Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Type 2 diabetic mellitus is manifested by metabolic impairments with high prevalence worldwide, of which
periodontitis
represents a typical oral complication (also called diabetic
periodontitis
). Oral epithelia bear the brunt of periodontal damage from microscopic intruders; thus the defense function of epithelial cells is of vital significance. We have previously proved that 25-hydroxyvitamin D
3
(25-
OHD
3
) altered the expression of cathelicidin antimicrobial peptide in oral epithelial cells in vitro. Herein, we discovered that 25-
OHD
3
intraperitoneal injection attenuated periodontal inflammation by promoting cathelicidin production in gingival epithelia and reducing fasting glucose of diabetic mice. Dotblotting of serum showed cathelicidin secretion was consistent with 25-
OHD
3
treatment. Immunochemistry exhibited enhanced expression of cathelicidin and vitamin D receptors along with reduced expression of TLR4 in diabetic mice. Stereomicroscope showed less alveolar bone loss when injected with 25-
OHD
3
.These results showed 25-
OHD
3
can promote cathelicidin and ameliorate the severity of diabetic
periodontitis
. Our study complemented the mechanism of cathelicidin and extended knowledge of 25-
OHD
3
's role in diabetic
periodontitis
.
...
PMID:25-Hydroxyvitamin D
3
Alleviates Experimental Periodontitis via Promoting Expression of Cathelicidin in Mice with Type 2 Diabetic Mellitus. 3038 19
