Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030794 (
pelvic pain
)
4,056
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of the present study was to examine whether the expression of
focal adhesion kinase
(
FAK
) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of
FAK
was assessed by immunohistochemical, western blot and reverse transcription-quantitative polymerase chain reaction analyses. An elevated expression of
FAK
mRNA and protein was identified in the eutopic endometrium of patients with adenomyosis compared with patients without adenomyosis (P<0.05). In addition, a positive correlation was detected between
FAK
protein expression and dysmenorrhea and
pelvic pain
in females with adenomyosis (P<0.05). The significant increase of
FAK
expression identified in the eutopic endometrium of females with adenomyosis, as well as the association of
FAK
protein expression with dysmenorrhea and
pelvic pain
, suggested that
FAK
may play a role in the pathogenesis of adenomyosis.
...
PMID:Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain. 2664 May 70
