Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030794 (pelvic pain)
 4,056 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to evaluate the contribution of tubal spasm to pelvic pain following laparoscopic sterilisation, we have studied the effect of glycopyrrolate, an anticholinergic agent with antispasmodic properties, on 60 ASA 1 and 2 patients presenting as day-cases for laparoscopic sterilisation using Filshie clips. In a randomised, double-blind, controlled trial, patients received either glycopyrrolate 0.3 mg or saline intravenously prior to induction of anaesthesia. Compared with the control group, patients receiving glycopyrrolate had significantly reduced immediate postoperative pain scores (p < 0.02) and required significantly less postoperative morphine (p < 0.01). Nausea, vomiting and anti-emetic requirements were also reduced though not significantly. We conclude that glycopyrrolate 0.3 mg at induction of anaesthesia is an effective method of improving the quality of recovery after day-case laparoscopic sterilisation using clips.
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PMID:The effect of glycopyrrolate on postoperative pain and analgesic requirements following laparoscopic sterilisation. 903 63

The physiological basis for the use of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of acute pelvic pain in women was examined in terms of: (i) the electrophysiological responses of epithelial cells in the human Fallopian tube; and (ii) the longitudinal and circular contractions of the myosalpinx. Epithelial cells were grown as a polarized layer in primary culture, and transepithelial potential difference (p.d.) and short-circuit current (I(scc)) were recorded using a modified Ussing chamber. The inflammatory mediators histamine (0.1-100.0 micromol l(-1)) and platelet activating factor (PAF) (1.9-1900.0 nmol l(-1)) increased p.d. and I(scc) in a dose-dependent manner. Pre-incubation with the NSAID diclofenac sodium (100 micromol l(-1)) inhibited the histamine- and PAF-induced stimulation of p.d. and I(scc). Aspirin (100 micromol l(-1)), ibuprofen (100 micromol l(-1)), indomethacin (100 micromol l(-1)) or naproxen (100 micromol l(-1)) were only partially effective. Histamine (0.1-1000.0 micromol l(-1)) increased the frequency of contractions of longitudinal and circular smooth muscle in segments of Fallopian tube in vitro, in a dose-dependent manner. Pre-incubation with diclofenac significantly reduced the histamine-induced stimulation of tubal smooth muscle contraction at the higher doses of histamine. The other NSAIDs had no effect. These data provide evidence that diclofenac downregulates acute inflammation in the human Fallopian tube and may be of use as an anti-inflammatory agent in the treatment of pelvic inflammatory disease.
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PMID:Effect of inflammatory mediators on the physiology of the human Fallopian tube. 1208 8