpitis. Patients were allocated at random to two treatment groups and treated for four days. Over each of the four days, patients scored the severity of spontaneous pain and induced pain. The same symptoms were assessed by the investigator at 0, 48, and 96 hours. Special attention was paid to the occurrence of adverse reactions. A statistically significant difference favoring fentiazac was seen in the patients' assessments of induced pain (while eating) but not in the investigator's assessment of induced pain (percussion). There was no significant difference in the analgesic effects of fentiazac and paracetamol with respect to spontaneous pain scored by patients or the investigator. No side effects were seen. Fentiazac was shown to be an effective analgesic for use in this painful inflammatory condition.
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PMID:Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodontic periodontitis. 388 39

A double-blind study was made of the activity and tolerance of 400 mg Floctaphenine versus 400 mg Acetylsalicylic Acid (ASA) on ordinary random administration. 48 patients received Floctaphenine and 50 ASA. Menstruating women were included, but not children aged less than 12 yr. Periodontitis, pulpitis, abscesses, extractions and dysodontiasis were the most frequently represented sources of pain. Subjects completing the study were divided into groups: those already treated with other analgesics in the previous 24 hr, those with uninterrupted pain, those with attacks of pain, those for whom one administration was sufficient, menstruating women. Account was also taken of the effect of treatment before or after meals, and the influence of a simultaneously administered antibiotic (the same one in each case). Statistical assessment showed that both drugs were analgesic, but that Floctaphenine was significantly (P < 0.01) better than ASA. The same was true with regard to latency time, duration of the effect, clinical assessment, need for support from other analgesics. The antibiotic appeared to have no appreciable influence of the activity of the two drugs, nor did the time of administration (before or after meals). Much the same picture was apparent in each group. Menstrual status was devoid of influence, though it cannot be stated with equal certainty that whether secondary effects were more frequent. Floctaphenine was very well tolerated. There were 4 somewhat doubtful cases of somnolence (8.33%). It was not certain, in fact, whether this was not an outcome of the relief from pain. ASA was accompanied by stomach pain in 9 cases (18%). This was much more common when it was taken on an empty stomach.
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PMID:[Use of floctafenine in toothaches in adults and children (a controlled study). II]. 610 35

The analgesic activity and tolerance of a new non-narcotic synthetic analgesic derive from quinoline has been experimented in a double blind study. Phloctaphenin (200 mg) was compared with 200 mg of Acetylsalicylic acid (ASA). Administration of the drug was randomized: 41 patients received Phloctaphenin and 37 ASA. In addition to normal patients, the study also included menstruating women and, after paediatric check-up, children (i.e. under-12's). The conditions treated included periodontitis, pulpitis, abscesses, caries (with extraction), dysodontiasis and traumas. Patients were subdivided into groups (already treated with analgesics in the previous 24 h, not treated in the previous 24 h, affected by continuous pain, affected by fits of pain, subjects in whom a single drug administration was sufficient, patients in their menstrual period). Account was also taken of the outcome of treatment in relation to meals and of the influence of the association of an antibiotic (always the same). The study showed that both drugs possess analgesic activity but that of Phloctaphenin is statistically superior (almost always highly significant, i.e. P < 0.01) compared to ASA. The same applies to latency and the duration of the effect, the clinical judgment ad the need to administered other drugs. Association with the antibiotic has no influence whatever as might have been presumed considering the period of administration and the times of assessing the pain killing action of the two drugs. Administration before or after meals was irrelevant for both drugs. Statistical study of individual groups confirmed these results. From the viewpoint of side-effects, Phloctaphenin is better tolerated: with this new analgesic, in effect, only 2 debatable cases (4.87%) of side-effects (somnolence) were observed while 6 of the patients treated with ASA (16.20%) presented side-effects: 3 cases of gastric pyrosis (8.10%) before meals and 3 cases (8.10%) of hyperhydrosis after meals.
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PMID:[Use of floctafenine for dental pain of adults and children; a controlled study. I]. 610 34

One hundred out-patients with inflammatory process of dental tissues due to tooth extraction, root abscess alveolitis and periodontitis, were randomly assigned, according to a double-blind design, to one of two treatment groups with nimesulide (200 mg/day) or oxyphenbutazone (400 mg/day). By means of a self-rating record, each patient rated his pain, difficulty of chewing, redness and swelling before starting, during and at the end of treatment. Nimesulide and oxyphenbutazone were both well tolerated and effective, but the improvements during the first and the second day of treatment were of greater magnitude in the nimesulide-treated patients. Nimesulide, being well tolerated, rapid acting and effective, could be considered as a drug of choice for the treatment of inflammatory process of dental tissues.
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PMID:Nimesulide in the short-term treatment of inflammatory process of dental tissues: a double-blind controlled trial against oxyphenbutazone. 634 46

A method for the detection of prostaglandin E (PGE) in crevicular fluid has been developed which provides a sensitive, noninvasive technique for measurement of local concentrations of this mediator of inflammation. Assay sensitivity sufficient for the detection of 4 picograms of PGE2 was achieved by utilizing a high-affinity anti-PGE2 antibody, a solid-state second antibody and low isotope concentrations. The method permits detection of concentrations equivalent to 10(-8) M PGE2 in 1 microliter of crevicular fluid. Crevicular fluid PGE (CFPGE) concentrations were determined in samples from 12 patients with periodontal disease. Patients with periodontitis had significantly higher mean CFPGE concentrations than patients with gingivitis (179.5 +/- 51.4 pg/microliter vs 32.1 +/- 15.5 pg/microliter, mean +/- SEM). Periodontitis sites were selected on the basis of clinical and radiographic evidence of periodontal destruction. Some sites displayed low CFPGE levels, while others had CFPGE concentrations which were elevated tenfold, suggesting the presence of both inactive and active periodontal lesions. CFPGE levels greater than 100 pg/microliter were positively associated with gingival erythema and pain on probing.
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PMID:Measurement of prostaglandin E in crevicular fluid. 703 2

The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 days. Vibration at 100 Hz was applied to various points in the facial region or the skull. All the patients except three experienced an effective reduction of the intensity of the pain. In the patients who experienced pain reduction there was usually a best point at which vibration had a greater pain alleviating effect than at other points. At some points the stimulation added to the pain. In 16 patients the stimulation caused a reduction in pain intensity of 75--100%; out of these 12 patients reported a complete relief of pain.
Pain 1981 Feb
PMID:Vibratory stimulation for the relief of pain of dental origin. 723 10

Excessive release of kinin (BK) in the synovial fluid can produce oedema, pain and loss of functions due to activation of B1 and B2 kinin receptors. Activation of the kinin forming system could be mediated via injury, trauma, coagulation pathways (Hageman factor and thrombin) and immune complexes. The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue. These mediators are capable of inducing bone and cartilage damage, hypertrophic synovitis, vessel proliferation, inflammatory cell migration and, possibly, angiogenesis in pannus formation. These pathological changes, however, are not yet defined in the human model of chronic inflammation. The role of kinins and their interacting inflammatory mediators would soon start to clarify the detailed questions they revealed in clinical and experimental models of chronic inflammatory diseases. Several B1 and B2 receptor antagonists are being synthesized in an attempt to study the molecular functions of kinins in inflammatory processes, such as rheumatoid arthritis, periodontitis, inflammatory diseases of the gut and osteomyelitis. Future development of specific potent and stable B1 and B2 receptor antagonists or combined B1 and B2 antagonists with y-IFN might serve as a pharmacological basis for more effective treatment of joint inflammatory and related diseases.
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PMID:Pathogenic responses of bradykinin system in chronic inflammatory rheumatoid disease. 770 72


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