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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leukocyte adhesion deficiency (LAD) type II is the second human disorder identified which involves the adhesion cascade. While in LAD I the integrin family is defective, in LAD II the selectin system is involved. The syndrome has been described in only five patients and is transmitted as an autosomal recessive trait. The infectious episodes and the severity are much milder than those observed in LAD I, and the only persistent clinical symptom is chronic severe periodontitis. Delay separation of the umbilical cord, which is a hallmark for LAD I, was not observed in any of the LAD II patients. The exact defect in the system is absence of the SLeX, which is an important ligand for the selectin on the leukocyte lead ing to a profound defect in leukocyte rolling, the first step in the adhesion cascade. This causes a marked decrease in chemotaxis accompanied by pronounced neutrophilia. Apart from the leukocyte defect, these patients suffer from severe growth and mental retardation and exhibit the rare Bombay blood group type. The primary defect in the syndrome is in fucose metabolism, with the absence of all fucosylated glycans on cell surface membranes. Recently, it is was found that the defect is in a specific transporter of GDP fucose into the Golgi apparatus, and thus no fucosylation process takes place, and no surface expression can be detected. The exact genetic defect in the transporter is still unknown. Four of the patients were of Arabic origin while the fifth was of Turkish origin. It seems that the primary defect is somewhat different and, therefore, fucose administration was effective in the Turkish child, but did not show any beneficial results in the patients of Arabic origin.
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PMID:Leukocyte adhesion deficiency II-from A to almost Z. 1121 99

Actinobacillus actinomycetemcomitans is a Gram-negative coccobacillus that can cause various forms of severe periodontitis and other nonoral infections in human patients. The serotype a-specific polysaccharide antigen of A. actinomycetemcomitans contains solely 6-deoxy-D-talose and its O-2 acetylated modification. This polysaccharide is synthesized from the donor GDP-6-deoxy-D-talose with the relevant talosylation enzyme(s). In the synthesis of GDP-6- deoxy-D-talose, GDP-D-mannose is first converted by GDP-mannose-4,6-dehydratase (GMD) to GDP-4-keto-6-deoxy-D-mannose and then reduced to GDP-6-deoxy-D-talose by GDP-6-deoxy-D-talose synthetase (GTS). In this study, we cloned and overexpressed in Escherichia coli the A. actinomycetemcomitans GTS enzyme responsible for the synthesis of GDP-6-deoxy-D-talose. The recombinant A. actinomycetemcomitans GTS enzyme expressed in E. coli converted the GDP-4-keto-6-deoxy-intermediate to a novel GDP-deoxyhexose. The synthesized GDP-deoxyhexose was shown to be GDP-6-deoxy-D-talose by HPLC, MALDI-TOF MS, and NMR spectroscopy. The functional expression of gts provides another enzymatically defined pathway for the synthesis of GDP-deoxyhexoses, which can be used as donors for the corresponding glycosyltransferases.
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PMID:Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans. 1262 85

The aim of the present review is to evaluate the periodontal conditions and treatment needs in Central and Eastern Europe and to compare these data to the epidemiological data from the industrialised and developing countries. The recent prevalence and severity data provided by national surveys based on the CPITN methods are summarised. The periodontal conditions in the age groups 15-19 and 35-44 are discussed in detail. The CPITN data show no major differences in the extent and severity of destructive periodontal disease in different countries. In the age group 15-19 just a few European surveys reported 'score 4 sextant' and the prevalence of 'score 3' sextants was also below 10% in each survey. However calculus formation and bleeding on probing were very frequent findings both in Western and Eastern Europe. In the age group 35-44 the average prevalence of 'score 4 sextant' in Western and Eastern Europe were comparable while the proportion of periodontally absolutely healthy individuals was lower in Eastern Europe than in the Western part of the Continent. Five to 20% of the populations are affected by destructive periodontitis at the age of 40. This indicates the magnitude of the disease as a public health problem both in the industrialised West and the Eastern European countries. The same 10-15% prevalence rate of destructive periodontitis imposes a great challenge to the health authorities of these post-communist countries amid social and economic transition, because the nationwide preventive and basic periodontal therapeutic measures should be managed and financed from a substantially lower GDP than in the industrialised West.
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PMID:Periodontal treatment needs in Central and Eastern Europe. 1266 70

The aim of the present review is to evaluate the periodontal conditions and treatment needs in Central and Eastern European countries joining the European Union and to compare these data to the epidemiological data from the industrialised and developing countries. The recent prevalence and severity data provided by national surveys based on the CPITN methods are summarised. The periodontal conditions in the age groups 15-19 and 35-44 are discussed in details. The CPITN data show no major differences in the extent and severity of destructive periodontal disease in the different countries. In the age group 15-19 just a few European surveys reported "score 4 sextant" and the prevalence of "score 3 sextants" was also below 10% in each survey. However calculus formation and bleeding on probing were very frequent findings both in Western and Eastern Europe. In the age group 35-44 the average prevalence of "score 4 sextant" in Western and Eastern Europe were comparable while the proportion of periodontally absolutely healthy individuals was lower in Eastern Europe than in the Western part of the Continent. Five to twenty per cent of the populations are affected by destructive periodontitis at the age of 40. This indicates the magnitude of the disease as a public health problem both in the industrialised West and the Eastern European countries. The some 10-15% prevalence rate of destructive periodontitis imposes a great challenge to the health authorities of these post-communist countries amid social and economic transition, because the nation-wide preventive and basic periodontal therapeutic measures should be managed and financed from a substantially lower GDP than in the industrialised West.
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PMID:[Periodontal treatment needs in Central and Eastern Europe]. 1563 Oct 46

Aims To assess the management of chronic periodontitis (CP) in general dental practices based in the West Midlands against the British Society of Periodontology (BSP) guidelines and determine whether this varies between NHS, private and mixed sector practices. To examine general dental practitioners' (GDPs') attitudes towards the management of periodontitis, the implementation of the BSP guidelines and explore their suggestions for improved management of the disease.Materials and methods A semi-structured telephone interview was conducted with eight dentists to construct an online questionnaire. Using the NHS Choices database, the practice managers of 30 dental practices were contacted and asked to distribute the online questionnaire to all GDPs within their practice.Results One hundred and three GDPs completed the questionnaire; several dentists indicated their management would not align with the BSP recommendations. Dentists do not believe the BSP guidelines are easy to implement in NHS practice.Discussion Areas where dentists are falling short of the BSP guidelines include periodontal charting, indications for root surface debridement (RSD) and antimicrobials. These topics should be highlighted to dentists. Dentists would prefer NHS remuneration to reflect the time and effort spent, better access to secondary care and increased awareness of periodontal diseases among patients.Conclusion This study identifies clear areas where dentists are not following the BSP guidelines and provides insight from a GDP's perspective to improve the management of CP in practice.
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PMID:An explorative study of the current practice and attitude towards the management of chronic periodontitis by general dental practitioners in the West Midlands. 3227 13