Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and
periodontitis
. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate-gene association study, we identify an association of a genetic susceptibility locus shared by both diseases. We confirm the known association of two neighboring linkage disequilibrium regions on human chromosome 9p21.3 with CHD and show the additional strong association of these loci with the risk of aggressive
periodontitis
. For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33-2.94; P = 6.9 x 10(-4)) for generalized aggressive
periodontitis
, and 1.72 (1.06-2.76; P = 2.6 x 10(-2)) for localized aggressive
periodontitis
. The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of
CDKN2A
/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and
periodontitis
risk haplotypes. Our study demonstrates that CHD and
periodontitis
are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and
periodontitis
promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases.
...
PMID:Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. 1921 2
Epidemiological studies have indicated a relationship between coronary heart disease (CHD) and
periodontitis
. Recently, CDKN2BAS was reported as a shared genetic risk factor of CHD and aggressive
periodontitis
(AgP), but the causative variant has remained unknown. To identify and validate risk variants in different European populations, we first explored 150 kb of the genetic region of CDKN2BAS including the adjacent genes
CDKN2A
and CDKN2B, covering 51 tagging single nucleotide polymorphisms (tagSNPs) in AgP and chronic
periodontitis
(CP) in individuals of Dutch origin (n=313). In a second step, we tested the significant SNP associations in an independent AgP and CP population of German origin (n=1264). For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004). We further showed in vivo gene expression of CDKN2BAS,
CDKN2A
, CDKN2B, and CDK4 in healthy and inflamed gingival epithelium (GE) and connective tissue (CT), and detected a significantly higher expression of CDKN2BAS in healthy CT compared to GE (p=0.004). After 24 h of stimulation with Porphyromonas gingivalis in Streptococcus gordonii pre-treated gingival fibroblast (HGF) and cultured gingival epithelial cells (GECs), we observed a 25-fold and fourfold increase of CDKN2BAS gene expression in HGFs (p=0.003) and GECs (p=0.004), respectively. Considering the global importance of CDKN2BAS in the disease risk of CHD, this observation supports the theory of inflammatory components in the disease physiology of CHD.
...
PMID:CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection. 2097 19
Four new triterpenoid bidesmosidic saponins (
1
-
4
) and a sesquiterpenoid glucoside (
5
), together with nine known phenolic compounds (
6
-
14
), were isolated from the fruits of
Elaeagnus umbellata
. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound
6
decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H
2
O
2
decreasing the expression of p21 and
CDKN2A
(p16
INK4A
). Compound
6
decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in
periodontitis
lesions.
...
PMID:Antioxidant Activity of Compounds Isolated from
Elaeagnus umbellata
Promotes Human Gingival Fibroblast Well-Being. 3203 8
