Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030794 (pelvic pain)
 4,056 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Female genital tuberculosis is not uncommon in countries where pulmonary tuberculosis is widespread. Improved diagnostic techniques (e.g., endometrial curettage and biopsy, histologic examination of curettage, hysterosalpingography, bacteriologic examination of menstrual blood, laparoscopy, and ultrasonography) have resulted in increased awareness of genital tuberculosis. Another trend has been heightened awareness of the potential role of female genital tuberculosis in infertility; this infection has been implicated in 5-10% of infertility cases. Genital organs most frequently affected include fallopian tubes (95-100%), endometrium (50-60%), and ovaries (20-30%). In 92% of cases, genital tuberculosis is secondary to a focus in the lungs, lymph nodes, urinary tract, bones, or joints. Given the hormone-dependent nature of female genital tuberculosis, 90% of cases involve women under 40 years of age. The major presenting symptoms are infertility (45-55%), pelvic pain (50%), poor general health (25%), and menstrual disturbances (20%). The differential diagnosis includes chronic pelvic inflammation, mycotic infection, enterobiasis, lipid salpingitis, and carcinoma. Female genital tuberculosis is treated with the same long-term, combined drug therapy used in pulmonary and extrapulmonary tuberculosis. Surgery should be undertaken only after continuous drug treatment of 12-18 months' duration. In women of childbearing age, an attempt can be made to preserve one ovary. Successful pregnancy is unlikely, however, after complete antituberculosis treatment or tuboplastic surgery.
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PMID:Overview of tuberculosis of the female genital tract. 901 82

Menstrual patterns differ even in nongenital tuberculosis. Our objective is to determine whether nongenital tuberculosis makes menstrual dysfunction, before and sustain after treatment. Menstrual patterns were compared in women with pulmonary or extrapulmonary but nongenital tuberculosis with healthy nursing students and also with themselves, before and after treatment in a retrospective cohort study. Subjects were selected by convenient nonrandomized sampling but control groups were selected by random allocation among volunteers of nursing students. Case and control subjects were matched in age group. Menstrual patterns including amount, duration, interval, cessation of period, any menstrual irregularity, and pelvic pain were evaluated. Among 100 cases of proven tuberculosis, 90 patients had pulmonary and 10 cases had extrapulmonary tuberculosis. Secondary amenorrhea (P < or = .001, RR: 22), spotting during menstrual period (P < or = .0001, RR: 4.5), decreasing in amount (P < or = .001, RR: 7.8), shorter duration of menstrual period (P < or = .001, RR: 12), and pelvic pain (P < or = .001, RR: 8.6) were more prevalent and significantly different in the cases compared to control subjects (with CI:95% and P < .001), but excessive or prolong vaginal bleeding was not observed. Menstrual disorders occur even in nongenital tuberculosis, but it is manifested with cessation or decrease in menstrual bleeding flow and period.
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PMID:Menstrual disorders in nongenital tuberculosis. 1709 48