Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0031099 (periodontitis)
 12,489 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This work presents the results of a immunohistochemical study, performed in order to identify the cells in human dental pulp which express neural markers. Population of cells expressing neuron-specific enolase, synaptophysin, and chromogranin A, which were stained by paraldehyde-fuchsin, was demonstrated in subodontoblastic layer of the dental pulp. Changes the number, morphological and functional characteristics during development of caries and pulpitis in combination with periodontitis are described.
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PMID:[Identification of the cells expressing neural markers in normal and pathological human dental pulp]. 1772 71

Neuroendocrine cells were identified in human dental pulp by immunohistochemical method using monoclonal antibodies. A population of neuroendocrine cells positively reacting to neuron-specific enolase, synaptophysin, chromogranin A, and stained with paraldehyde-fuchsin, was detected in the subodontoblastic layer of the pulp. Changes in their count, morphology, and function in caries and pulpitis concomitant with periodontitis were proven.
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PMID:Neuroendocrine cells in the dental pulp in health and disease. 1845 32

The relationship between periodontitis and stress-related hormones is poorly understood. In this cross-sectional study we investigated the associations between the stress-related hormone, chromogranin A (CgA) and periodontitis in healthy community-dwelling elderly subjects aged 60 years old and older. A total of 171 subjects (85 males, 86 females; mean age of 68.4 +/- 4.46 (SD) years old) participated, all of whom were living independently. Stimulated whole saliva samples were collected and CgA levels were determined, while a medical questionnaire regarding medical conditions and lifestyle was also administered. Clinical examinations included probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (CAL). When the subjects were divided into two groups based on periodontitis severity, the salivary CgA levels were significantly higher in subjects with severe PD or CAL. Multiple regression analysis showed that higher CgA level was significantly associated with greater numbers of teeth with severe PD or CAL, after adjusting for confounding variables. In this first known report of the association between CgA level and periodontitis, our results suggest a close relationship between the extent and severity of periodontitis and salivary level of CgA in healthy elderly subjects.
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PMID:Association between salivary levels of chromogranin A and periodontitis in older Japanese. 1861 45

The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic about the severity of neurological diseases, such as lateral amyotrophic sclerosis and traumatic brain injuries. The aim of this mini-review is to highlight the role of neuroendocrine molecules as advantageous diagnostic and prognostic markers for both oral diseases and neurodegenerative disorders.
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PMID:From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases. 3126 55