Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030794 (
pelvic pain
)
4,056
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Endometriosis, defined as the presence of endometrial cells outside of the uterine cavity, is a major cause of infertility and
pelvic pain
, afflicting more than 10% of reproductive age women. Endometriosis is a chronic inflammatory disease and lipopolysaccharide promotes the proliferation and invasion of endometriotic stromal cells.
Cysteine-rich secretory protein LCCL domain-containing 2
(
CRISPLD2
) has high affinity for lipopolysaccharide and plays a critical role in defense against endotoxin shock. However, the function of
CRISPLD2
has not been studied in endometriosis and uterine biology. Herein, we examined the expression of
CRISPLD2
in endometrium from patients with and without endometriosis using immunohistochemistry. The expression of
CRISPLD2
was higher in the secretory phase in human menstrual cycle compared to proliferative phase. The expression of
CRISPLD2
was significantly decreased in the endometrium of women with endometriosis in the early secretory phase compared to women without endometriosis. The increase of
CRISPLD2
expression at the early secretory and dysregulation of its expression in endometriosis suggest progesterone (P4) regulation of
CRISPLD2
. To investigate whether
CRISPLD2
is regulated by P4, we examined the expression of the
CRISPLD2
in the uteri of wild-type and progesterone receptor knock out (PRKO) mice. The expression of
CRISPLD2
was significantly increased after P4 treatment in the wild-type mice. However,
CRISPLD2
expression was significantly decreased in the (PRKO) mice treated with P4. During early pregnancy, the expression of
CRISPLD2
was increased in decidua of implantation and post-implantation stages.
CRISPLD2
levels were also increased in cultured human endometrial stromal cells during in vitro decidualization. These results suggest that the
CRISPLD2
is a target of the progesterone receptor and may play an important role in pathogenesis of endometriosis.
...
PMID:CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. 2495 63
