Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0031099 (
periodontitis
)
12,489
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like
periodontitis
. Current evidence shows that these inflammatory mediators have a definitive role in the pathogenesis of various systemic diseases with an inflammatory component.
Interleukin-21
(
IL-21
) has been associated with systemic diseases like rheumatoid arthritis and Crohn's disease that follow a chronic inflammatory cascade. Similarly recent studies have associated
Interleukin-21
levels with
periodontitis
. This systematic review was aimed to assess the levels of
IL-21
in subjects with
periodontitis
. Methods. A complete literature search was done in PubMed, Medline, Science Direct, and Cochrane databases and Google Scholar based on the inclusion/exclusion criteria. Six relevant articles were procured. Full text was read individually by two reviewers and data extraction was done based on STROBE statement. Results. After data extraction five observational and one interventional study were obtained. All the studies showed an increased expression of
IL-21
in
periodontitis
and the interventional study showed reduction in
IL-21
levels after nonsurgical periodontal therapy (NSP). Conclusion.
Interleukin-21
levels are higher in
periodontitis
than controls. With this limited evidence further longitudinal studies are required to consider this as a definitive inflammatory marker.
...
PMID:The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review. 2699 77
